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. 1987 Aug;52(2):347–350. doi: 10.1016/S0006-3495(87)83222-8

The calcium hypothesis and modulation of transmitter release by hyperpolarizing pulses.

R S Zucker 1
PMCID: PMC1330086  PMID: 3663838

Abstract

Small presynaptic conditioning hyperpolarizing pulses reduce transmitter release to a depolarizing stimulus by a substantial amount, with little effect on release by a subsequent depolarization. This result, obtained at neuromuscular junctions and the squid giant synapse, has been offered as a disproof of the calcium hypothesis of transmitter release or the residual calcium hypothesis of synaptic facilitation. However, calculations based on several formulations of these hypotheses are shown to be consistent with the experimental results, and no fundamental modification of the hypotheses is necessary.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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