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. 1974 Jul;14(7):546–562. doi: 10.1016/S0006-3495(74)85934-5

A Model for the Transient and Steady-State Mechanical Behavior of Contracting Muscle

F J Julian, K R Sollins, M R Sollins
PMCID: PMC1334517  PMID: 4836669

Abstract

A model was developed which can simulate both the transient and steady-state mechanical behavior of contracting skeletal striated muscle. Thick filament cross-bridges undergo cycles of attachment to and detachment from thin filament sites. Cross-bridges can attach only while in the first of two stable states. Force is then generated by a transition to the second state after which detachment can occur. Cross-bridges are assumed to be connected to the thin filaments by an elastic element whose extension or compression influences the rate constants for attachment, detachment, and changes between states. The model was programmed for a digital computer and attempts made to match both the transient and the steady-state responses of the model to that of real muscle in two basic types of experiment: force response to sudden change in length and length response to sudden reduction of load from Po. Values for rate constants and other parameters were chosen to try to match the model's output to results from real muscles, while at the same time trying to accommodate structural and biochemical information.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HUXLEY A. F. Muscle structure and theories of contraction. Prog Biophys Biophys Chem. 1957;7:255–318. [PubMed] [Google Scholar]
  2. Huxley A. F. A note suggesting that the cross-bridge attachment during muscle contraction may take place in two stages. Proc R Soc Lond B Biol Sci. 1973 Feb 27;183(1070):83–86. doi: 10.1098/rspb.1973.0006. [DOI] [PubMed] [Google Scholar]
  3. Huxley A. F., Simmons R. M. Proposed mechanism of force generation in striated muscle. Nature. 1971 Oct 22;233(5321):533–538. doi: 10.1038/233533a0. [DOI] [PubMed] [Google Scholar]
  4. Huxley A. F. The activation of striated muscle and its mechanical response. Proc R Soc Lond B Biol Sci. 1971 Jun 15;178(1050):1–27. doi: 10.1098/rspb.1971.0049. [DOI] [PubMed] [Google Scholar]
  5. Huxley H. E., Brown W. The low-angle x-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor. J Mol Biol. 1967 Dec 14;30(2):383–434. doi: 10.1016/s0022-2836(67)80046-9. [DOI] [PubMed] [Google Scholar]
  6. Huxley H. E. The structural basis of muscular contraction. Proc R Soc Lond B Biol Sci. 1971 Jun 29;178(1051):131–149. doi: 10.1098/rspb.1971.0057. [DOI] [PubMed] [Google Scholar]
  7. Julian F. J. Activation in a skeletal muscle contraction model with a modification for insect fibrillar muscle. Biophys J. 1969 Apr;9(4):547–570. doi: 10.1016/S0006-3495(69)86403-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mommaerts W. F. Energetics of muscular contraction. Physiol Rev. 1969 Jul;49(3):427–508. doi: 10.1152/physrev.1969.49.3.427. [DOI] [PubMed] [Google Scholar]
  9. Podolsky R. J., Nolan A. C., Zaveler S. A. Cross-bridge properties derived from muscle isotonic velocity transients. Proc Natl Acad Sci U S A. 1969 Oct;64(2):504–511. doi: 10.1073/pnas.64.2.504. [DOI] [PMC free article] [PubMed] [Google Scholar]

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