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. 1975 Jan;244(1):253–262. doi: 10.1113/jphysiol.1975.sp010795

A calcium ionophore stimulating the secretion of catecholamines from the cat adrenal.

A G Garcia, S M Kirpekar, J C Prat
PMCID: PMC1330756  PMID: 1091727

Abstract

1. Experiments were performed on perfused cat adrenal glands to examine the effect of a calcium ionophore A-23187 in the secretion of catecholamines. 2. Ionophore (1-10 muM) caused a dose-dependent release of catecholamines and the output was about 100-fold greater at 10 mum than at 1 mum. 3. Release of catecholamines by the ionophore was dependent on the calcium concentration of the perfusion medium. Omission of calcium blocked the response to the ionophore while excess calcium facilitated it. 4. Magnesium antagonized the secretory response to the ionophore. Excess calcium overcame the inhibitory effect of magnesium. 5. The ionophore did not modify release of catecholamines by induced splanchnic nerve stimulation. 6. The results suggest that the ionophore, like depolarization, introduces calcium into the chromaffin cell to cause release of catecholamines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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