Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1976 Jun;257(3):673–686. doi: 10.1113/jphysiol.1976.sp011391

Effects of various ambient temperatures and of heating and cooling the hypothalamus and cervical spinal cord on antidiuretic hormone secretion and urinary osmolality in pigs.

M L Forsling, D L Ingram, M W Stanier
PMCID: PMC1309385  PMID: 950609

Abstract

1. Plasma ADH concentration, urinary and plasma osmolality and haematocrit were measured in young pigs placed in cold, thermoneutral, warm and hot ambient temperatures. In some experiments a thermode placed in the hypothalamus or over the cervical spinal cord was heated or cooled at various ambient temperatures. 2. Plasma ADH concentration remained at a low level (0-5--5 muu. ml.-1) over 2 hr or 3 hr periods when the pigs were in cold, thermoneutral or warm ambient temperatures. A hot environment, which caused a marked rise in the pigs' rectal temperature, was associated with a large rise in plasma ADH level. 3. The rise in plasma ADH level which occurred during an increase in body temperature was consistently and completely suppressed by simultaneous cooling of the thermode in the pre-optic region to 5 to 10 degrees C. When the thermode was in the region of the supraoptic nucleus the rise in ADH was only partly suppressed, and when it was over the cervical cord it was only sometimes suppressed. 4. Cooling the thermodes in any position at a cold or thermoneutral ambient temperature, or heating them at a thermoneutral or warm ambient temperature, caused no consistent change in ADH. 5. A diuresis, with a urinary flow-rate of at most 1 ml. min-1 and minimal urinary osmolality of 53 m-osmole kg-1, was observed on only three occasions, twice during cooling of a thermode in the hypothalamus and once after the end of a period when the thermode was heated. In each case, the plasma ADH was less than 2 muu. ml.-1. 6. A slight rise of haematocrit in cold ambient conditions and a slight fall in the warm were observed. Otherwise changes in haematocrit were trivial, and a shift of water between vascular system and interstitium could not be invoked to account for changes in ADH levels. Observed variation of plasma osmolality was also slight.

Full text

PDF
676

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BADER R. A., ELIOT J. W., BASS D. E. Hormonal and renal mechanisms of cold diuresis. J Appl Physiol. 1952 Feb;4(8):649–658. doi: 10.1152/jappl.1952.4.8.649. [DOI] [PubMed] [Google Scholar]
  2. BARATZ R. A., INGRAHAM R. C. Renal hemodynamics and antidiuretic hormone release associated with volume regulation. Am J Physiol. 1960 Mar;198:565–570. doi: 10.1152/ajplegacy.1960.198.3.565. [DOI] [PubMed] [Google Scholar]
  3. Baldwin B. A., Ingram D. L. Effect of heating & cooling the hypothalamus on behavioral thermoregulation in the pig. J Physiol. 1967 Jul;191(2):375–392. doi: 10.1113/jphysiol.1967.sp008256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dunn F. L., Brennan T. J., Nelson A. E., Robertson G. L. The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest. 1973 Dec;52(12):3212–3219. doi: 10.1172/JCI107521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fabian M., Forsling M. L., Jones J. J., Lee J. The release, clearance and plasma protein binding of oxytocin in the anaesthetized rat. J Endocrinol. 1969 Feb;43(2):175–189. doi: 10.1677/joe.0.0430175. [DOI] [PubMed] [Google Scholar]
  6. Forsling M. L., Ingram D. L., Stanier M. W. Effect of changes in hypothalamic temperature on ADH secretion in pigs. J Physiol. 1975 May;247(1):49P–50P. [PubMed] [Google Scholar]
  7. Forsling M. L., Jones J. J., Lee J. Factors influencing the sensitivity of the rat to vasopressin. J Physiol. 1968 May;196(2):495–505. doi: 10.1113/jphysiol.1968.sp008520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Forsling M. L. Proceedings: Extraction of neurohypophysial hormones for bioassay. J Physiol. 1974 Aug;241(1):3P–5P. [PubMed] [Google Scholar]
  9. Hayward J. N., Baker M. A. Diuretic and thermoregulatory responses to preoptic cooling in the monkey. Am J Physiol. 1968 Apr;214(4):843–850. doi: 10.1152/ajplegacy.1968.214.4.843. [DOI] [PubMed] [Google Scholar]
  10. ITOH S. The release of antidiuretic hormone from the posterior pituitary body on exposure to heat. Jpn J Physiol. 1954 Sep 1;4(3):185–190. doi: 10.2170/jjphysiol.4.185. [DOI] [PubMed] [Google Scholar]
  11. Ingram D. L., Legge K. F. The influence of deep body temperatures and skin temperatures on peripheral blood flow in the pig. J Physiol. 1971 Jul;215(3):693–707. doi: 10.1113/jphysiol.1971.sp009492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Johnson J. A., Moore W. W., Segar W. E. Small changes in left atrial pressure and plasma antidiuretic hormone titers in dogs. Am J Physiol. 1969 Jul;217(1):210–214. doi: 10.1152/ajplegacy.1969.217.1.210. [DOI] [PubMed] [Google Scholar]
  13. PABST K., THRON H. L. [Cold diuresis in the non-anesthetized dog]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;270:585–606. [PubMed] [Google Scholar]
  14. RODBARD S., SAIKI H., MALIN A., YOUNG C. Significance of changes in plasma and extracellular volumes in induced hyperthermia and hypothermia. Am J Physiol. 1951 Nov;167(2):485–498. doi: 10.1152/ajplegacy.1951.167.2.485. [DOI] [PubMed] [Google Scholar]
  15. SHARE L. EFFECTS OF CAROTID OCCLUSION AND LEFT ATRIAL DISTENTION ON PLASMA VASOPRESSIN TITER. Am J Physiol. 1965 Feb;208:219–223. doi: 10.1152/ajplegacy.1965.208.2.219. [DOI] [PubMed] [Google Scholar]
  16. Segar W. E., Moore W. W. The regulation of antidiuretic hormone release in man: I. Effects of change in position and ambient temperature on blood ADH levels. J Clin Invest. 1968 Sep;47(9):2143–2151. doi: 10.1172/JCI105900. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Szczepanska-Sadowska E. Plasma ADH increase and thirst suppression elicited by preoptic heating in the dog. Am J Physiol. 1974 Jan;226(1):155–161. doi: 10.1152/ajplegacy.1974.226.1.155. [DOI] [PubMed] [Google Scholar]
  18. Wyndham C. H., Benade A. J., Williams C. G., Strydom N. B., Goldin A., Heyns A. J. Changes in central circulation and body fluid spaces during acclimatization to heat. J Appl Physiol. 1968 Nov;25(5):586–593. doi: 10.1152/jappl.1968.25.5.586. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES