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. 1989 Mar;51(2):173–184. doi: 10.1901/jeab.1989.51-173

Differential effects of pentobarbital and cocaine on punished and nonpunished responding.

S I Dworkin 1, C Bimle 1, T Miyauchi 1
PMCID: PMC1338849  PMID: 2708936

Abstract

Similar rates of punished and nonpunished responding, maintained with equated rates of reinforcement, were established in pairs of rats. One subject of each pair was exposed to a random-ratio schedule of food presentation. The interreinforcement intervals for this subject comprised the intervals of a random-interval schedule of reinforcement for the other (yoked) rat. The random-ratio schedule maintained rates of responding higher than those maintained by the same rate of reinforcement schedule according to the yoked random-interval contingency. A random-ratio schedule of electric foot shock added to the random-ratio schedule of food presentation suppressed rates of responding such that similar rates of responding were observed in rats of both groups. Pentobarbital (3.0 to 17.0 mg/kg) increased punished responding at doses that had little effect on or decreased nonpunished responding, whereas cocaine (5.6 to 30 mg/kg) increased nonpunished responding at doses that decreased or did not alter punished responding. Qualitatively different effects of pharmacological agents on punished and nonpunished responding can be obtained using procedures that generate similar rates and temporal patterns of punished and nonpunished responding. The effects of pentobarbital and cocaine on responding can be determined by factors other than simply the baseline rate of responding.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett J. E. Behavioral history as a determinant of the effects of d-amphetamine on punished behavior. Science. 1977 Oct 7;198(4312):67–69. doi: 10.1126/science.408925. [DOI] [PubMed] [Google Scholar]
  2. Branch M. N., Gollub L. R. A detailed analysis of the effects of d-amphetamine on behavior under fixed-interval schedules. J Exp Anal Behav. 1974 May;21(3):519–539. doi: 10.1901/jeab.1974.21-519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Branch M. N., Nicholson G., Dworkin S. I. Punishment-specific effects of pentobarbital: dependency on the type of punisher. J Exp Anal Behav. 1977 Nov;28(3):285–293. doi: 10.1901/jeab.1977.28-285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COOK L., CATANIA A. C. EFFECTS OF DRUGS ON AVOIDANCE AND ESCAPE BEHAVIOR. Fed Proc. 1964 Jul-Aug;23:818–835. [PubMed] [Google Scholar]
  5. DEWS P. B. Studies on behavior. I. Differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward. J Pharmacol Exp Ther. 1955 Apr;113(4):393–401. [PubMed] [Google Scholar]
  6. Foree D. D., Moretz F. H., McMillan D. E. Drugs and punished responding. II. d-Amphetamine-induced increases in punished responding. J Exp Anal Behav. 1973 Sep;20(2):291–300. doi: 10.1901/jeab.1973.20-291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GELLER I., KULAK J. T., Jr, SEIFTER J. The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination. Psychopharmacologia. 1962 Oct 31;3:374–385. doi: 10.1007/BF00408322. [DOI] [PubMed] [Google Scholar]
  8. Geller I., Hartmann R. J., Blum K. The effects of low-dose combinations of D-amphetamine and cocaine on experimentally induced conflict in the rat. Curr Ther Res Clin Exp. 1972 Apr;14(4):220–224. [PubMed] [Google Scholar]
  9. Goeders N. E., Smith J. E. Cortical dopaminergic involvement in cocaine reinforcement. Science. 1983 Aug 19;221(4612):773–775. doi: 10.1126/science.6879176. [DOI] [PubMed] [Google Scholar]
  10. Jeffery D. R., Barrett J. E. Effects of chlordiazepoxide on comparable rates of punished and unpunished responding. Psychopharmacology (Berl) 1979 Jun 28;64(1):9–11. doi: 10.1007/BF00427337. [DOI] [PubMed] [Google Scholar]
  11. Kelleher R. T., Morse W. H. Determinants of the specificity of behavioral effects of drugs. Ergeb Physiol. 1968;60:1–56. doi: 10.1007/BFb0107250. [DOI] [PubMed] [Google Scholar]
  12. Kennedy L. T., Hanbauer I. Sodium-sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites. J Neurochem. 1983 Jul;41(1):172–178. doi: 10.1111/j.1471-4159.1983.tb13666.x. [DOI] [PubMed] [Google Scholar]
  13. McKearney J. W., Barrett J. E. Punished behavior: increases in responding after d-amphetamine. Psychopharmacologia. 1975;41(1):23–26. doi: 10.1007/BF00421301. [DOI] [PubMed] [Google Scholar]
  14. McMillan D. E. Determinants of drug effects on punished responding. Fed Proc. 1975 Aug;34(9):1870–1879. [PubMed] [Google Scholar]
  15. McMillan D. E. Drugs and punished responding. I. Rate-dependent effects under multiple schedules. J Exp Anal Behav. 1973 Jan;19(1):133–145. doi: 10.1901/jeab.1973.19-133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sanger D. J., Blackman D. E. Rate-dependent effects of drugs: a review of the literature. Pharmacol Biochem Behav. 1976 Jan;4(1):73–83. doi: 10.1016/0091-3057(76)90178-7. [DOI] [PubMed] [Google Scholar]
  17. Schoemaker H., Pimoule C., Arbilla S., Scatton B., Javoy-Agid F., Langer S. Z. Sodium dependent [3H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinsons disease. Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):227–235. doi: 10.1007/BF00501873. [DOI] [PubMed] [Google Scholar]
  18. Spealman R. D. Comparison of drug effects on responding punished by pressurized air or electric shock delivery in squirrel monkeys: pentobarbital, chlordiazepoxide, d-amphetamine and cocaine. J Pharmacol Exp Ther. 1979 May;209(2):309–315. [PubMed] [Google Scholar]
  19. Wilson M. C. The effect of cocaine and D-amphetamine on punished responding. Arch Int Pharmacodyn Ther. 1977 May;227(1):98–105. [PubMed] [Google Scholar]
  20. Wuttke W., Kelleher R. T. Effects of some benzodiazepines on punished and unpunished behavior in the pigeon. J Pharmacol Exp Ther. 1970 Apr;172(2):397–405. [PubMed] [Google Scholar]

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