Skip to main content
Annals of Surgery logoLink to Annals of Surgery
. 1975 Feb;181(2):151–156. doi: 10.1097/00000658-197502000-00004

What is clinical smoke poisoning?

B A Zikria, D C Budd, F Floch, J M Ferrer
PMCID: PMC1343744  PMID: 1111445

Abstract

In this 13-year study, 51 patients were admitted with the primary diagnosis of "smoke poisoning" "carbon monoxide (CO) poisoning" or "respiratory burns." Forty patients (78%) had diagnosis of smoke poisoning with minor or no skin burns. The study indicated that clinical diagnosis of CO poisoning cannot be made reliably without carboxyhemoglobin (COHg) determination and that smoke poisoning patients often had CO poisoning. Seventeen of 19 smoke poisoning patients (89%) had CO poisoning above COHb levels of 15% saturation. Carbon monoxide was successfully removed from the blood by improving alveolar ventilation and oxygen concentration. However, there were 2 smoke poisoning deaths as the result of gaseous chemical injury. There was a correlation coefficient of 0.87 between initial COHg levels and patients' hospital days primarily determined by patients' pulmonary complications. Since CO is non-irritating, COHb levels may be used as an additional indicator of suspected pulmonary injury by noxious combustion gases.

Full text

PDF
156

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coburn R. F., Forster R. E., Kane P. B. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J Clin Invest. 1965 Nov;44(11):1899–1910. doi: 10.1172/JCI105296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coburn R. F., Williams W. J., White P., Kahn S. B. The production of carbon monoxide from hemoglobin in vivo. J Clin Invest. 1967 Mar;46(3):346–356. doi: 10.1172/JCI105536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HASELKORN R., DOTY P. The reaction of formaldehyde with polynucleotides. J Biol Chem. 1961 Oct;236:2738–2745. [PubMed] [Google Scholar]
  4. JOHNSON R. L., Jr, TAYLOR H. F., LAWSON W. H., Jr MAXIMAL DIFFUSING CAPACITY OF THE LUNG FOR CARBON MONOXIDE. J Clin Invest. 1965 Mar;44:349–355. doi: 10.1172/JCI105148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Moritz A. R., Henriques F. C., McLean R. The Effects of Inhaled Heat on the Air Passages and Lungs: An Experimental Investigation. Am J Pathol. 1945 Mar;21(2):311–331. [PMC free article] [PubMed] [Google Scholar]
  6. PHILLIPS A. W., COPE O. Burn therapy. II. The revelation of respiratory tract damage as a principal killer of the burned patient. Ann Surg. 1962 Jan;155:1–19. doi: 10.1097/00000658-196201000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rosenberg E., MacLean L. D. Effect of high oxygen tensions on diffusing capacity for CO and Krogh's K. J Appl Physiol. 1967 Jul;23(1):11–17. doi: 10.1152/jappl.1967.23.1.11. [DOI] [PubMed] [Google Scholar]
  8. SIM V. M., PATTLE R. E. Effect of possible smog irritants on human subjects. J Am Med Assoc. 1957 Dec 14;165(15):1908–1913. doi: 10.1001/jama.1957.02980330010003. [DOI] [PubMed] [Google Scholar]
  9. SMITH G. CLINICAL EXPERIENCE AND IMPLICATIONS OF HYPERBARIC OXYGENATION. CARBON MONOXIDE POISONING. Ann N Y Acad Sci. 1965 Jan 21;117:684–687. [PubMed] [Google Scholar]
  10. SMITH G., LEDINGHAM I. M., SHARP G. R., NORMAN J. N., BATES E. H. Treatment of coal-gas poisoning with oxygen at 2 atmospheres pressure. Lancet. 1962 Apr 21;1(7234):816–819. doi: 10.1016/s0140-6736(62)91836-6. [DOI] [PubMed] [Google Scholar]
  11. Zikria B. A., Ferrer J. M., Floch H. F. The chemical factors contributing to pulmonary damage in "smoke poisoning". Surgery. 1972 May;71(5):704–709. [PubMed] [Google Scholar]
  12. Zikria B. A., Sturner W. Q., Astarjian N. K., Fox C. L., Jr, Ferrer J. M., Jr Respiratory tract damage in burns: pathophysiology and therapy. Ann N Y Acad Sci. 1968 Aug 14;150(3):618–626. doi: 10.1111/j.1749-6632.1968.tb14714.x. [DOI] [PubMed] [Google Scholar]
  13. Zikria B. A., Weston G. C., Chodoff M., Ferrer J. M. Smoke and carbon monoxide poisoning in fire victims. J Trauma. 1972 Aug;12(8):641–645. doi: 10.1097/00005373-197208000-00001. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES