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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 1994 Jul;62(1):45–56. doi: 10.1901/jeab.1994.62-45

Tolerance to cocaine's rate-increasing effects upon repeated administration.

K F Schama 1, M N Branch 1
PMCID: PMC1334366  PMID: 8064212

Abstract

Four squirrel monkeys responded daily under a fixed-interval 5-min or 8-min schedule of food-pellet delivery. Cocaine (0.03 to 1.7 mg/kg) and saline were injected before occasional daily sessions (acute administration). Some doses of cocaine produced substantial overall increases in response rate for 3 of the subjects; effects were less substantial for the remaining subject, who exhibited modest increases in response rate early in the session and during the middle portion of the intervals. A dose that increased response rate when administered acutely was then administered before each session (chronic administration). Chronic administration resulted in a reduction in the increases in response rate seen under acute administration for all subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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