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. 1987 Feb;146(2):195–199.

A Program to Provide Hepatitis B Immunoprophylaxis to Infants Born to HBsAg-Positive Asian and Pacific Island Women

Karl C Klontz
PMCID: PMC1307238  PMID: 3825119

Abstract

Between January 1, 1984, and December 31, 1985, there were 545 women from Asia and the Pacific Islands who gave birth to a total of 572 infants at Highland General Hospital in Oakland, California (accounting for 20% of all deliveries at that hospital). For countries having more than ten women giving birth during the study period, the percentage of women screened prenatally for HBs antigen (Ag) ranged from a high of 100% (Laos) to a low of 54% (Philippines). HBsAg-positivity rates ranged from a high of 21% (Tonga) to a low of 0% (India). A total of 52 infants was born to 49 HBsAg-positive mothers, and 40 (77%) of the infants received hepatitis B immune globulin (HBIG) within 12 hours of birth. While 80% of the infants received HBIG and at least one dose of hepatitis B vaccine, only 35% received the recommended schedule of HBIG and three doses of vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beasley R. P., Hwang L. Y., Lee G. C., Lan C. C., Roan C. H., Huang F. Y., Chen C. L. Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet. 1983 Nov 12;2(8359):1099–1102. doi: 10.1016/s0140-6736(83)90624-4. [DOI] [PubMed] [Google Scholar]
  2. Beasley R. P., Hwang L. Y., Lin C. C., Chien C. S. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet. 1981 Nov 21;2(8256):1129–1133. doi: 10.1016/s0140-6736(81)90585-7. [DOI] [PubMed] [Google Scholar]
  3. Beasley R. P., Hwang L. Y., Lin C. C., Stevens C. E., Wang K. Y., Sun T. S., Hsieh F. J., Szmuness W. Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial. Lancet. 1981 Aug 22;2(8243):388–393. doi: 10.1016/s0140-6736(81)90832-1. [DOI] [PubMed] [Google Scholar]
  4. Stevens C. E., Beasley R. P., Tsui J., Lee W. C. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med. 1975 Apr 10;292(15):771–774. doi: 10.1056/NEJM197504102921503. [DOI] [PubMed] [Google Scholar]
  5. Stevens C. E., Toy P. T., Tong M. J., Taylor P. E., Vyas G. N., Nair P. V., Gudavalli M., Krugman S. Perinatal hepatitis B virus transmission in the United States. Prevention by passive-active immunization. JAMA. 1985 Mar 22;253(12):1740–1745. [PubMed] [Google Scholar]
  6. Wong V. C., Ip H. M., Reesink H. W., Lelie P. N., Reerink-Brongers E. E., Yeung C. Y., Ma H. K. Prevention of the HBsAg carrier state in newborn infants of mothers who are chronic carriers of HBsAg and HBeAg by administration of hepatitis-B vaccine and hepatitis-B immunoglobulin. Double-blind randomised placebo-controlled study. Lancet. 1984 Apr 28;1(8383):921–926. doi: 10.1016/s0140-6736(84)92388-2. [DOI] [PubMed] [Google Scholar]

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