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. 1980 Oct;307:71–83. doi: 10.1113/jphysiol.1980.sp013424

Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

S Swaminathan
PMCID: PMC1283034  PMID: 7205680

Abstract

1. ADH secretion was studied in trained, preoperated conscious monkeys undergoing water diuresis after administration of isosmolar hypertonic solutions of different substances into any one of the following sites: (i) anterior third ventricle, (ii) the hypothalamus, just anterior to the third ventricle and (iii) common carotid artery. 2. Free water clearance was continuously monitored and the ADH released was measured by bio-assay on the same animals after administering graded doses of standard arginine vasopressin in a comparable manner. 3. Intraventricular infusions of hypertonic solutions of NaCl or Na acetate released significant amounts of ADH while sucrose or mannitol of comparable osmolality were ineffective. Graded increases in the concentration of NaCl infused into the c.s.f. resulted in secretion of ADH proportional to log Na concentration. 4. Infusion of the same hypertonic solutions into the anterior hypothalamus released ADH, though Na salts were more effective than the sugars. 5. Hypertonic solutions of NaCl, Na acetate, sucrose or mannitol were effective in releasing ADH when injected via the carotid artery, but hypertonic solutions of NaCl were significantly more effective than the other solutions. 6. These findings may be explained by the hypothesis that the 'osmoreceptors' of Verney are Na sensitive receptors composed of dendrites innervating the specialized ependyma of the anterior part of the third ventricle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson B., Jobin M., Olsson K. A study of thirst and other effects of an increased sodium concentration in the 3rd brain ventricle. Acta Physiol Scand. 1967 Jan-Feb;69(1):29–36. doi: 10.1111/j.1748-1716.1967.tb03488.x. [DOI] [PubMed] [Google Scholar]
  2. Andersson B., Olsson K., Warner R. G. Dissimilarities between the central control of thirst and the release of antidiuretic hormone (ADH). Acta Physiol Scand. 1967 Sep;71(1):57–64. doi: 10.1111/j.1748-1716.1967.tb03709.x. [DOI] [PubMed] [Google Scholar]
  3. Andersson B. Regulation of body fluids. Annu Rev Physiol. 1977;39:185–200. doi: 10.1146/annurev.ph.39.030177.001153. [DOI] [PubMed] [Google Scholar]
  4. Blaine E. H., Denton D. A., McKinley M. J., Weller S. A central osmosensitive receptor for renal sodium excretion. J Physiol. 1975 Jan;244(2):497–509. doi: 10.1113/jphysiol.1975.sp010809. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bleier R. The relations of ependyma to neurons and capillaries in the hypothalamus: a Golgi-Cox study. J Comp Neurol. 1971 Aug;142(4):439–463. doi: 10.1002/cne.901420404. [DOI] [PubMed] [Google Scholar]
  6. CRONE C. THE PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF THE 'INDICATOR DIFFUSION' METHOD. Acta Physiol Scand. 1963 Aug;58:292–305. doi: 10.1111/j.1748-1716.1963.tb02652.x. [DOI] [PubMed] [Google Scholar]
  7. DIERICKX K. The dendrites of the preoptic neurosecretory nucleus of Rana temporaria and the osmoreceptors. Arch Int Pharmacodyn Ther. 1962 Dec 1;140:708–725. [PubMed] [Google Scholar]
  8. Eriksson L. Effect of lowered CSF sodium concentration on the central control of fluid balance. Acta Physiol Scand. 1974 May;91(1):61–68. doi: 10.1111/j.1748-1716.1974.tb05657.x. [DOI] [PubMed] [Google Scholar]
  9. Eriksson L., Fernández O., Olsson K. Differences in the antidiuretic response to intracarotid infusions of various hypertonic solutions in the conscious goat. Acta Physiol Scand. 1971 Dec;83(4):554–562. doi: 10.1111/j.1748-1716.1971.tb05113.x. [DOI] [PubMed] [Google Scholar]
  10. FROHLICH E. D. VASCULAR EFFECTS OF THE KREBS INTERMEDIATE METABOLITES. Am J Physiol. 1965 Jan;208:149–153. doi: 10.1152/ajplegacy.1965.208.1.149. [DOI] [PubMed] [Google Scholar]
  11. Fenstermacher J. D., Johnson J. A. Filtration and reflection coefficients of the rabbit blood-brain barrier. Am J Physiol. 1966 Aug;211(2):341–346. doi: 10.1152/ajplegacy.1966.211.2.341. [DOI] [PubMed] [Google Scholar]
  12. HEISEY S. R., HELD D., PAPPENHEIMER J. R. Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol. 1962 Nov;203:775–781. doi: 10.1152/ajplegacy.1962.203.5.775. [DOI] [PubMed] [Google Scholar]
  13. Hayward J. N. Functional and morphological aspects of hypothalamic neurons. Physiol Rev. 1977 Jul;57(3):574–658. doi: 10.1152/physrev.1977.57.3.574. [DOI] [PubMed] [Google Scholar]
  14. Hayward J. N., Jennings D. P. Osmosensitivity of hypothalamic magnocellular neuroendocrine cells to intracarotid hypertonic D-glucose in the waking monkey. Brain Res. 1973 Jul 27;57(2):467–472. doi: 10.1016/0006-8993(73)90151-0. [DOI] [PubMed] [Google Scholar]
  15. Hayward J. N. Physiological and morphological identification of hypothalamic magnocellular neuroendocrine cells in goldfish preoptic nucleus. J Physiol. 1974 May;239(1):103–124. doi: 10.1113/jphysiol.1974.sp010558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Holbert R. D., Pearson J. E., Gonzalez F. M. Effect of sodium acetate infusion on renal function in the dog. Arch Int Pharmacodyn Ther. 1976 Feb;219(2):211–222. [PubMed] [Google Scholar]
  17. Kumar M. A., Swaminathan S. Search for a natriuretic mechanism sensitive to sodium in the brain of the monkey. J Physiol. 1977 Nov;272(3):563–572. doi: 10.1113/jphysiol.1977.sp012060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. McKinley M. J., Denton D. A., Weisinger R. S. Sensors for antidiuresis and thirst--osmoreceptors or CSF sodium detectors? Brain Res. 1978 Feb 3;141(1):89–103. doi: 10.1016/0006-8993(78)90619-4. [DOI] [PubMed] [Google Scholar]
  19. Milhorat T. H., Hammock M. K., Fenstermacher J. D., Levin V. A. Cerebrospinal fluid production by the choroid plexus and brain. Science. 1971 Jul 23;173(3994):330–332. doi: 10.1126/science.173.3994.330. [DOI] [PubMed] [Google Scholar]
  20. Olsson K. Studies on central regulation of secretion of antidiuretic hormone (ADH) in the goat. Acta Physiol Scand. 1969 Dec;77(4):465–474. doi: 10.1111/j.1748-1716.1969.tb04590.x. [DOI] [PubMed] [Google Scholar]
  21. SMOLLER C. G. NEUROSECRETORY PROCESSES EXTENDING INTO THIRD VENTRICLE: SECRETORY OR SENSORY? Science. 1965 Feb 19;147(3660):882–884. doi: 10.1126/science.147.3660.882. [DOI] [PubMed] [Google Scholar]
  22. Weindl A., Joynt R. J. Ultrastructure of the ventricular walls. Three-dimensional study of regional specialization. Arch Neurol. 1972 May;26(5):420–427. doi: 10.1001/archneur.1972.00490110054005. [DOI] [PubMed] [Google Scholar]

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