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Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1974 Oct;38(4):398–405.

Lesions of the Central Nervous System Induced in Nonhuman Primates by Live Influenza Viruses

G Lussier 1, A Boudreault 1, V Pavilanis 1, E DiFranco 1
PMCID: PMC1319841  PMID: 4279758

Abstract

Intracerebral and intraspinal inoculations of non-neuropathic and neuropathic strains of influenza virus into rhesus, patas and cercopithecus monkeys resulted in an acute focal ependymitis, choroiditis and meningitis followed by focal ependymal denuding without parenchymal involvement. Aqueductal stenosis and moderate hydrocephalus developed in two animals as sequelae of ependymal cell loss.

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Selected References

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  1. Beare A. S., Bynoe M. L. Attenuation of human influenza A viruses. Br Med J. 1969 Oct 25;4(5677):198–201. doi: 10.1136/bmj.4.5677.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bell T. M., Narang H. K., Field E. J. Influenzal encephalitis in mice. A histopathological and electron microscopical study. Arch Gesamte Virusforsch. 1971;34(2):157–167. doi: 10.1007/BF01241717. [DOI] [PubMed] [Google Scholar]
  3. CAIRNS H. J. F. Intracerebral inoculation of mice; fate of the inoculum. Nature. 1950 Nov 25;166(4230):910–911. doi: 10.1038/166910b0. [DOI] [PubMed] [Google Scholar]
  4. Dohrmann G. J. The choroid plexus: a historical review. Brain Res. 1970 Mar 3;18(2):197–218. doi: 10.1016/0006-8993(70)90324-0. [DOI] [PubMed] [Google Scholar]
  5. FRASER K. B., NAIRN R. C., McENTEGART M. G., CHADWICK C. S. Neurotropic and non-neurotropic influenza-A infection of mouse brain studied with fluorescent antibody. J Pathol Bacteriol. 1959 Oct;78:423–433. doi: 10.1002/path.1700780209. [DOI] [PubMed] [Google Scholar]
  6. Johnson K. P., Johnson R. T. Granular ependymitis. Occurrence in myxovirus infected rodents and prevalence in man. Am J Pathol. 1972 Jun;67(3):511–526. [PMC free article] [PubMed] [Google Scholar]
  7. Johnson R. T., Johnson K. P. Hydrocephalus as a sequela of experimental myxovirus infections. Exp Mol Pathol. 1969 Feb;10(1):68–80. doi: 10.1016/0014-4800(69)90049-5. [DOI] [PubMed] [Google Scholar]
  8. MIMS C. A. An analysis of the toxicity for mice of influenza virus. I. Intracerebral toxicity. Br J Exp Pathol. 1960 Dec;41:586–592. [PMC free article] [PubMed] [Google Scholar]
  9. MIMS C. A. Intracerebral injections and the growth of viruses in the mouse brain. Br J Exp Pathol. 1960 Feb;41:52–59. [PMC free article] [PubMed] [Google Scholar]
  10. Miyoshi K., Gamboa E. T., Harter D. H., Wolf A., Hsu K. C. Influenza virus encephalitis in squirrel monkeys receiving immunosuppressive therapy. J Immunol. 1971 Apr;106(4):1119–1121. [PubMed] [Google Scholar]
  11. Miyoshi K., Wolf A., Harter D. H., Duffy P. E., Gamboa E. T., Hsu K. C. Murine influenza virus encephalomyelitis. I. Neuropathological and immunofluorescence findings. J Neuropathol Exp Neurol. 1973 Jan;32(1):51–71. doi: 10.1097/00005072-197301000-00004. [DOI] [PubMed] [Google Scholar]
  12. Narayan O. Pathogenesis of lethal influenza virus infection in turkeys. II. Central nervous system phase of infection. J Comp Pathol. 1972 Apr;82(2):139–146. doi: 10.1016/0021-9975(72)90055-2. [DOI] [PubMed] [Google Scholar]
  13. Rosenberg G. A. Meningoencephalitis following an influenza vaccination. N Engl J Med. 1970 Nov 26;283(22):1209–1209. doi: 10.1056/nejm197011262832208. [DOI] [PubMed] [Google Scholar]
  14. WARREN W. R. Encephalopathy due to influenza vaccine. AMA Arch Intern Med. 1956 Jun;97(6):803–805. doi: 10.1001/archinte.1956.00250240155017. [DOI] [PubMed] [Google Scholar]
  15. WOODS C. A., ELLISON G. W. ENCEPHALOPATHY FOLLOWING INFLUENZA IMMUNIZATION. J Pediatr. 1964 Nov;65:745–748. doi: 10.1016/s0022-3476(64)80160-8. [DOI] [PubMed] [Google Scholar]
  16. Yahr M. D., Lobo-Antunes J. Relapsing encephalomyelitis following the use of influenza vaccine. Arch Neurol. 1972 Aug;27(2):182–183. doi: 10.1001/archneur.1972.00490140086012. [DOI] [PubMed] [Google Scholar]

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