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. 1978 May;278:435–440. doi: 10.1113/jphysiol.1978.sp012314

Oxygen consumption and neonatal sleep states

J K Stothers 1, Ruth M Warner 1
PMCID: PMC1282359  PMID: 209169

Abstract

1. In thirty full-term infants in the first week of life, nursed in a constant volume, closed-circuit metabolism chamber in a neutral thermal environment (31·5-33·5 °C), measurements were made of oxygen consumption (˙VO2) during periods of rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep.

2. The mean ˙VO2 during REM sleep was 5·97 ml. kg-1. min-1. In NREM sleep the mean ˙VO2 was 5·72 ml. kg-1. min-1. This difference was significant (paired t test P < 0·05).

3. When the direction of sleep state change was taken into account the difference in ˙VO2 between the two states was much less when REM sleep preceded NREM than when the change was in the opposite direction. In nineteen infants in whom the change was from REM to NREM the difference in ˙VO2 (6·18 and 6·03 ml. kg-1. min-1) was not significant (P > 0·05). The mean difference when the sleep state change was from NREM to REM was significant (P < 0·01), the values being 5·54 and 5·81 ml. kg-1. min-1 respectively.

4. In the NREM state, a gradual diminution of ˙VO2 with time was consistently found. This was not the case in REM sleep.

5. In twelve infants studied in a cool environment (29 ± 0·5 °C) ˙VO2 during REM sleep was 7·77, and during NREM sleep it was 6·58 ml. kg-1. min-1, (P < 0·001). Thus even the maximum difference found in a neutral thermal environment of 6·6% was significantly increased to 14·9% (P < 0·01) with mild thermal stress.

6. No consistent changes in ˙VO2 with time were found in either REM or NREM sleep in twelve infants studied in a cool environment, in contrast to the findings in thermal neutrality

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASERINSKY E., KLEITMAN N. Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science. 1953 Sep 4;118(3062):273–274. doi: 10.1126/science.118.3062.273. [DOI] [PubMed] [Google Scholar]
  2. Bolton D. P., Herman S. Ventilation and sleep state in the new-born. J Physiol. 1974 Jul;240(1):67–77. doi: 10.1113/jphysiol.1974.sp010599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brebbia D. R., Altshuler K. Z. Oxygen consumption rate and electroencephalographic stage of sleep. Science. 1965 Dec 17;150(3703):1621–1623. doi: 10.1126/science.150.3703.1621. [DOI] [PubMed] [Google Scholar]
  4. Hey E. N., Katz G. Evaporative water loss in the new-born baby. J Physiol. 1969 Feb;200(3):605–619. doi: 10.1113/jphysiol.1969.sp008711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hey E. N. The relation between environmental temperature and oxygen consumption in the new-born baby. J Physiol. 1969 Feb;200(3):589–603. doi: 10.1113/jphysiol.1969.sp008710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hill J. R., Rahimtulla K. A. Heat balance and the metabolic rate of new-born babies in relation to environmental temperature; and the effect of age and of weight on basal metabolic rate. J Physiol. 1965 Sep;180(2):239–265. doi: 10.1113/jphysiol.1965.sp007701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KLEITMAN N., ENGELMANN T. G. Sleep characteristics of infants. J Appl Physiol. 1953 Nov;6(5):269–282. doi: 10.1152/jappl.1953.6.5.269. [DOI] [PubMed] [Google Scholar]
  8. Prechtl H. F., Vlach V., Lenard H. G., Grant D. K. Exteroceptive and tendon reflexes in various behavioural states in the newborn infant. Biol Neonat. 1967;11(3):159–175. doi: 10.1159/000240063. [DOI] [PubMed] [Google Scholar]
  9. Stabell U., Junge M., Fenner A. Metabolic rate and O2 consumption in newborns during different states of vigilance. Biol Neonate. 1977;31(1-2):27–31. doi: 10.1159/000240939. [DOI] [PubMed] [Google Scholar]
  10. Stothers J. K., Warner R. M. Oxygen consumption and sleep state in the new-born [proceedings]. J Physiol. 1977 Jul;269(1):57P–58P. [PubMed] [Google Scholar]
  11. Stothers J. K., Warner R. M. Oxygen consumption of the new-born infant in a cool environment, measured with regard to sleep state [proceedings]. J Physiol. 1977 Oct;272(1):16P–17P. [PubMed] [Google Scholar]
  12. Sulyok E., Jéquier E., Prod'hom L. S. Respiratory contribution to the thermal balance of the newborn infant under various ambient conditions. Pediatrics. 1973 Apr;51(4):641–650. [PubMed] [Google Scholar]

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