Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1972 Dec;227(1):233–242. doi: 10.1113/jphysiol.1972.sp010029

The effect of distending the atrial appendages on urine flow in the dog

C T Kappagoda, R J Linden, H M Snow
PMCID: PMC1331272  PMID: 4646580

Abstract

1. Distension of the atrial appendages resulted in a diuresis, an increase in the rate of Na+ excretion and an increase in heart rate.

2. Both the urinary and heart rate responses to distension of the appendages were either abolished or much reduced by crushing the bases of the appendages.

3. The diuresis in response to distension of the atrial appendages is similar to that previously described in response to distension of the pulmonary vein-atrial junctions by Ledsome & Linden (1968).

4. It is concluded that stimulation of nerve endings within the atrial appendages results in a reflex increase in urine flow and heart rate.

Full text

PDF
235

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HENRY J. P., PEARCE J. W. The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow. J Physiol. 1956 Mar 28;131(3):572–585. doi: 10.1113/jphysiol.1956.sp005483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HOLMES R. L. Structures in the atrial endocardium of the dog which stain with methylene blue, and the effects of unilateral vagotomy. J Anat. 1957 Apr;91(2):259–266. [PMC free article] [PubMed] [Google Scholar]
  3. Johnston B. D. Nerve endings in the human endocardium. Am J Anat. 1968 May;122(3):621–629. doi: 10.1002/aja.1001220312. [DOI] [PubMed] [Google Scholar]
  4. Kappagoda C. T., Linden R. J., Saunders D. A. The effect of distending the right and left atrial appendages in the dog. J Physiol. 1972 Apr;222(1):35P–36P. [PubMed] [Google Scholar]
  5. Kappagoda C. T., Linden R. J., Snow H. M. A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium. J Physiol. 1972 Jan;220(1):177–197. doi: 10.1113/jphysiol.1972.sp009700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kappagoda C. T., Linden R. J., Snow H. M. Atrial appendages and urine flow in the dog. J Physiol. 1972 Jul;224(1):46P–47P. [PubMed] [Google Scholar]
  7. LEDSOME J. R., LINDEN R. J. A REFLEX INCREASE IN HEART RATE FROM DISTENSION OF THE PULMONARY-VEIN-ATRIAL JUNCTIONS. J Physiol. 1964 Apr;170:456–473. doi: 10.1113/jphysiol.1964.sp007343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LEDSOME J. R., LINDEN R. J., O'CONNOR W. J. The mechanisms by which distension of the left atrium produces diuresis in anaesthetized dogs. J Physiol. 1961 Nov;159:87–100. doi: 10.1113/jphysiol.1961.sp006794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ledsome J. R., Linden R. J., Norman J. An anaesthetic machine for dogs. J Physiol. 1967 Jul;191(2):61P–62P. [PubMed] [Google Scholar]
  10. Ledsome J. R., Linden R. J., Norman J., Snow H. M. The measurement of pH, PCO2 and PO2 in blood. J Physiol. 1967 Jul;191(2):59P–60P. [PubMed] [Google Scholar]
  11. Ledsome J. R., Linden R. J. The role of left atrial receptors in th diuretic response to left atrial distension. J Physiol. 1968 Sep;198(2):487–503. doi: 10.1113/jphysiol.1968.sp008619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MILLER M. R., KASAHARA M. STUDIES ON THE NERVE ENDINGS IN THE HEART. Am J Anat. 1964 Sep;115:217–233. doi: 10.1002/aja.1001150203. [DOI] [PubMed] [Google Scholar]
  13. Sleight P., Widdicombe J. G. Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle. J Physiol. 1965 Nov;181(2):235–258. doi: 10.1113/jphysiol.1965.sp007758. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES