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. 1985;83:610–663.

Inflammatory mechanisms in corneal ulceration.

K R Kenyon
PMCID: PMC1298713  PMID: 3914132

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONSON S. B., GOODNER E. K., YAMAMOTO E., FOREMAN M. MECHANISMS OF THE HOST RESPONSE IN THE EYE.I. CHANGES IN THE ANTERIOR EYE FOLLOWING IMMUNIZATION TO A HETEROLOGOUS ANTIGEN. Arch Ophthalmol. 1965 Mar;73:402–412. doi: 10.1001/archopht.1965.00970030404020. [DOI] [PubMed] [Google Scholar]
  2. Aronson S. B., Elliott J. H., Moore T. E., Jr, O'Day D. M. Pathogenetic approach to therapy of peripheral corneal inflammatory disease. Am J Ophthalmol. 1970 Jul;70(1):65–90. doi: 10.1016/0002-9394(70)90670-7. [DOI] [PubMed] [Google Scholar]
  3. Aronson S. B., Martenet A. C., Yamamoto E. A., Bedford M. J. Mechanisms of the host response in the eye. II. Variations in ocular disease produced by several different antigens. Arch Ophthalmol. 1966 Aug;76(2):266–273. doi: 10.1001/archopht.1966.03850010268019. [DOI] [PubMed] [Google Scholar]
  4. Aronson S. B., Moore T. E., Jr Corticosteroid therapy in central stromal keratitis. Am J Ophthalmol. 1969 Jun;67(6):873–896. doi: 10.1016/0002-9394(69)90082-8. [DOI] [PubMed] [Google Scholar]
  5. Berman Collagenase inhibitors: rationale for their use in treating corneal ulceration. Int Ophthalmol Clin. 1975 Winter;15(4):49–66. doi: 10.1097/00004397-197501540-00006. [DOI] [PubMed] [Google Scholar]
  6. Berman M. B., Cavanagh H. D., Gage J. 5' Adenosine memophosphate prevents collagen degradation in culture but does not prevent corneal ulceration. Exp Eye Res. 1977 Apr;24(4):391–397. doi: 10.1016/0014-4835(77)90152-x. [DOI] [PubMed] [Google Scholar]
  7. Berman M. B., Manabe R., Davison P. F. Tissue collagenase: a simplified, semiquantitative enzyme assay. Anal Biochem. 1973 Aug;54(2):522–534. doi: 10.1016/0003-2697(73)90384-9. [DOI] [PubMed] [Google Scholar]
  8. Berman M., Dohlman C. H., Gnädinger M., Davison P. Characterization of collagenolytic activity in the ulcerating cornea. Exp Eye Res. 1971 Mar;11(2):255–257. doi: 10.1016/s0014-4835(71)80030-1. [DOI] [PubMed] [Google Scholar]
  9. Berman M., Dohlman C. Collagenase inhibitors. Arch Ophtalmol Rev Gen Ophtalmol. 1975 Jan;35(1):95–112. [PubMed] [Google Scholar]
  10. Berman M., Leary R., Gage J. Evidence for a role of the plasminogen activator--plasmin system in corneal ulceration. Invest Ophthalmol Vis Sci. 1980 Oct;19(10):1204–1221. [PubMed] [Google Scholar]
  11. Berman M. Regulation of collagenase. Therapeutic considerations. Trans Ophthalmol Soc U K. 1978 Sep;98(3):397–405. [PubMed] [Google Scholar]
  12. Bonta I. L., Parnham M. J., Van Vliet L. Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats. Ann Rheum Dis. 1978 Jun;37(3):212–217. doi: 10.1136/ard.37.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Bowman K. A., Green K. Corneal epithelial healing rates after topical nucleotides. Curr Eye Res. 1981;1(10):619–622. doi: 10.3109/02713688109001864. [DOI] [PubMed] [Google Scholar]
  14. Brinckerhoff C. E., McMillan R. M., Dayer J. M., Harris E. D., Jr Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells. N Engl J Med. 1980 Aug 21;303(8):432–436. doi: 10.1056/NEJM198008213030805. [DOI] [PubMed] [Google Scholar]
  15. Brown S. I., Weller C. A., Akiya S. Pathogenesis of ulcers of the alkali-burned cornea. Arch Ophthalmol. 1970 Feb;83(2):205–208. doi: 10.1001/archopht.1970.00990030207014. [DOI] [PubMed] [Google Scholar]
  16. Brown S. I., Weller C. A. The pathogenesis and treatment of collagenase-induced diseases of the cornea. Trans Am Acad Ophthalmol Otolaryngol. 1970 Mar-Apr;74(2):375–383. [PubMed] [Google Scholar]
  17. Brown S. I., Weller C. A., Wassermann H. E. Collagenolytic activity of alkali-burned corneas. Arch Ophthalmol. 1969 Mar;81(3):370–373. doi: 10.1001/archopht.1969.00990010372015. [DOI] [PubMed] [Google Scholar]
  18. Cavanagh H. D., Pihlaja D., Thoft R. A., Dohlman C. H. The pathogenesis and treatment of persistent epithelial defects. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Sep-Oct;81(5):754–769. [PubMed] [Google Scholar]
  19. Cogan D. G., Kuwabara T., Donaldson D. D., Collins E. Microcystic dystrophy of the cornea. A partial explanation for its pathogenesis. Arch Ophthalmol. 1974 Dec;92(6):470–474. doi: 10.1001/archopht.1974.01010010484004. [DOI] [PubMed] [Google Scholar]
  20. Conn H., Berman M., Kenyon K., Langer R., Gage J. Stromal vascularization prevents corneal ulceration. Invest Ophthalmol Vis Sci. 1980 Apr;19(4):362–370. [PubMed] [Google Scholar]
  21. Donshik P. C., Berman M. B., Dohlman C. H., Gage J., Rose J. Effect of topical corticosteroids on ulceration in alkali-burned corneas. Arch Ophthalmol. 1978 Nov;96(11):2117–2120. doi: 10.1001/archopht.1978.03910060497024. [DOI] [PubMed] [Google Scholar]
  22. Easty D. L., Madden P., Jayson M. I., Carter C., Noble B. A. Systemic immunosuppression in marginal keratolysis. Trans Ophthalmol Soc U K. 1978 Sep;98(3):410–417. [PubMed] [Google Scholar]
  23. Fogle J. A., Kenyon K. R., Foster C. S. Tissue adhesive arrests stromal melting in the human cornea. Am J Ophthalmol. 1980 Jun;89(6):795–802. doi: 10.1016/0002-9394(80)90168-3. [DOI] [PubMed] [Google Scholar]
  24. Fogle J. A., Kenyon K. R., Stark W. J. Damage to epithelial basement membrane by thermokeratoplasty. Am J Ophthalmol. 1977 Mar;83(3):392–401. doi: 10.1016/0002-9394(77)90739-5. [DOI] [PubMed] [Google Scholar]
  25. Fogle J. A., Kenyon K. R., Stark W. J., Green W. R. Defective epithelial adhesion in anterior corneal dystrophies. Am J Ophthalmol. 1975 Jun;79(6):925–940. doi: 10.1016/0002-9394(75)90674-1. [DOI] [PubMed] [Google Scholar]
  26. Foster C. S. Immunosuppressive therapy for external ocular inflammatory disease. Ophthalmology. 1980 Feb;87(2):140–150. doi: 10.1016/s0161-6420(80)35272-x. [DOI] [PubMed] [Google Scholar]
  27. Foster C. S., Kenyon K. R., Greiner J., Greineder D. K., Friedland B., Allansmith M. R. The immunopathology of Mooren's ulcer. Am J Ophthalmol. 1979 Aug;88(2):149–159. doi: 10.1016/0002-9394(79)90459-8. [DOI] [PubMed] [Google Scholar]
  28. Foster C. S., Zelt R. P., Mai-Phan T., Kenyon K. R. Immunosuppression and selective inflammatory cell depletion. Studies on a guinea pig model of corneal ulceration after ocular alkali burning. Arch Ophthalmol. 1982 Nov;100(11):1820–1824. doi: 10.1001/archopht.1982.01030040800019. [DOI] [PubMed] [Google Scholar]
  29. Freedman H. L., Listgarten M. A., Taichman N. S. Electron microscopic features of chronically inflamed human gingiva. J Periodontal Res. 1968;3(4):313–327. doi: 10.1111/j.1600-0765.1968.tb01937.x. [DOI] [PubMed] [Google Scholar]
  30. Gipson I. K., Keezer L. Effects of cytochalasins and colchicine on the ultrastructure of migrating corneal epithelium. Invest Ophthalmol Vis Sci. 1982 May;22(5):643–650. [PubMed] [Google Scholar]
  31. Grant L., Ross M. H., Moses J., Prose P., Zweifach B. W., Ebert R. H. The extravascular nature of Arthus reactions elicited by ferritin. A combined light and electron microscopic analysis of immune states in rabbit ear chambers and mesenteries. Z Zellforsch Mikrosk Anat. 1967;77(4):554–588. doi: 10.1007/BF00319348. [DOI] [PubMed] [Google Scholar]
  32. Hirst L. W., Fogle J. A., Kenyon K. R., Stark W. J. Corneal epithelial regeneration and adhesion following acid burns in the rhesus monkey. Invest Ophthalmol Vis Sci. 1982 Dec;23(6):764–773. [PubMed] [Google Scholar]
  33. Hirst L. W., Kenyon K. R., Fogle J. A., Hanninen L., Stark W. J. Comparative studies of corneal surface injury in the monkey and rabbit. Arch Ophthalmol. 1981 Jun;99(6):1066–1073. doi: 10.1001/archopht.1981.03930011066017. [DOI] [PubMed] [Google Scholar]
  34. Hook R. M., Hook C. W., Brown S. I. Fibroblast collagenase partial purification and characterization. Invest Ophthalmol. 1973 Oct;12(10):771–776. [PubMed] [Google Scholar]
  35. Hunninghake G. W., Fauci A. S. Quantitative and qualitative effects of cyclophosphamide administration on circulating polymorphonuclear leucocytes. Immunology. 1976 Jul;31(1):139–144. [PMC free article] [PubMed] [Google Scholar]
  36. Ignarro L. J. Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides. Arthritis Rheum. 1974 Jan-Feb;17(1):25–36. doi: 10.1002/art.1780170106. [DOI] [PubMed] [Google Scholar]
  37. Janoff A. Mediators of tissue damage in leukocyte lysosomes. X. Further studies on human granulocyte elastase. Lab Invest. 1970 Mar;22(3):228–236. [PubMed] [Google Scholar]
  38. Janoff A., Zeligs J. D. Vascular injury and lysis of basement membrane in vitro by neutral protease of human leukocytes. Science. 1968 Aug 16;161(3842):702–704. doi: 10.1126/science.161.3842.702. [DOI] [PubMed] [Google Scholar]
  39. Johnson-Muller B., Gross J. Regulation of corneal collagenase production: epithelial-stromal cell interactions. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4417–4421. doi: 10.1073/pnas.75.9.4417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Johnson-Wint B. Regulation of stromal cell collagenase production in adult rabbit cornea: in vitro stimulation and inhibition by epithelial cell products. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5331–5335. doi: 10.1073/pnas.77.9.5331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Johnson G. S., Morgan W. D., Pastan I. Regulation of cell motility by cyclic AMP. Nature. 1972 Jan 7;235(5332):54–56. doi: 10.1038/235054a0. [DOI] [PubMed] [Google Scholar]
  42. Johnson G. S., Pastan I. N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells. Nat New Biol. 1972 Jun 28;237(78):267–268. doi: 10.1038/newbio237267a0. [DOI] [PubMed] [Google Scholar]
  43. Jumblatt M. M., Fogle J. A., Neufeld A. H. Cholera toxin stimulates adenosine 3',5'-monophosphate synthesis and epithelial wound closure in the rabbit cornea. Invest Ophthalmol Vis Sci. 1980 Nov;19(11):1321–1327. [PubMed] [Google Scholar]
  44. Keiser H., Greenwald R. A., Feinstein G., Janoff A. Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan. J Clin Invest. 1976 Mar;57(3):625–632. doi: 10.1172/JCI108318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Kenyon K. R., Berman M., Rose J., Gage J. Prevention of stromal ulceration in the alkali-burned rabbit cornea by glued-on contact lens. Evidence for the role of polymorphonuclear leukocytes in collagen degradation. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):570–587. [PubMed] [Google Scholar]
  46. Kenyon K. R. Decision-making in the therapy of external eye disease: noninfected corneal ulcers. Ophthalmology. 1982 Jan;89(1):44–51. doi: 10.1016/s0161-6420(82)34860-5. [DOI] [PubMed] [Google Scholar]
  47. Kenyon K. R., Fogle J. A., Stone D. L., Stark W. J. Regeneration of corneal epithelial basement membrane following thermal cauterization. Invest Ophthalmol Vis Sci. 1977 Apr;16(4):292–301. [PubMed] [Google Scholar]
  48. Kenyon K. R. The synthesis of basement membrane by the corneal epithelium in bullous keratopathy. Invest Ophthalmol. 1969 Apr;8(2):156–168. [PubMed] [Google Scholar]
  49. Khodadoust A. A., Silverstein A. M., Kenyon D. R., Dowling J. E. Adhesion of regenerating corneal epithelium. The role of basement membrane. Am J Ophthalmol. 1968 Mar;65(3):339–348. doi: 10.1016/0002-9394(68)93082-1. [DOI] [PubMed] [Google Scholar]
  50. Koob T. J., Jeffrey J. J., Eisen A. Z. Regulation of human skin collagenase activity by hydrocortisone and dexamethasone in organ culture. Biochem Biophys Res Commun. 1974 Dec 11;61(3):1083–1088. doi: 10.1016/0006-291x(74)90266-6. [DOI] [PubMed] [Google Scholar]
  51. Lazarus G. S., Brown R. S., Daniels J. R., Fullmer H. M. Human granulocyte collagenase. Science. 1968 Mar 29;159(3822):1483–1485. doi: 10.1126/science.159.3822.1483. [DOI] [PubMed] [Google Scholar]
  52. Lazarus G. S., Daniels J. R., Lian J., Burleigh M. C. Role of granulocyte collagenase in collagen degradation. Am J Pathol. 1972 Sep;68(3):565–578. [PMC free article] [PubMed] [Google Scholar]
  53. Lichtenstein L. M., Gillespie E., Bourne H. R., Henney C. S. The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins. 1972 Dec;2(6):519–528. doi: 10.1016/s0090-6980(72)80040-6. [DOI] [PubMed] [Google Scholar]
  54. McCulley J. P., Slansky H. H., Pavan-Langston D., Dohlman C. H. Collagenolytic activity in experimental herpes simplex keratitis. Arch Ophthalmol. 1970 Oct;84(4):516–519. doi: 10.1001/archopht.1970.00990040518023. [DOI] [PubMed] [Google Scholar]
  55. McDonald T. O., Borgmann A. R., Roberts M. D., Fox L. G. Corneal wound healing. I. Inhibition of stromal healing by three dexamethasone derivatives. Invest Ophthalmol. 1970 Sep;9(9):703–709. [PubMed] [Google Scholar]
  56. Miller D., Gruenberg P., Miller R., Bergamini M. V. Topical flurbiprofen or prednisolone. Effect on corneal wound healing in rabbits. Arch Ophthalmol. 1981 Apr;99(4):681–682. doi: 10.1001/archopht.1981.03930010681016. [DOI] [PubMed] [Google Scholar]
  57. Mohos S. C., Wagner B. M. Damage to collagen in corneal immune injury. Observation of connective tissue structure. Arch Pathol. 1969 Jul;88(1):3–20. [PubMed] [Google Scholar]
