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. 1979 Jun;291:393–412. doi: 10.1113/jphysiol.1979.sp012821

The nature of the atrial receptors responsible for a reflex increase in heart rate in the dog.

C T Kappagoda, R J Linden, N Sivananthan
PMCID: PMC1280909  PMID: 480230

Abstract

1. In dogs anaesthetized with chloralose, small latex balloons were positioned at the left pulmonary vein-atrial junctions so as to stretch this region. By recording action potentials from slips of the cervical vagi it was established that distension of these balloons stimulated receptor endings in the atrial endocardium which discharged into the myelinated branches of the vagi i.e. Paintal type A, type B and Intermediate type receptors. 2. In other dogs, cooling the cervical vagus in steps of 2 degrees C reduced this response in vagal myelinated fibres. With twelve receptors the response to distension was reduced by 30% when the vagus was cooled to 16 degrees C, by 70% when cooled to 12 degrees C and abolished at 8--12 degrees C. 3. In a third group of dogs, distension of balloons at the pulmonary vein-atrial junctions resulted in a reflex increase in heart rate. Cooling the cervical vagi in these dogs in stages to 8 degrees C reduced this increase in heart rate. In nine dogs the response was reduced by 20% when the vagi was cooled to 16 degrees C, by 70% when cooled to 12 degrees C and abolished between 12 and 8 degrees C. 4. In a fourth group of dogs, distension of balloons at the pulmonary vein-atrial junctions was shown also to activate receptor endings in the atria which discharged into non-myelinated branches of the Vagi. In twelve receptors, cooling the cervical vagus in steps of 2 degrees C reduced this evoked increase in activity in non-myelinated fibres. These responses were abolished over a wide range of temperature unlike the responses observed above. 5. It is concluded that the increase in heart rate which follows distension of balloons at the pulmonary vein-atrial junctions is mediated solely by the Paintal-type receptors which discharge into the myelinated fibres in the vagi.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLERIDGE J. C., HEMINGWAY A., HOLMES R. L., LINDEN R. J. The location of atrial receptors in the dog: a physiological and histological study. J Physiol. 1957 Apr 3;136(1):174–197. doi: 10.1113/jphysiol.1957.sp005750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carswell F., Hainsworth R., Ledsome J. R. The effects of distension of the pulmonary vein-atrial junctions upon peripheral vascular resistance. J Physiol. 1970 Mar;207(1):1–14. doi: 10.1113/jphysiol.1970.sp009044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coleridge H. M., Coleridge J. C., Dangel A., Kidd C., Luck J. C., Sleight P. Impulses in slowly conducting vagal fibers from afferent endings in the veins, atria, and arteries of dogs and cats. Circ Res. 1973 Jul;33(1):87–97. doi: 10.1161/01.res.33.1.87. [DOI] [PubMed] [Google Scholar]
  4. DICKINSON C. J. Afferent nerves from the heart region. J Physiol. 1950 Oct 16;111(3-4):399–407. doi: 10.1113/jphysiol.1950.sp004491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Franz D. N., Iggo A. Conduction failure in myelinated and non-myelinated axons at low temperatures. J Physiol. 1968 Dec;199(2):319–345. doi: 10.1113/jphysiol.1968.sp008656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gilmore J. P., Zucker I. H. Discharge of type B atrial receptors during changes in vascular volume and depression of atrial contractility. J Physiol. 1974 Jun;239(2):207–223. doi: 10.1113/jphysiol.1974.sp010564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kappagoda C. T., Linden R. J., Mary D. A. Atrial receptors in the cat. J Physiol. 1976 Nov;262(2):431–446. doi: 10.1113/jphysiol.1976.sp011603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kappagoda C. T., Linden R. J., Mary D. A. Atrial receptors in the dog and rabbit. J Physiol. 1977 Nov;272(3):799–815. doi: 10.1113/jphysiol.1977.sp012074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kappagoda C. T., Linden R. J., Mary D. A. Gradation of the reflex response from atrial receptors. J Physiol. 1975 Oct;251(2):561–567. doi: 10.1113/jphysiol.1975.sp011108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kappagoda C. T., Linden R. J., Saunders D. A. The effect on heart rate of distending the atrial appendages in the dog. J Physiol. 1972 Sep;225(3):705–719. doi: 10.1113/jphysiol.1972.sp009965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kappagoda C. T., Linden R. J., Scott E. M., Snow H. M. Atrial receptors and heart rate: the efferent pathway. J Physiol. 1975 Aug;249(3):581–590. doi: 10.1113/jphysiol.1975.sp011031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kappagoda C. T., Linden R. J., Sivananthan N. The receptors which mediate a reflex increase in heart rate [proceedings]. J Physiol. 1977 Mar;266(1):89P–90P. [PubMed] [Google Scholar]
  13. Kappagoda C. T., Linden R. J., Snow H. M. The effect of stretching the superior vena caval-right atrial junction on right atrial receptors in the dog. J Physiol. 1972 Dec;227(3):875–887. doi: 10.1113/jphysiol.1972.sp010063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kidd C., Ledsome J. R., Linden R. J. The effect of distension of the pulmonary vein-atrial junction on activity of left atrial receptors. J Physiol. 1978 Dec;285:445–453. doi: 10.1113/jphysiol.1978.sp012581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. LEDSOME J. R., LINDEN R. J. A REFLEX INCREASE IN HEART RATE FROM DISTENSION OF THE PULMONARY-VEIN-ATRIAL JUNCTIONS. J Physiol. 1964 Apr;170:456–473. doi: 10.1113/jphysiol.1964.sp007343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Linden R. J. Reflexes from receptors in the heart. Cardiology. 1976;61 Suppl 1:7–30. doi: 10.1159/000169788. [DOI] [PubMed] [Google Scholar]
  17. Malliani A., Recordati G., Schwartz P. J. Nervous activity of afferent cardiac sympathetic fibres with atrial and ventricular endings. J Physiol. 1973 Mar;229(2):457–469. doi: 10.1113/jphysiol.1973.sp010147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. PAINTAL A. S. VAGAL AFFERENT FIBRES. Ergeb Physiol. 1963;52:74–156. [PubMed] [Google Scholar]
  19. Paintal A. S. Re-evaluation of respiratory reflexes. Q J Exp Physiol Cogn Med Sci. 1966 Apr;51(2):151–163. doi: 10.1113/expphysiol.1966.sp001836. [DOI] [PubMed] [Google Scholar]
  20. Purves M. J. The respiratory response of the new-born lamb to inhaled CO-2 with and without accompanying hypoxia. J Physiol. 1966 Jul;185(1):78–94. doi: 10.1113/jphysiol.1966.sp007973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sleight P., Widdicombe J. G. Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle. J Physiol. 1965 Nov;181(2):235–258. doi: 10.1113/jphysiol.1965.sp007758. [DOI] [PMC free article] [PubMed] [Google Scholar]

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