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. 1976 Jun;258(2):269–278. doi: 10.1113/jphysiol.1976.sp011419

Rectification in the smooth muscle cell membrane of rabbit aorta.

F Mekata
PMCID: PMC1308975  PMID: 957157

Abstract

1. The current-voltage relation of the smooth muscle cell membrane of rabbit aorta was determined by the partition method. 2. No anomalous rectification was observed in any of the following solutions: normal Krebs, Na free choline, Na sulphate, and high K-Na free sulphate. 3. Delayed rectification was seen on application of depolarizing current in both normal Krebs solution and Na free choline solution. 4. High concentration of K made the steady-state current-voltage relation almost linear in a voltage range of about 0 to -20mV. This effect, and steady-state cathodal rectification which was seen in physiological solution, could be explained qualitatively by constant field theory without involving channels capable of anomalous rectification. 5. A slow decrease in K conductance, during application of large and long-lasting hyperpolarizing currents, which occurs in skeletal muscle and is attributed to the tubule system, was never observed in the arteries either in Krebs, Na-free choline, or Na sulphate solution.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian R. H., Freygang W. H. The potassium and chloride conductance of frog muscle membrane. J Physiol. 1962 Aug;163(1):61–103. doi: 10.1113/jphysiol.1962.sp006959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cole K. S., Curtis H. J. MEMBRANE POTENTIAL OF THE SQUID GIANT AXON DURING CURRENT FLOW. J Gen Physiol. 1941 Mar 20;24(4):551–563. doi: 10.1085/jgp.24.4.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Goldman D. E. POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES. J Gen Physiol. 1943 Sep 20;27(1):37–60. doi: 10.1085/jgp.27.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HALL A. E., HUTTER O. F., NOBLE D. Current-voltage relations of Purkinje fibres in sodium-deficient solutions. J Physiol. 1963 Apr;166:225–240. doi: 10.1113/jphysiol.1963.sp007102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HODGKIN A. L., HUXLEY A. F., KATZ B. Measurement of current-voltage relations in the membrane of the giant axon of Loligo. J Physiol. 1952 Apr;116(4):424–448. doi: 10.1113/jphysiol.1952.sp004716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Howell J. N. A lesion of the transverse tubules of skeletal muscle. J Physiol. 1969 May;201(3):515–533. doi: 10.1113/jphysiol.1969.sp008770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Keatinge W. R. Ca concentration and flux in Ca-deprived arteries. J Physiol. 1972 Jul;224(1):35–59. doi: 10.1113/jphysiol.1972.sp009880. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kuriyama H., Mekata F. Biophysical properties of the longitudinal smooth muscle of the guinea-pig rectum. J Physiol. 1971 Feb;212(3):667–683. doi: 10.1113/jphysiol.1971.sp009349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McAllister R. E., Noble D. The effect of subthreshold potentials on the membrane current in cardiac Purkinje fibres. J Physiol. 1967 May;190(2):381–387. doi: 10.1113/jphysiol.1967.sp008216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mekata F. Current spread in the smooth muscle of the rabbit aorta. J Physiol. 1974 Oct;242(1):143–155. doi: 10.1113/jphysiol.1974.sp010698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mekata F. Electrophysiological studies of the smooth muscle cell membrane of the rabbit common carotid artery. J Gen Physiol. 1971 Jun;57(6):738–751. doi: 10.1085/jgp.57.6.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mobley B. A., Page E. The surface area of sheep cardiac Purkinje fibres. J Physiol. 1972 Feb;220(3):547–563. doi: 10.1113/jphysiol.1972.sp009722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Noble D., Stein R. B. The threshold conditions for initiation of action potentials by excitable cells. J Physiol. 1966 Nov;187(1):129–162. doi: 10.1113/jphysiol.1966.sp008079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Noble D., Tsien R. W. The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. J Physiol. 1968 Mar;195(1):185–214. doi: 10.1113/jphysiol.1968.sp008454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Page E., Power B., Fozzard H. A., Meddoff D. A. Sarcolemmal evaginations with knob-like or stalked projections in Purkinje fibers of the sheep's heart. J Ultrastruct Res. 1969 Aug;28(3):288–300. doi: 10.1016/s0022-5320(69)90086-0. [DOI] [PubMed] [Google Scholar]
  16. Somlyo A. P., Devine C. E., Somlyo A. V., North S. R. Sarcoplasmic reticulum and the temperature-dependent contraction of smooth muscle in calcium-free solutions. J Cell Biol. 1971 Dec;51(3):722–741. doi: 10.1083/jcb.51.3.722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stefani E., Steinbach A. B. Resting potential and electrical properties of frog slow muscle fibres. Effect of different external solutions. J Physiol. 1969 Aug;203(2):383–401. doi: 10.1113/jphysiol.1969.sp008869. [DOI] [PMC free article] [PubMed] [Google Scholar]

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