  58. Murphy G., Bretz U., Baggiolini M., Reynolds J. J. The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes. Biochem J. 1980 Nov 15;192(2):517–525. doi: 10.1042/bj1920517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Murphy G., Reynolds J. J., Bretz U., Baggiolini M. Collagenase is a component of the specific granules of human neutrophil leucocytes. Biochem J. 1977 Jan 15;162(1):195–197. doi: 10.1042/bj1620195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Neufeld A. H., Sears M. L. Cyclic-AMP in ocular tissues of the rabbit, monkey, and human. Invest Ophthalmol. 1974 Jun;13(6):475–477. [PubMed] [Google Scholar]
  61. Newsome N. A., Gross J. Prevention by medroxyprogesterone of perforation in the alkali-burned rabbit cornea: inhibition of collagenolytic activity. Invest Ophthalmol Vis Sci. 1977 Jan;16(1):21–31. [PubMed] [Google Scholar]
  62. Nishida T., Nakagawa S., Nishibayashi C., Tanaka H., Manabe R. Fibronectin enhancement of corneal epithelial wound healing of rabbits in vivo. Arch Ophthalmol. 1984 Mar;102(3):455–456. doi: 10.1001/archopht.1984.01040030369040. [DOI] [PubMed] [Google Scholar]
  63. Nishida T., Ohashi Y., Awata T., Manabe R. Fibronectin. A new therapy for corneal trophic ulcer. Arch Ophthalmol. 1983 Jul;101(7):1046–1048. doi: 10.1001/archopht.1983.01040020048007. [DOI] [PubMed] [Google Scholar]
  64. O'Day D. M. Structural alteration and destructive corneal disease. Trans Ophthalmol Soc U K. 1978 Sep;98(3):352–356. [PubMed] [Google Scholar]
  65. Olsson I., Venge P. The role of the human neutrophil in the inflammatory reaction. Allergy. 1980 Jan;35(1):1–13. doi: 10.1111/j.1398-9995.1980.tb01711.x. [DOI] [PubMed] [Google Scholar]
  66. Pandolfi M., Lantz E. Partial purification and characterization of keratokinase, the fibrinolytic activator of the cornea. Exp Eye Res. 1979 Nov;29(5):563–571. doi: 10.1016/0014-4835(79)90156-8. [DOI] [PubMed] [Google Scholar]
  67. Pfister R. R., McCulley J. P., Friend J., Dohlman C. H. Collagenase activity of intact corneal epithelium in peripheral alkali burns. Arch Ophthalmol. 1971 Sep;86(3):308–313. doi: 10.1001/archopht.1971.01000010310014. [DOI] [PubMed] [Google Scholar]
  68. Pfister R. R., Nicolaro M. L., Paterson C. A. Sodium citrate reduces the incidence of corneal ulcerations and perforations in extreme alkali-burned eyes--acetylcysteine and ascorbate have no favorable effect. Invest Ophthalmol Vis Sci. 1981 Sep;21(3):486–490. [PubMed] [Google Scholar]
  69. Pfister R. R., Paterson C. A. Additional clinical and morphological observations on the favorable effect of ascorbate in experimental ocular alkali burns. Invest Ophthalmol Vis Sci. 1977 Jun;16(6):478–487. [PubMed] [Google Scholar]
  70. Pfister R. R., Paterson C. A., Hayes S. A. Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns. Invest Ophthalmol Vis Sci. 1978 Oct;17(10):1019–1024. [PubMed] [Google Scholar]
  71. Phan T. M., Zelt R. P., Kenyon K. R., Chakrabarti B., Foster C. S. Ascorbic acid therapy in a thermal burn model of corneal ulceration in rabbits. Am J Ophthalmol. 1985 Jan 15;99(1):74–82. doi: 10.1016/s0002-9394(14)75871-4. [DOI] [PubMed] [Google Scholar]
  72. Phillips K., Arffa R., Cintron C., Rose J., Miller D., Kublin C. L., Kenyon K. R. Effects of prednisolone and medroxyprogesterone on corneal wound healing, ulceration, and neovascularization. Arch Ophthalmol. 1983 Apr;101(4):640–643. doi: 10.1001/archopht.1983.01040010640024. [DOI] [PubMed] [Google Scholar]
