Abstract
It is often desirable to characterize membrane current fluctuations from ionic channels under conditions in which the mean current and the variance of the fluctuations change with time. A simple theory is developed that relates the power spectrum to the channel characteristics under such nonstationary conditions, assuming that the mean current time-course has been removed from the fluctuation records. Strategies for removing the mean time-course are discussed, the spectra are calculated from simulated channel fluctuations for comparison with the theory.
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Selected References
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