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. 1982 Jul;46(3):287–292.

Aerosol vaccination of calves with pasteurella haemolytica against experimental respiratory disease.

K W Jericho, E V Langford
PMCID: PMC1320326  PMID: 6290014

Abstract

Three experiments were conducted on calves in which the efficacy of vaccination with live Pasteurella haemolytica in aerosol was tested by challenge with sequential aerosol exposure to bovine herpesvirus 1 and P. haemolytica. Neither single nor multiple aerosol vaccinations protected against the experimental disease. Macroscopically recognizable rhinitis, tonsillitis, tracheitis and pneumonia occurred in both controls and vaccinates. In one experiment as many as three aerosol vaccinations with live P. haemolytica for up to 20 minutes failed to elicit clinical signs in exposed calves. Pasteurella haemolytica was isolated less frequently from tissues of vaccinated calves than from those of nonvaccinated calves. Pasteurella haemolytica was isolated from deep nasal swabs of 4/14 vaccinated calves five and six days after viral exposure. It was concluded that although bovine herpesvirus 1 vaccination has been shown previously to prevent the experimental disease produced by bovine herpesvirus 1-P. haemolytica, live P. haemolytica vaccination by aerosol will not provide the same protection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carter G. R. The Preparation and Use of Vaccines for the Prevention of Pasteurellosis. Can Vet J. 1961 Mar;2(3):96–98. [PMC free article] [PubMed] [Google Scholar]
  2. Cho H. J. Demonstration of Complement Fixing Antibody in the Sera of Cattle Vaccinated with Combined Living Blackleg-anthrax Vaccine. Can J Comp Med. 1971 Apr;35(2):155–160. [PMC free article] [PubMed] [Google Scholar]
  3. Duncan J. R., Thomson R. G. Influence of immunization procedures on upper respiratory tract immunity in cattle. Can J Comp Med. 1970 Jan;34(1):94–100. [PMC free article] [PubMed] [Google Scholar]
  4. Friend S. C., Wilkie B. N., Thomson R. G., Barnum D. A. Bovine pneumonic pasteurellosis: experimental induction in vaccinated and nonvaccinated calves. Can J Comp Med. 1977 Jan;41(1):77–83. [PMC free article] [PubMed] [Google Scholar]
  5. GALE C., HAMDY A. H., TRAPP A. L. Studies on an experimental vaccine for prophylaxis of shipping fever. J Am Vet Med Assoc. 1963 Apr 15;142:884–887. [PubMed] [Google Scholar]
  6. Gilmour N. J., Martin W. B., Sharp J. M., Thompson D. A., Wells P. W. The development of vaccines against pneumonic pasteurellosis in sheep. Vet Rec. 1979 Jan 6;104(1):15–15. doi: 10.1136/vr.104.1.15. [DOI] [PubMed] [Google Scholar]
  7. Hand W. L., Cantey J. R. Antibacterial mechanisms of the lower respiratory tract. I. Immunoglobulin synthesis and secretion. J Clin Invest. 1974 Feb;53(2):354–362. doi: 10.1172/JCI107567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jakab G. J. Factors influencing the immune enhancement of intrapulmonary bactericidal mechanisms. Infect Immun. 1976 Aug;14(2):389–398. doi: 10.1128/iai.14.2.389-398.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jericho K. W., Darcel C. Q. Response of the respiratory tract of calves kept at controlled climatic conditions to bovine Herpesvirus 1 in aerosol. Can J Comp Med. 1978 Apr;42(2):156–167. [PMC free article] [PubMed] [Google Scholar]
  10. Jericho K. W., Langford E. V. Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica. Can J Comp Med. 1978 Jul;42(3):269–277. [PMC free article] [PubMed] [Google Scholar]
  11. Jericho K. W., Magwood S. E. Histological features of respiratory epithelium of calves held at differing temperature and humidity. Can J Comp Med. 1977 Oct;41(4):369–379. [PMC free article] [PubMed] [Google Scholar]
  12. Jericho K. W., Magwood S. E., Stockdale P. H. Letter to the editor: Prevention of experimental bovine pneumonic pasteurellosis by exposure to IBR virus. Can Vet J. 1976 Jul;17(7):194–195. [PMC free article] [PubMed] [Google Scholar]
  13. Kaltreider H. B., Turner F. N. Appearance of antibody-forming cells in lymphocytes from the lower respiratory tract of the dog after intrapulmonary or intravenous immunization with sheep erythrocytes. Am Rev Respir Dis. 1976 May;113(5):613–617. doi: 10.1164/arrd.1976.113.5.613. [DOI] [PubMed] [Google Scholar]
  14. PALOTAY J. L., YOUNG S., LOVELACE S. A., NEWHALL J. H. BOVINE RESPIRATORY INFECTIONS. II. FIELD TRIAL USING BACTERIAL VACCINE PRODUCTS AS A MEANS OF PROPHYLAXIS. Am J Vet Res. 1963 Nov;24:1137–1142. [PubMed] [Google Scholar]
  15. Stockdale P. H., Jericho K. W., Yates W. D., Darcel C., Langford E. V. Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention. Can J Comp Med. 1979 Jul;43(3):272–279. [PMC free article] [PubMed] [Google Scholar]
  16. Walker R. D., Corstvet R. E., Panciera R. J. Study of bovine pulmonary response to Pasteurella haemolytica: pulmonary macrophage response. Am J Vet Res. 1980 Jul;41(7):1008–1014. [PubMed] [Google Scholar]
  17. Woods G. T., Mansfield M. E., Cmarik G. F., Marquis G. A four-year clinical and serologic study of the use of inactivated parainfluenza-3 virus vaccines and Pasteurella sp. bacterins in beef calves. Vet Med Small Anim Clin. 1974 Apr;69(4):474–passim. [PubMed] [Google Scholar]

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