Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1979 Feb;287:455–466. doi: 10.1113/jphysiol.1979.sp012670

Left ventricular inotropic responses to stimulation of carotid body chemoreceptors in anaesthetized dogs.

R Hainsworth, F Karim, O A Sofola
PMCID: PMC1281506  PMID: 430429

Abstract

1. Dogs were anaesthetized with chloralose and artificially ventilated. The regions of both carotid bifurcations were vascularly isolated and perfused at constant pressure with arterial blood or with venous or hypoxic blood. 2. Inotropic responses were assessed by measuring the maximum rate of change of left ventricular pressure (dP/dtmax) with aortic pressure and heart rate held constant. 3. Stimulation of the chemoreceptors with venous blood from the inferior vena cava resulted in a decrease in dP/dtmax from 510 +/- 27 kPa.s-1 to 418 +/- 21 kPa.s-1 (mean +/- S.E.): a change of 17.9 +/- 1.0% 4. In experiments in which the oxygen tension of the blood perfusing the carotid chemoreceptors was decreased in steps between 10 and 3 kPa, by use of an oxygenator, graded responses of dP/dtmax were obtained at each step. 5. The inotropic responses to chemoreceptor stimulation were abolished by raising carotid pressure. 6. The inotropic responses were abolished either by crushing both carotid bodies or both ansae subclaviae, indicating that the reflex originates from the carotid bodies and that the efferent pathway is in the cardiac sympathetic nerves.

Full text

PDF
457

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANICHKOV S. V., MALYGHINA E. I., POSKALENKO A. N., RYZHENKOV V. E. Reflexes from carotid bodies upon the adrenals. Arch Int Pharmacodyn Ther. 1960 Dec 1;129:156–165. [PubMed] [Google Scholar]
  2. Biscoe T. J., Purves M. J., Sampson S. R. The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded in vivo with intact circulation. J Physiol. 1970 May;208(1):121–131. doi: 10.1113/jphysiol.1970.sp009109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DE BURGH DALY M., SCOTT M. J. An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dog. J Physiol. 1962 Aug;162:555–573. doi: 10.1113/jphysiol.1962.sp006950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DE DALY M. B., SCOTT M. J. The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J Physiol. 1958 Nov 10;144(1):148–166. doi: 10.1113/jphysiol.1958.sp006092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DOWNING S. E., REMENSNYDER J. P., MITCHELL J. H. Cardiovascular responses to hypoxic stimulation of the carotid bodies. Circ Res. 1962 Apr;10:676–685. doi: 10.1161/01.res.10.4.676. [DOI] [PubMed] [Google Scholar]
  6. De Geest H., Levy M. N., Zieske H. Carotid chemoreceptor stimulation and ventricular performance. Am J Physiol. 1965 Sep;209(3):564–570. doi: 10.1152/ajplegacy.1965.209.3.564. [DOI] [PubMed] [Google Scholar]
  7. Furnival C. M., Linden R. J., Snow H. M. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure. J Physiol. 1970 Dec;211(2):359–387. doi: 10.1113/jphysiol.1970.sp009283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Furnival C. M., Linden R. J., Snow H. M. The inotropic effect on the heart of stimulating the vagus in the dog, duck and toad. J Physiol. 1973 Apr;230(1):155–170. doi: 10.1113/jphysiol.1973.sp010180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hainsworth R., Karim F. Responses of abdominal vascular capacitance in the anaesthetized dog to changes in carotid sinus pressure. J Physiol. 1976 Nov;262(3):659–677. doi: 10.1113/jphysiol.1976.sp011614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heistad D. D., Abboud F. M., Mark A. L., Schmid P. G. Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest. 1974 May;53(5):1226–1236. doi: 10.1172/JCI107669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KAHLER R. L., GOLDBLATT A., BRAUNWALD E. The effects of acute hypoxia on the systemic venous and arterial systems and on myocardial contractile force. J Clin Invest. 1962 Jul;41:1553–1563. doi: 10.1172/JCI104612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mancia G. Influence of carotid baroreceptors on vascular responses to carotid chemoreceptor stimulation in the dog. Circ Res. 1975 Feb;36(2):270–276. doi: 10.1161/01.res.36.2.270. [DOI] [PubMed] [Google Scholar]
  13. NEAL J. J., Jr, HALPERN W., REEVES T. J. Velocity and acceleration of pressure change in heart and arteries. J Appl Physiol. 1960 Jul;15:747–749. doi: 10.1152/jappl.1960.15.4.747. [DOI] [PubMed] [Google Scholar]
  14. Pace J. B. Influence of carotid chemoreceptor stimulation on ventricular dynamics. Am J Physiol. 1970 Jun;218(6):1687–1696. doi: 10.1152/ajplegacy.1970.218.6.1687. [DOI] [PubMed] [Google Scholar]
  15. Pelletier C. L. Circulatory responses to graded stimulation of the carotid chemoreceptors in the dog. Circ Res. 1972 Sep;31(3):431–443. doi: 10.1161/01.res.31.3.431. [DOI] [PubMed] [Google Scholar]
  16. SALEM H., PENNA M., AVIADO D. M. MECHANISM FOR BRADYCARDIA ARISING FROM STIMULATION OF CAROTID BODIES. Arch Int Pharmacodyn Ther. 1964 Jul 1;150:249–258. [PubMed] [Google Scholar]
  17. SARNOFF S. J., BROCKMAN S. K., GILMORE J. P., LINDEN R. J., MITCHELL J. H. Regulation of ventricular contraction. Influence of cardiac sympathetic and vagal nerve stimulation on atrial and ventricular dynamics. Circ Res. 1960 Sep;8:1108–1122. doi: 10.1161/01.res.8.5.1108. [DOI] [PubMed] [Google Scholar]
  18. Stern S., Rapaport E. Comparison of the reflexes elicited from combined or separate stimulation of the aortic and carotid chemoreceptors on myocardial contractility, cardiac output and systemic resistance. Circ Res. 1967 Feb;20(2):214–227. doi: 10.1161/01.res.20.2.214. [DOI] [PubMed] [Google Scholar]
  19. Trzebski A., Lipski J., Majcherczyk S., Szulczyk P., Chruścielewski L. Central organization and interaction of the carotid baroreceptor and chemoreceptor sympathetic reflex. Brain Res. 1975 Apr 11;87(2-3):227–237. doi: 10.1016/0006-8993(75)90420-5. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES