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. 1972 Jul;224(2):317–332. doi: 10.1113/jphysiol.1972.sp009897

An attempt at an analysis of the factors determining the time course of the end-plate current

I. The effects of prostigmine and of the ratio of Mg2+ to Ca2+

M Kordaš, I Gabrovec, M Kordaš, B Popovič
PMCID: PMC1331492  PMID: 4341936

Abstract

1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end-plate current.

2. The end-plate current was measured by `clamping' the membrane potential during neuromuscular transmission.

3. The falling phase of the end-plate current was found to consist of a non-exponential, and an exponential portion, the duration of both of which varies under different experimental conditions.

4. The results suggest that the rate constants determining the dissociation of the receptor—mediator complex seem greatly to influence the time course of the end-plate current.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beránek R., Vyskocil F. The effect of atropine on the frog sartorius neuromuscular junction. J Physiol. 1968 Mar;195(2):493–503. doi: 10.1113/jphysiol.1968.sp008470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Colomo F., Rahamimoff R. Interaction between sodium and calcium ions in the process of transmitter release at the neuromuscular junction. J Physiol. 1968 Sep;198(1):203–218. doi: 10.1113/jphysiol.1968.sp008602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DEL CASTILLO J., KATZ B. Statistical factors involved in neuromuscular facilitation and depression. J Physiol. 1954 Jun 28;124(3):574–585. doi: 10.1113/jphysiol.1954.sp005130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ECCLES J. C., MacFARLANE W. V. Actions of anti-cholinesterases on endplate potential of frog muscle. J Neurophysiol. 1949 Jan;12(1):59–80. doi: 10.1152/jn.1949.12.1.59. [DOI] [PubMed] [Google Scholar]
  5. FATT P., KATZ B. An analysis of the end-plate potential recorded with an intracellular electrode. J Physiol. 1951 Nov 28;115(3):320–370. doi: 10.1113/jphysiol.1951.sp004675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HUBBARD J. I., WILLIS W. D. Hyperpolarization of mammalian motor nerve terminals. J Physiol. 1962 Aug;163:115–137. doi: 10.1113/jphysiol.1962.sp006961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HUTTER O. F. Post-tetanic restoration of neuromuscular transmission blocked by D-tubocurarine. J Physiol. 1952 Oct;118(2):216–227. doi: 10.1113/jphysiol.1952.sp004788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. JENKINSON D. H. The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction. J Physiol. 1957 Oct 30;138(3):434–444. doi: 10.1113/jphysiol.1957.sp005860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KATZ B., MILEDI R. THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS. Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496–503. doi: 10.1098/rspb.1965.0017. [DOI] [PubMed] [Google Scholar]
  10. Kelly J. S. The antagonism of Ca2+ by Na+ and other monovalent ions at the frog neuromuscular junction. Q J Exp Physiol Cogn Med Sci. 1968 Jul;53(3):239–249. doi: 10.1113/expphysiol.1968.sp001967. [DOI] [PubMed] [Google Scholar]
  11. Kordas M. A study of the end-plate potential in sodium deficient solution. J Physiol. 1968 Sep;198(1):81–90. doi: 10.1113/jphysiol.1968.sp008594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kordas M. An attempt at an analysis of the factors determining the time course of the end-plate current. II. Temperature. J Physiol. 1972 Jul;224(2):333–348. doi: 10.1113/jphysiol.1972.sp009898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kuba K., Tomita T. Effect of prostigmine on the time course of the end-plate potential in the rat diaphragm. J Physiol. 1971 Mar;213(3):533–544. doi: 10.1113/jphysiol.1971.sp009398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Maeno T. Analysis of sodium and potassium conductances in the procaine end-plate potential. J Physiol. 1966 Apr;183(3):592–606. doi: 10.1113/jphysiol.1966.sp007886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rahamimoff R. A dual effect of calcium ions on neuromuscular facilitation. J Physiol. 1968 Mar;195(2):471–480. doi: 10.1113/jphysiol.1968.sp008468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Steinbach A. B. A kinetic model for the action of xylocaine on receptors for acetylcholine. J Gen Physiol. 1968 Jul;52(1):162–180. doi: 10.1085/jgp.52.1.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Steinbach A. B. Alteration by xylocaine (lidocaine) and its derivatives of the time course of the end plate potential. J Gen Physiol. 1968 Jul;52(1):144–161. doi: 10.1085/jgp.52.1.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. TAKEUCHI A., TAKEUCHI N. Active phase of frog's end-plate potential. J Neurophysiol. 1959 Jul;22(4):395–411. doi: 10.1152/jn.1959.22.4.395. [DOI] [PubMed] [Google Scholar]
  19. Werman R. An electrophysiological approach to drug-receptor mechanisms. Comp Biochem Physiol. 1969 Sep 15;30(6):997–1017. doi: 10.1016/0010-406x(69)91038-x. [DOI] [PubMed] [Google Scholar]

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