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. 1981 Nov;36(2):321–327. doi: 10.1016/S0006-3495(81)84734-0

The effect of tetramethylammonium on single sodium channel currents.

R Horn, J Patlak, C F Stevens
PMCID: PMC1327598  PMID: 6272896

Abstract

Voltage-dependent Na conductance of rat myotubes was studied by patch recordings of single-channels. The patches were excised from the cell with the patch electrode, and the cytoplasmic surface was bathed in either CsF or tetramethylammonium (TMA)-F. Inward currents were examined from -20 to -50 mV. In this range Cs and TMA both appeared to be nearly impermeant, but TMA blocked the channel in a voltage-dependent manner. A first-order blocking site was located a maximum of 89% of the way through the membrane field from the cytoplasmic surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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