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. 1974 Jul;180(1):103–109. doi: 10.1097/00000658-197407000-00016

Acute Hemodilution: Its Effect on Hemodynamics and Oxygen Transport in Anesthetized Man

Hillel Laks, Robert N Pilon, W Peter Klovekorn, Warwick Anderson, John R MacCallum, Nicholas E O'Connor
PMCID: PMC1343616  PMID: 4151749

Abstract

The effects of acute normovolemic hemodilution on hemodynamics, oxygen transport, tissue perfusion and blood volume were studied. The subjects were four patients undergoing total hip replacement with prebleeding and hemodilution under fluoroxene and nitrous oxide anesthesia. The hematocrit was reduced to 29% and 21% by bleeding in two steps with simultaneous infusion of plasmanate and lactated Ringer's solution. The major compensation was a rise in CO to 123% and 136%. Systemic oxygen transport (COX arterial O2 content) was only slightly reduced and the arteriovenous oxygen difference decreased. Tissue perfusion remained excellent. Blood volume was slightly expanded. The procedure was well tolerated by this group of selected patients, and homologous blood utilization was markedly reduced.

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Selected References

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