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Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1986 Jan;79(1):25–29. doi: 10.1177/014107688607900109

Optic nerve hypoplasia in infancy.

A R Fielder, M I Levene, J Q Trounce, M S Tanner
PMCID: PMC1290142  PMID: 3511258

Abstract

Certain features of optic nerve hypoplasia (ONH), its systemic associations and investigation are exclusive to infancy. These include the facility to use cranial ultrasound, difficulties in assessing ocular features and visual function, and neonatal hypoglycaemia and jaundice. Six infants with ONH are presented; cerebral abnormalities were demonstrated by cranial ultrasound in five. Neonatal cholestatic jaundice and hypoglycaemia occurred in one infant. Two died and represent a group likely to remain undetected unless routine ophthalmic examination of neurologically abnormal neonates is undertaken. In infancy, both ocular and systemic aspects of ONH can be investigated simply and without sedation.

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Selected References

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  1. Acers T. E. Optic nerve hypoplasia: septo-optic-pituitary dysplasia syndrome. Trans Am Ophthalmol Soc. 1981;79:425–457. [PMC free article] [PubMed] [Google Scholar]
  2. Brook C. G., Sanders M. D., Hoare R. D. Septo-optic dysplasia. Br Med J. 1972 Sep 30;3(5830):811–813. doi: 10.1136/bmj.3.5830.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Copeland K. C., Franks R. C., Ramamurthy R. Neonatal hyperbilirubinemia and hypoglycemia in congenital hypopituitarism. Clin Pediatr (Phila) 1981 Aug;20(8):523–526. doi: 10.1177/000992288102000808. [DOI] [PubMed] [Google Scholar]
  4. Elster A. B., McAnarney E. R. Maternal age re septo-optic dysplasia. J Pediatr. 1979 Jan;94(1):162–163. doi: 10.1016/s0022-3476(79)80392-3. [DOI] [PubMed] [Google Scholar]
  5. Frisén L., Holmegaard L. Spectrum of optic nerve hypoplasia. Br J Ophthalmol. 1978 Jan;62(1):7–15. doi: 10.1136/bjo.62.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harris R. J., Haas L. Septo-optic dysplasia with growth hormone deficiency (De Morsier syndrome). Arch Dis Child. 1972 Dec;47(256):973–976. doi: 10.1136/adc.47.256.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoyt C. S., Billson F. A. Maternal anticonvulsants and optic nerve hypoplasia. Br J Ophthalmol. 1978 Jan;62(1):3–6. doi: 10.1136/bjo.62.1.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hoyt C. S. The clinical usefulness of the visual evoked response. J Pediatr Ophthalmol Strabismus. 1984 Nov-Dec;21(6):231–234. doi: 10.3928/0191-3913-19841101-08. [DOI] [PubMed] [Google Scholar]
  9. Kaufman F. R., Costin G., Thomas D. W., Sinatra F. R., Roe T. F., Neustein H. B. Neonatal cholestasis and hypopituitarism. Arch Dis Child. 1984 Aug;59(8):787–789. doi: 10.1136/adc.59.8.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Krause-Brucker W., Gardner D. W. Optic nerve hypoplasia associated with absent septum pellucidum and hypopituitarism. Am J Ophthalmol. 1980 Jan;89(1):113–120. doi: 10.1016/0002-9394(80)90237-8. [DOI] [PubMed] [Google Scholar]
  11. Margalith D., Jan J. E., McCormick A. Q., Tze W. J., Lapointe J. Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients. Dev Med Child Neurol. 1984 Jun;26(3):311–322. doi: 10.1111/j.1469-8749.1984.tb04447.x. [DOI] [PubMed] [Google Scholar]
  12. McKinna A. J. Quinine induced hypoplasia of the optic nerve. Can J Ophthalmol. 1966 Oct;1(4):261–266. [PubMed] [Google Scholar]
  13. Patel H., Tze W. J., Crichton J. U., McCormick A. Q., Robinson G. C., Dolman C. L. Optic nerve hypoplasia with hypopituitarism. Septo-optic dysplasia with hypopituitarism. Am J Dis Child. 1975 Feb;129(2):175–180. doi: 10.1001/archpedi.1975.02120390017004. [DOI] [PubMed] [Google Scholar]
  14. Petersen R. A., Walton D. S. Optic nerve hypoplasia with good visual acuity and visual field defects: a study of children of diabetic mothers. Arch Ophthalmol. 1977 Feb;95(2):254–258. doi: 10.1001/archopht.1977.04450020055011. [DOI] [PubMed] [Google Scholar]
  15. Rogers G. L., Brown D., Gray I., Bremer D. Bilateral optic nerve hypoplasia associated with cerebral atrophy. J Pediatr Ophthalmol Strabismus. 1981 Nov-Dec;18(6):18–22. doi: 10.3928/0191-3913-19811101-06. [DOI] [PubMed] [Google Scholar]
  16. Skarf B., Hoyt C. S. Optic nerve hypoplasia in children. Association with anomalies of the endocrine and CNS. Arch Ophthalmol. 1984 Jan;102(1):62–67. doi: 10.1001/archopht.1984.01040030046032. [DOI] [PubMed] [Google Scholar]
  17. Stanhope R., Preece M. A., Brook C. G. Hypoplastic optic nerves and pituitary dysfunction. A spectrum of anatomical and endocrine abnormalities. Arch Dis Child. 1984 Feb;59(2):111–114. doi: 10.1136/adc.59.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tanner M. S., Fielder A. R. Hypoplastic optic nerves and pituitary dysfunction. Arch Dis Child. 1984 Jul;59(7):691–691. doi: 10.1136/adc.59.7.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Van Dyk H. J., Morgan K. S. Optic nerve hypoplasia and young maternal age. Am J Ophthalmol. 1980 Jun;89(6):879–879. doi: 10.1016/0002-9394(80)90189-0. [DOI] [PubMed] [Google Scholar]

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