Abstract
Absorption and secretion from a mixture of seventeen free amino acids has been measured in isolated perfused rat small intestine. 2. The absorption rate of an amino acid from this mixture is proportional to its concentration in the perfusate and independent of its chemical constitution. The constant of proportionality is the same as that previously observed when the perfusate contained peptides as well as amino acids. 3. Amino acids are concentrated, on average, sixfold during passage across the mucosa, and the free amino acid composition of the secretion into the tissue fluid is very similar to that of the luminal perfusate. 4. Peptides do not appear to be added to the tissue fluid during absorption of free amino acids. 5. It is concluded that the mechanisms for absorption of free amino acids are in general independent of those for absorption of peptides.
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Selected References
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- Adibi S. A., Gray S. J. Intestinal absorption of essential amino acids in man. Gastroenterology. 1967 May;52(5):837–845. [PubMed] [Google Scholar]
- Asatoor A. M., Cheng B., Edwards K. D., Lant A. F., Matthews D. M., Milne M. D., Navab F., Richards A. J. Intestinal absorption of two dipeptides in Hartnup disease. Gut. 1970 May;11(5):380–387. doi: 10.1136/gut.11.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bronk J. R., Leese H. J. The absorption of a mixture of amino acids by rat small intestine. J Physiol. 1974 Aug;241(1):271–286. doi: 10.1113/jphysiol.1974.sp010653. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craft I. L., Geddes D., Hyde C. W., Wise I. J., Matthews D. M. Absorption and malabsorption of glycine and glycine peptides in man. Gut. 1968 Aug;9(4):425–437. doi: 10.1136/gut.9.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fisher R. B., Gardner M. L. A kinetic approach to the study of absorption of solutes by isolated perfused small intestine. J Physiol. 1974 Aug;241(1):211–234. doi: 10.1113/jphysiol.1974.sp010650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gardner M. L. Absorption of amino acids and peptides from a complex mixture in the isolated small intestine of the rat. J Physiol. 1975 Dec;253(1):233–256. doi: 10.1113/jphysiol.1975.sp011189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perry T. L., Hansen S. Technical pitfalls leading to errors in the quantitation of plasma amino acids. Clin Chim Acta. 1969 Jul;25(1):53–58. doi: 10.1016/0009-8981(69)90226-5. [DOI] [PubMed] [Google Scholar]