  73. Pirie A., Werb Z., Burleigh M. C. Collagenase and other proteinases in the cornea of the retinol-deficient rat. Br J Nutr. 1975 Sep;34(2):297–309. doi: 10.1017/s0007114575000347. [DOI] [PubMed] [Google Scholar]
  74. Prause J. U. Immunoelectrophoretic determination of tear fluid proteins collected by the Schirmer I test. Acta Ophthalmol (Copenh) 1979;57(6):959–967. doi: 10.1111/j.1755-3768.1979.tb00526.x. [DOI] [PubMed] [Google Scholar]
  75. Prause J. U., Jensen O. A. PAS-positive polymorphonuclear leucocytes in corneal ulcers. Acta Ophthalmol (Copenh) 1980 Aug;58(4):556–566. doi: 10.1111/j.1755-3768.1980.tb08297.x. [DOI] [PubMed] [Google Scholar]
  76. Prause J. U., Jensen O. A. Studies on human corneal ulcers treated with histoacrylic glue. Morphological studies of a successful and unsuccessful membrane. Acta Ophthalmol (Copenh) 1982 Aug;60(4):547–556. doi: 10.1111/j.1755-3768.1982.tb00599.x. [DOI] [PubMed] [Google Scholar]
  77. Prause J. U. Serum antiproteases and polymorphonuclear leucocyte neutral collagenolytic protease in the tear fluid of patients with corneal ulcers treated with n-butylcyano acrylate glue. Acta Ophthalmol (Copenh) 1983 Apr;61(2):283–291. doi: 10.1111/j.1755-3768.1983.tb01422.x. [DOI] [PubMed] [Google Scholar]
  78. Prause J. U., Sjöström H., Norén O., Josefsson L. A micromodification of the electroimmunoassay. Anal Biochem. 1978 Apr;85(2):564–571. doi: 10.1016/0003-2697(78)90255-5. [DOI] [PubMed] [Google Scholar]
  79. ROBB R. M., KUWABARA T. Corneal wound healing. I. The movement of polymorphonuclear leukocytes into corneal wounds. Arch Ophthalmol. 1962 Nov;68:636–642. doi: 10.1001/archopht.1962.00960030640012. [DOI] [PubMed] [Google Scholar]
  80. Rivkin I., Rosenblatt J., Becker E. L. The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin. J Immunol. 1975 Oct;115(4):1126–1134. [PubMed] [Google Scholar]
  81. Robertson P. B., Ryel R. B., Taylor R. E., Shyu K. W., Fullmer H. M. Collagenase: localization in polymorphonuclear leukocyte granules in the rabbit. Science. 1972 Jul 7;177(4043):64–65. doi: 10.1126/science.177.4043.64. [DOI] [PubMed] [Google Scholar]
  82. Rodrigues M. M., Fine B. S., Laibson P. R., Zimmerman L. E. Disorders of the corneal epithelium. A clinicopathologic study of dot, geographic, and fingerprint patterns. Arch Ophthalmol. 1974 Dec;92(6):475–482. doi: 10.1001/archopht.1974.01010010489005. [DOI] [PubMed] [Google Scholar]
  83. Sendele D. D., Kenyon K. R., Wolf G., Hanninen L. A. Epithelial abrasion precipitates stromal ulceration in the vitamin A--deficient rat cornea. Invest Ophthalmol Vis Sci. 1982 Jul;23(1):64–72. [PubMed] [Google Scholar]
  84. Seng W. L., Glogowski J. A., Wolf G., Berman M. B., Kenyon K. R., Kiorpes T. C. The effect of thermal burns on the release of collagenase from corneas of vitamin A--deficient and controls rats. Invest Ophthalmol Vis Sci. 1980 Dec;19(12):1461–1470. [PubMed] [Google Scholar]
  85. Seng W. L., Kenyon K. R., Wolf G. Studies on the source and release of collagenase in thermally burned corneas of vitamin A-deficient and control rats. Invest Ophthalmol Vis Sci. 1982 Jan;22(1):62–72. [PubMed] [Google Scholar]
  86. Slansky H. H., Dohlman C. H. Collagenase and the cornea. Surv Ophthalmol. 1970 Mar;14(5):402–415. [PubMed] [Google Scholar]
  87. Smolin G., Okumoto M. Vitamin A acid and corneal epithelial wound healing. Ann Ophthalmol. 1981 May;13(5):563–566. [PubMed] [Google Scholar]
  88. Sommer A., Emran N. Topical retinoic acid in the treatment of corneal xerophthalmia. Am J Ophthalmol. 1978 Nov;86(5):615–617. doi: 10.1016/0002-9394(78)90177-0. [DOI] [PubMed] [Google Scholar]
  89. Sommer A., Green W. R., Kenyon K. R. Clinicohistopathologic correlations in xerophthalmic ulceration and necrosis. Arch Ophthalmol. 1982 Jun;100(6):953–963. doi: 10.1001/archopht.1982.01030030961014. [DOI] [PubMed] [Google Scholar]
  90. Srinivasan B. D., Kulkarni P. S. The effect of steroidal and nonsteroidal anti-inflammatory agents on corneal re-epithelialization. Invest Ophthalmol Vis Sci. 1981 May;20(5):688–691. [PubMed] [Google Scholar]
  91. Srinivasan B. D., Kulkarni P. S. The role of arachidonic acid metabolites in the mediation of the polymorphonuclear leukocyte response following corneal injury. Invest Ophthalmol Vis Sci. 1980 Sep;19(9):1087–1093. [PubMed] [Google Scholar]
  92. Tseng S. C., Maumenee A. E., Stark W. J., Maumenee I. H., Jensen A. D., Green W. R., Kenyon K. R. Topical retinoid treatment for various dry-eye disorders. Ophthalmology. 1985 Jun;92(6):717–727. doi: 10.1016/s0161-6420(85)33968-4. [DOI] [PubMed] [Google Scholar]
  93. Ubels J. L., Edelhauser H. F., Austin K. H. Healing of experimental corneal wounds treated with topically applied retinoids. Am J Ophthalmol. 1983 Mar;95(3):353–358. doi: 10.1016/s0002-9394(14)78305-9. [DOI] [PubMed] [Google Scholar]
  94. Van Horn D. L., DeCarlo J. D., Schutten W. H., Hyndiuk R. A. Topical retinoic acid in the treatment of experimental xerophthalmia in the rabbit. Arch Ophthalmol. 1981 Feb;99(2):317–321. doi: 10.1001/archopht.1981.03930010319021. [DOI] [PubMed] [Google Scholar]
  95. Van Horn D. L., Schutten W. H., Hyndiuk R. A., Kurz P. Xerophthalmia in vitamin A-deficient rabbits. Clinical and ultrastructural alterations in the cornea. Invest Ophthalmol Vis Sci. 1980 Sep;19(9):1067–1079. [PubMed] [Google Scholar]
  96. Wagoner M. D., Kenyon K. R., Gipson I. K., Hanninen L. A., Seng W. L. Polymorphonuclear neutrophils delay corneal epithelial wound healing in vitro. Invest Ophthalmol Vis Sci. 1984 Oct;25(10):1217–1220. [PubMed] [Google Scholar]
  97. Wahl L. M., Olsen C. E., Sandberg A. L., Mergenhagen S. E. Prostaglandin regulation of macrophage collagenase production. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4955–4958. doi: 10.1073/pnas.74.11.4955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Walker D. G., Lapiere C. M., Gross J. A collagenolytic factor in rat bone promoted by parathyroid extract. Biochem Biophys Res Commun. 1964 Apr 22;15(5):397–402. doi: 10.1016/0006-291x(64)90474-7. [DOI] [PubMed] [Google Scholar]
  99. Werb Z., Aggeler J. Proteases induce secretion of collagenase and plasminogen activator by fibroblasts. Proc Natl Acad Sci U S A. 1978 Apr;75(4):1839–1843. doi: 10.1073/pnas.75.4.1839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Zauberman H., Refojo M. F. Keratoplasty with glued-on lenses for alkali burns. An experimental study. Arch Ophthalmol. 1973 Jan;89(1):46–48. doi: 10.1001/archopht.1973.01000040048011. [DOI] [PubMed] [Google Scholar]

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