Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1980 May;302:183–195. doi: 10.1113/jphysiol.1980.sp013237

Sympathetically evoked secretory potentials in the parotid gland of the cat.

N Emmelin, W Grampp, P Thesleff
PMCID: PMC1282842  PMID: 6106055

Abstract

1. In cats under chloralose anaesthesia micro-electrodes were inserted into parotid gland cells. 2. The average resting potential was found to be -35 . 6 +/- 4 . 7 (S.D.) mV. 3. Stimulation of the auriculo-temporal nerve caused hyperpolarizing, or occasionally depolarizing, secretory potentials of 5--10 mV, which were abolishable with atropine. 4. Stimulation of the cervical sympathetic trunk regularly caused, after long latency (several seconds), slow depolarizations of 15--20 mV, accompanied by a decrease in input resistance. They were antagonized by practolol and therefore assumed to be mediated by beta 1-adrenoceptors. Occasionally hyperpolarization, ascribed to an effect on alpha-adrenoceptors, was observed. 5. In many units the slow depolarization on sympathetic stimulation was preceded by short-lasting hyperpolarizing (sometimes depolarizing) transients. They resembled the evoked cholinergic responses but could be abolished not only by atropine but also by guanethidine.

Full text

PDF
186

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asking B., Delfs U., Emmelin N., Gjörstrup P. Amylase secretion from rat parotid glands as dependent on co-operation between sympathetic and parasympathetic nerves. Experientia. 1979 Oct 15;35(10):1336–1337. doi: 10.1007/BF01963993. [DOI] [PubMed] [Google Scholar]
  2. BURGEN A. S. TECHNIQUES FOR STIMULATING THE AURICULO-TEMPORAL NERVE AND RECORDING THE FLOW OF SALIVA. Int Ser Monogr Oral Biol. 1964;3:303–307. doi: 10.1016/b978-1-4832-2871-6.50026-6. [DOI] [PubMed] [Google Scholar]
  3. Bradford J. R. The Electrical Phenomena accompanying the excitation of so-called Secretory and Trophic Nerve Fibres in the Salivary Glands of the Dog and Cat. J Physiol. 1887 Jun;8(2):86–98. doi: 10.1113/jphysiol.1887.sp000246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cragg B. G. Failure of conduction and of synaptic transmission in degenerating mammalian C fibres. J Physiol. 1965 Jul;179(1):95–112. doi: 10.1113/jphysiol.1965.sp007650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Creed K. E., Wilson J. A. The latency of response of secretory acinar cells to nerve stimulation in the submandibular gland of the cat. Aust J Exp Biol Med Sci. 1969 Feb;47(1):135–144. doi: 10.1038/icb.1969.13. [DOI] [PubMed] [Google Scholar]
  6. EMMELIN N. ACTION OF TRANSMITTERS ON THE RESPONSIVENESS OF EFFECTOR CELLS. Experientia. 1965 Feb 15;21:57–65. doi: 10.1007/BF02144740. [DOI] [PubMed] [Google Scholar]
  7. EMMELIN N. Is there a leakage of acetylcholine from post-ganglionic parasympathetic nerve endings? Nature. 1960 Jan 30;185:297–298. doi: 10.1038/185297a0. [DOI] [PubMed] [Google Scholar]
  8. EMMELIN N., MUREN A., STROMBLAD R. Secretory and vascular effects of various drugs injected into the submaxillary duct. Acta Physiol Scand. 1954 Dec 31;32(4):325–338. doi: 10.1111/j.1748-1716.1954.tb01181.x. [DOI] [PubMed] [Google Scholar]
  9. Ekström J., Emmelin N. The secretory innervation of the parotid gland of the cat: an unexpected component. Q J Exp Physiol Cogn Med Sci. 1974 Jan;59(1):11–17. doi: 10.1113/expphysiol.1974.sp002237. [DOI] [PubMed] [Google Scholar]
  10. Emmelin N., Garrett J. R., Ohlin P. Neural control of salivary myoepithelial cells. J Physiol. 1968 May;196(2):381–396. doi: 10.1113/jphysiol.1968.sp008513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Emmelin N., Gjörstrup P. Secretory responses to sympathetic stimulation of the cat's salivary glands in a state of resting secretion. Q J Exp Physiol Cogn Med Sci. 1975 Oct;60(4):325–332. doi: 10.1113/expphysiol.1975.sp002326. [DOI] [PubMed] [Google Scholar]
  12. Fritz M. E., Botelho S. Y. Membrane potentials in unstimulated parotid gland of the cat. Am J Physiol. 1969 May;216(5):1180–1183. doi: 10.1152/ajplegacy.1969.216.5.1180. [DOI] [PubMed] [Google Scholar]
  13. Fritz M. E., Botelho S. Y. Role of autonomic nerve impulses in secretion by the parotid gland of the cat. Am J Physiol. 1969 Jun;216(6):1392–1398. doi: 10.1152/ajplegacy.1969.216.6.1392. [DOI] [PubMed] [Google Scholar]
  14. Fritz M. E. Functional innervation of rabbit salivary gland. Proc Soc Exp Biol Med. 1971 Jul;137(3):776–779. doi: 10.3181/00379727-137-35664. [DOI] [PubMed] [Google Scholar]
  15. Fritz M. E., Grampp W. The action of dibutyryl adenosine-3':5'-cyclic monophosphoric acid and theophylline on the isolated cat parotid gland. Acta Physiol Scand. 1975 Mar;93(3):352–363. doi: 10.1111/j.1748-1716.1975.tb05824.x. [DOI] [PubMed] [Google Scholar]
  16. Kagayama M., Nishiyama A. Membrane potential and input resistance in acinar cells from cat and rabbit submaxillary glands in vivo: effects of autonomic nerve stimulation. J Physiol. 1974 Oct;242(1):157–172. doi: 10.1113/jphysiol.1974.sp010699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LUNDBERG A. The electrophysiology of the submaxillary gland of the cat. Acta Physiol Scand. 1955 Dec 22;35(1):1–25. doi: 10.1111/j.1748-1716.1955.tb01258.x. [DOI] [PubMed] [Google Scholar]
  18. OHLIN P., STROMBLAD B. C. Supersensitivity of the vessels of the parotid gland after denervation. Br J Pharmacol Chemother. 1958 Sep;13(3):227–230. doi: 10.1111/j.1476-5381.1958.tb00895.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Petersen O. H. Electrophysiology of mammalian gland cells. Physiol Rev. 1976 Jul;56(3):535–577. doi: 10.1152/physrev.1976.56.3.535. [DOI] [PubMed] [Google Scholar]
  20. Petersen O. H., Pedersen G. L. Membrane effects mediated by alpha-and beta-adrenoceptors in mouse parotid acinar cells. J Membr Biol. 1974;16(4):353–362. doi: 10.1007/BF01872423. [DOI] [PubMed] [Google Scholar]
  21. RICHINS C. A., KUNTZ A. Role of sympathetic nerves in the regulation of salivary secretion. Am J Physiol. 1953 Jun;173(3):470–473. doi: 10.1152/ajplegacy.1953.173.3.471. [DOI] [PubMed] [Google Scholar]
  22. STROMBLAD R. Sensitivity of the normal and denervated parotid gland to chemical agents. Acta Physiol Scand. 1955 Feb 16;33(1):83–98. doi: 10.1111/j.1748-1716.1955.tb01195.x. [DOI] [PubMed] [Google Scholar]
  23. Thulin A. Influence of autonomic nerves and drugs on myoepithelial cells in parotid glands of cat. Acta Physiol Scand. 1975 Apr;93(4):477–482. doi: 10.1111/j.1748-1716.1975.tb05838.x. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES