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. 1981 Sep;35(3):771–781. doi: 10.1016/S0006-3495(81)84826-6

Mechanics of Rouleau formation.

R Skalak, P R Zarda, K M Jan, S Chien
PMCID: PMC1327562  PMID: 7272459

Abstract

The formation of rouleau of red blood cells is considered from the standpoint of adhesion theory. With the use of the elastic properties of the red blood cell membrane obtained from previous work, the strain energy of the red blood cell in rouleau formation has been computed. The surface energy of adhesion for the bonding of two red blood cells is then computed from the variation of this strain energy. Computed cell shapes agree well with experiments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chien S. Electrochemical interactions between erythrocyte surfaces. Thromb Res. 1976 May;8(2 Suppl):189–202. doi: 10.1016/0049-3848(76)90062-1. [DOI] [PubMed] [Google Scholar]
  2. Chien S., Jan K. Ultrastructural basis of the mechanism of rouleaux formation. Microvasc Res. 1973 Mar;5(2):155–166. doi: 10.1016/0026-2862(73)90068-x. [DOI] [PubMed] [Google Scholar]
  3. Evans E. A. Minimum energy analysis of membrane deformation applied to pipet aspiration and surface adhesion of red blood cells. Biophys J. 1980 May;30(2):265–284. doi: 10.1016/S0006-3495(80)85093-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Evans E., Fung Y. C. Improved measurements of the erythrocyte geometry. Microvasc Res. 1972 Oct;4(4):335–347. doi: 10.1016/0026-2862(72)90069-6. [DOI] [PubMed] [Google Scholar]
  5. Jan K. M., Chien S. Influence of the ionic composition of fluid medium on red cell aggregation. J Gen Physiol. 1973 May;61(5):655–668. doi: 10.1085/jgp.61.5.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jan K. M., Chien S. Role of surface electric charge in red blood cell interactions. J Gen Physiol. 1973 May;61(5):638–654. doi: 10.1085/jgp.61.5.638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Skalak R., Tozeren A., Zarda R. P., Chien S. Strain energy function of red blood cell membranes. Biophys J. 1973 Mar;13(3):245–264. doi: 10.1016/S0006-3495(73)85983-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Zarda P. R., Chien S., Skalak R. Elastic deformations of red blood cells. J Biomech. 1977;10(4):211–221. doi: 10.1016/0021-9290(77)90044-6. [DOI] [PubMed] [Google Scholar]

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