Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1975 Feb;245(2):409–424. doi: 10.1113/jphysiol.1975.sp010853

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

T S Miles, M Wiesendanger
PMCID: PMC1330794  PMID: 1142174

Abstract

1. In cats anaesthetized with pentobarbitone, the projection of climbing fibres (CFs) to the cerebellar cortex from trigeminal cutaneous branches and from the face area of the sensorimotor (SI) cortex was mapped, using the technique of laminar field potential analysis. 2. The CF projections from both the trigeminal nerve and the SI face area were found to be localized to the same cerebellar folia, viz. chiefly the ipsilateral lobule HVI, with a small overlap on to the adjacent folia of lobule V and crus Ia of HVIIA. Frequently a projection from the superficial radial nerve to part or all of this area, was also found. 3. A correspondence in the distribution and amplitudes of CF potentials evoked at most points by stimulation of the trigeminal nerve and the SI cortex was found. This implies a convergence of afferents from these two sources at or before the inferior olive. 4. In more than half of the cats, a small area of the cerebellar hemisphere was found, in which contralateral as well as ipsilateral trigeminal stimulation would evoke CF potentials. Usually inputs from the superficial radial nerve and the SI cortex also converged upon this area. 5. The organization of CF projections from trigeminal and superficial radial nerve afferents to the cerebellar hemisphere was found to occur in the same 'patchy' pattern of somatotopy that has been described for spinal nerve inputs to the anterior lobe. 6. One constant factor was found in the pattern of organization of CF projections to this area from cutaneous afferent nerves. That is, only the afferents from overlapping areas of skin projected to a given recording point: no instance of CF projections from trigeminal branches innervating discontinuous skin areas was observed.

Full text

PDF
410

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DARIAN-SMITH I., PHILLIPS G. SECONDARY NEURONES WITHIN A TRIGEMINO-CEREBELLAR PROJECTION TO THE ANTERIOR LOBE OF THE CEREBELLUM IN THE CAT. J Physiol. 1964 Jan;170:53–68. doi: 10.1113/jphysiol.1964.sp007313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eccles J. C., Llinás R., Sasaki K. The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J Physiol. 1966 Jan;182(2):268–296. doi: 10.1113/jphysiol.1966.sp007824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eccles J. C., Provini L., Strata P., Táboríková H. Analysis of electrical potentials evoked in the cerebellar anterior lobe by stimulation of hindlimb and forelimb nerves. Exp Brain Res. 1968;6(3):171–194. doi: 10.1007/BF00235123. [DOI] [PubMed] [Google Scholar]
  4. Eccles J. C., Provini L., Strata P., Táboríková H. Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe. Exp Brain Res. 1968;6(3):195–215. doi: 10.1007/BF00235124. [DOI] [PubMed] [Google Scholar]
  5. Eccles J. C. The cerebellum as a computer: patterns in space and time. J Physiol. 1973 Feb;229(1):1–32. doi: 10.1113/jphysiol.1973.sp010123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fennell E., Rowe M. J. Sensorimotor cortical influences on the climbing fibre input to cerebellar Purkyne cells. Brain Res. 1973 Sep 28;60(1):263–266. doi: 10.1016/0006-8993(73)90868-8. [DOI] [PubMed] [Google Scholar]
  7. Gordon M., Rubia F. J., Strata P. The effect of pentothal on the activity evoked in the cerebellar cortex. Exp Brain Res. 1973 Mar 29;17(1):50–62. doi: 10.1007/BF00234563. [DOI] [PubMed] [Google Scholar]
  8. Keller O., Vyklicky L., Sykova E. Reflexes from A delta and A alpha trigeminal afferents. Brain Res. 1972 Feb 25;37(2):330–332. doi: 10.1016/0006-8993(72)90680-4. [DOI] [PubMed] [Google Scholar]
  9. Kitai S. T., Táboríková H., Tsukahara N., Eccles J. C. The distribution to the cerebellar anterior lobe of the climbing and mossy fiber inputs from the plantar and palamar cutaneous afferents. Exp Brain Res. 1969;7(1):1–10. doi: 10.1007/BF00236104. [DOI] [PubMed] [Google Scholar]
  10. LARSELL O. The cerebellum of the cat and the monkey. J Comp Neurol. 1953 Aug;99(1):135–199. doi: 10.1002/cne.900990110. [DOI] [PubMed] [Google Scholar]
  11. Latham A., Paul D. H. Effects of sodium thiopentone on cerebellar neurone activity. Brain Res. 1971 Jan 8;25(1):212–215. doi: 10.1016/0006-8993(71)90585-3. [DOI] [PubMed] [Google Scholar]
  12. Leicht R., Rowe M. J., Schmidt R. F. Cutaneous convergence on to the climbing fibre input to cerebellar Purkyne cells. J Physiol. 1973 Feb;228(3):601–618. doi: 10.1113/jphysiol.1973.sp010102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marr D. A theory of cerebellar cortex. J Physiol. 1969 Jun;202(2):437–470. doi: 10.1113/jphysiol.1969.sp008820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Miles T. S., Wiesendanger M. Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat. J Physiol. 1975 Feb;245(2):425–445. doi: 10.1113/jphysiol.1975.sp010854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Miller S., Nezlina N., Oscarsson O. Projection and convergence patterns in climbing fibre paths to cerebellar anterior lobe activated from cerebral cortex and spinal cord. Brain Res. 1969 Jun;14(1):230–233. doi: 10.1016/0006-8993(69)90045-6. [DOI] [PubMed] [Google Scholar]
  16. Oscarsson O. Termination and functional organization of the dorsal spino-olivocerebellar path. J Physiol. 1969 Jan;200(1):129–149. doi: 10.1113/jphysiol.1969.sp008685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Oscarsson O. Termination and functional organization of the ventral spino-olivocerebellar path. J Physiol. 1968 May;196(2):453–478. doi: 10.1113/jphysiol.1968.sp008518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Provini L., Redman S., Strata P. Mossy and climbing fibre organization on the anterior lobe of the cerebellum activated by forelimb and hindlimb areas of the sensorimotor cortex. Exp Brain Res. 1968;6(3):216–233. doi: 10.1007/BF00235125. [DOI] [PubMed] [Google Scholar]
  19. Thexton A. J. Jaw opening and jaw closing reflexes in the cat. J Physiol. 1968 Jul;197(1):34P–35P. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES