Abstract
Gastro-oesophageal reflux (GOR) occurs frequently in children with cystic fibrosis (CF) but has not been studied in adult CF. We surveyed such symptoms by structured questionnaire in 50 adult CF patients (mean age 26 years, range 16-50; 24 male) and performed oesophageal manometry and 24-hour pH recording in 10 who had reflux symptoms (mean age 28 years, range 21-35; 8 men). 47 patients (94%) had upper gastrointestinal symptoms: 40 (80%) heartburn (27 worse when supine); 26 (52%) regurgitation; and 28 (56%) dyspepsia. At oesophageal manometry, lower oesophageal sphincter barrier pressure (LOSBP) was subnormal in 6 of the 10 patients and 3 had uncoordinated peristalsis in the mid oesophagus. 8 patients had raised DeMeester scores, indicating significant GOR. Those patients with a LOSBP < 5mm Hg had a higher DeMeester score (mean 81.0, range 47.9-128.8) than the patients with a normal LOSBP (26.9, 8.7-56.5; p < 0.002). These results show that adult CF patients have high rates of GOR symptoms, diminished LOSBP, and acid reflux.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dent J., Dodds W. J., Hogan W. J., Toouli J. Factors that influence induction of gastroesophageal reflux in normal human subjects. Dig Dis Sci. 1988 Mar;33(3):270–275. doi: 10.1007/BF01535748. [DOI] [PubMed] [Google Scholar]
- Dent J., Holloway R. H., Toouli J., Dodds W. J. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux. Gut. 1988 Aug;29(8):1020–1028. doi: 10.1136/gut.29.8.1020. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dodds W. J., Hogan W. J., Helm J. F., Dent J. Pathogenesis of reflux esophagitis. Gastroenterology. 1981 Aug;81(2):376–394. [PubMed] [Google Scholar]
- Dodds W. J., Stef J. J., Hogan W. J. Factors determining pressure measurement accuracy by intraluminal esophageal manometry. Gastroenterology. 1976 Jan;70(1):117–123. [PubMed] [Google Scholar]
- Hadorn B., Johansen P. G., Anderson C. M. Pancreozymin secretin test of exocrine pancreatic funtion in cystic fribrosis and the significance of the result for the pathogenesis of the disease. Can Med Assoc J. 1968 Feb 24;98(8):377–385. [PMC free article] [PubMed] [Google Scholar]
- Hollwarth M. E., Smith M., Kvietys P. R., Granger D. N. Esophageal blood flow in the cat. Normal distribution and effects of acid perfusion. Gastroenterology. 1986 Mar;90(3):622–627. doi: 10.1016/0016-5085(86)91116-9. [DOI] [PubMed] [Google Scholar]
- Scott R. B., O'Loughlin E. V., Gall D. G. Gastroesophageal reflux in patients with cystic fibrosis. J Pediatr. 1985 Feb;106(2):223–227. doi: 10.1016/s0022-3476(85)80291-2. [DOI] [PubMed] [Google Scholar]
- Werlin S. L., Dodds W. J., Hogan W. J., Arndorfer R. C. Mechanisms of gastroesophageal reflux in children. J Pediatr. 1980 Aug;97(2):244–249. doi: 10.1016/s0022-3476(80)80482-3. [DOI] [PubMed] [Google Scholar]