Abstract
1. The direction of torsion produced during active shortening of helical strips of sheep carotid arteries was measured to assess whether inner or outer muscle was contracting. 2. Noradrenaline contracted inner (non-innervated) muscle in lower concentrations than were needed to contract outer (innervated) muscle, even with desipramine present to prevent uptake of noradrenaline by the nerves and with enough cyanide present to rise the normally low O2 tension of inner muscle to that of outer muscle. 3. Activation of sympathetic nerves in the outer part of the artery by nicotine caused almost evenly balanced contraction of both parts of the wall, with slight bias to outer contraction. 4. Moderate external constriction of the artery in vivo for 10-17 days, in order to raise pressure throughout the wall to intraluminal pressure, made the entire wall nerve-free. 5. The results provide evidence that the nerves can induce substantial activation of inner muscle, which is highly sensitive to noradrenaline, and that the absence of nerves from inner muscle can be explained by the high pressure there.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bevan J. A., Osher J. V. Distribution of norepinephrine released from adrenergic motor terminals in arterial wall. Eur J Pharmacol. 1970;13(1):55–58. doi: 10.1016/0014-2999(70)90182-2. [DOI] [PubMed] [Google Scholar]
- Bevan J. A., Purdy R. E. Variations in adrenergic innervation and contractile responses of the rabbit saphenous artery. Circ Res. 1973 Jun;32(6):746–751. doi: 10.1161/01.res.32.6.746. [DOI] [PubMed] [Google Scholar]
- Danta G., Fowler T. J., Gilliatt R. W. Conduction block after a pneumatic tourniquet. J Physiol. 1971 May;215(1):50P–52P. [PubMed] [Google Scholar]
- FOLKOW B., OBERG B., RUBINSTEIN E. H. A PROPOSED DIFFERENTIATED NEURO-EFFECTOR ORGANIZATION IN MUSCLE RESISTANCE VESSELS. Angiologica. 1964;1:197–208. doi: 10.1159/000157582. [DOI] [PubMed] [Google Scholar]
- Gillespie J. S., Rae R. M. Constrictor and compliance responses of some arteries to nerve or drug stimulation. J Physiol. 1972 May;223(1):109–130. doi: 10.1113/jphysiol.1972.sp009837. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Graham J. M., Keatinge W. R. Differences in sensitivity to vasoconstrictor drugs within the wall of the sheep carotid artery. J Physiol. 1972 Mar;221(2):477–492. doi: 10.1113/jphysiol.1972.sp009763. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keatinge W. R. Electrical and mechanical response of arteries to stimulation of sympathetic nerves. J Physiol. 1966 Aug;185(3):701–715. doi: 10.1113/jphysiol.1966.sp008011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mori K., Ogushi N., Ikeda M., Yamamoto K., Tsunekawa K. Histochemical demonstration of adrenergic fibers in the smooth muscle layer of media of arteries supplying abdominal organs. Nihon Geka Hokan. 1969 Mar 1;38(2):236–248. [PubMed] [Google Scholar]
- Niinikoski J., Heughan C., Hunt T. K. Oxygen tensions in the aortic wall of normal rabbits. Atherosclerosis. 1973 May-Jun;17(3):353–359. doi: 10.1016/0021-9150(73)90026-9. [DOI] [PubMed] [Google Scholar]
- Ochoa J., Fowler T. J., Gilliatt R. W. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972 Dec;113(Pt 3):433–455. [PMC free article] [PubMed] [Google Scholar]