Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1976 Mar;255(3):687–700. doi: 10.1113/jphysiol.1976.sp011303

Haemodynamic responses and renin release during stimulation of afferent renal nerves in the cat.

F R Calaresu, A Stella, A Zanchetti
PMCID: PMC1309274  PMID: 1263140

Abstract

1. Experiments were done on anaesthetized cats to study the effect of electrical stimulation of afferent renal nerves on the circulatory system and on the release of renin from the kidney. 2. Stimulation of afferent renal nerves over a wide range of parameters consistently elicited an increase in arterial pressure and heart rate. This response was still present in paralysed animals and was not accompanied by changes in respiration or in sympathetic autonomic activity usually associated with painful stimulation. Mesenteric and iliac vasoconstriction was observed concomitantly with the increase in arterial pressure. 3. Release of renin from the contralateral innervated kidney was not significantly changed by stimulation of afferent renal nerves. 4. The existence of renal vascular mechanoreceptors was investigated by altering renal circulation. Stenosis of the renal artery or a marked reduction in renal perfusion pressure elicited an increase in arterial pressure while stenosis of the renal vein elicited a decrease in arterial pressure. These responses, however, were not affected by denervation of the kidney and were therefore interpreted as not being due to neural mechanisms. 5. The precise nature, location and physiological role of renal receptors involved in the cardiovascular responses observed during electrical stimulation of afferent renal nerves remain to be determined.

Full text

PDF
691

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aars H., Akre S. Reflex changes in sympathetic activity and arterial blood pressure evoked by afferent stimulation of the renal nerve. Acta Physiol Scand. 1970 Feb;78(2):184–188. doi: 10.1111/j.1748-1716.1970.tb04654.x. [DOI] [PubMed] [Google Scholar]
  2. Aström A., Crafoord J. Afferent activity recorded in the kidney nerves of rats. Acta Physiol Scand. 1967 May;70(1):10–15. doi: 10.1111/j.1748-1716.1967.tb03595.x. [DOI] [PubMed] [Google Scholar]
  3. Aström A., Crafoord J. Afferent and efferent activity in the renal nerves of cats. Acta Physiol Scand. 1968 Sep-Oct;74(1):69–78. doi: 10.1111/j.1748-1716.1968.tb04215.x. [DOI] [PubMed] [Google Scholar]
  4. Beacham W. S., Kunze D. L. Renal receptors evoking a spinal vasometer reflex. J Physiol. 1969 Mar;201(1):73–85. doi: 10.1113/jphysiol.1969.sp008743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cafiero F., Calaresu F. R., Stella A., Zanchetti A. Proceedings: Cardiovascular responses and renin release during stimulation of afferent renal nerves in the cat. J Physiol. 1975 Jul;249(1):46P–47P. [PubMed] [Google Scholar]
  6. Calaresu F. R., Mogenson G. J. Cardiovascular responses to electrical stimulation of the septum in the rat. Am J Physiol. 1972 Oct;223(4):777–782. doi: 10.1152/ajplegacy.1972.223.4.777. [DOI] [PubMed] [Google Scholar]
  7. Niijima A. The effect of efferent discharges in renal nerves on the activity of arterial mechanoreceptors in the kidney in rabbit. J Physiol. 1972 Apr;222(2):335–343. doi: 10.1113/jphysiol.1972.sp009800. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nijima A. Afferent discharges from arterial mechanoreceptors in the kidney of the rabbit. J Physiol. 1971 Dec;219(2):477–485. doi: 10.1113/jphysiol.1971.sp009673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Richardson D., Stella A., Leonetti G., Bartorelli A., Zanchetti A. Mechanisms of renal release of renin by electrical stimulation of the brainstem in the cat. Circ Res. 1974 Apr;34(4):425–434. doi: 10.1161/01.res.34.4.425. [DOI] [PubMed] [Google Scholar]
  10. Uchida Y., Kamisaka K., Ueda H. Two types of renal mechanoreceptors. Jpn Heart J. 1971 May;12(3):233–241. doi: 10.1536/ihj.12.233. [DOI] [PubMed] [Google Scholar]
  11. Ueda H., Uchida Y., Kamisaka K. Mechanism of the reflex depressor effect by the kidney in dog. Jpn Heart J. 1967 Nov;8(6):597–606. doi: 10.1536/ihj.8.597. [DOI] [PubMed] [Google Scholar]
  12. Woodworth R. S., Sherrington C. S. A pseudaffective reflex and its spinal path. J Physiol. 1904 Jun 30;31(3-4):234–243. doi: 10.1113/jphysiol.1904.sp001034. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES