Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1975 Feb;181(2):191–195. doi: 10.1097/00000658-197502000-00012

Effect of antrectomy and subsequent vagotomy on the serum gastrin response to food in dogs.

R A Booth, D D Reeder, J C Thompson
PMCID: PMC1343752  PMID: 1111451

Abstract

The effect of food on serum gastrin and gastric acid secretion has been studied in dogs with denervated pouches before and after antrectomy and subsequent vagotomy. A Billroth I anastomosis was used in one group of dogs and a Billroth II in the other. Serum gastrin was measured by radioimmunoassay. In both groups of dogs antrectomy significantly depressed mean basal levels of serum gastrin and abolished the rise in serum gastrin in response to a meat meal. Meal-induced pouch acid secretion was considerably lowered by antrectomy after either Billroth I or Billroth II anastomosis. Vagotomy after antrectomy increased basal levels of gastrin, but did not restore the serum gastrin response to a meat meal in either group of dogs. It is suggested that biologically active forms of gastrin are released from the antrum in response to a meal. Biologically inactive basal levels of gastrin apparently originate from extra-antral sources. The post-vagotomy increase in basal (static) gastrin suggests vagal control of the metabolism of static, extra-antral gastrin.

Full text

PDF
195

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker H. D., Reeder D. D., Thompson J. C. Effect of truncal vagotomy with pyloroplasty or with antrectomy on food-stimulated gastrin values in patients with duodenal ulcer. Surgery. 1973 Oct;74(4):580–586. [PubMed] [Google Scholar]
  2. Becker H. D., Reeder D. D., Thompson J. C. Extraction of circulating endogenous gastrin by the small bowel. Gastroenterology. 1973 Dec;65(6):903–906. [PubMed] [Google Scholar]
  3. Berson S. A., Yllow R. S. Nature of immunoreactive gastrin extracted from tissues of gastrointestinal tract. Gastroenterology. 1971 Feb;60(2):215–222. [PubMed] [Google Scholar]
  4. Booth R. A., Reeder D. D., Hjelmquist U. B., Brandt E. N., Jr, Thompson J. C. Renal inactivation of endogenous gastrin in dogs. Arch Surg. 1973 Jun;106(6):851–854. doi: 10.1001/archsurg.1973.01350180085024. [DOI] [PubMed] [Google Scholar]
  5. Charters A. C., Reeder D. D., Thompson J. C. Measurement of gastrin in the gastrointestinal mucosa by radio-immunoassay. Surg Forum. 1969;20:310–311. [PubMed] [Google Scholar]
  6. Evans J. C., Reeder D. D., Becker H. D., Thompson J. C. Extraction of circulating endogenous gastrin by the gastric fundus. Gut. 1974 Feb;15(2):112–115. doi: 10.1136/gut.15.2.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jackson B. M., Reeder D. D., Thompson J. C. Dynamic characteristics of gastrin release. Am J Surg. 1972 Feb;123(2):137–142. doi: 10.1016/0002-9610(72)90323-6. [DOI] [PubMed] [Google Scholar]
  8. Korman M. G., Soveny C., Hansky J. Extragastric gastrin. Gut. 1972 May;13(5):346–348. doi: 10.1136/gut.13.5.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lanciault G., Bonoma C., Karreman G., Brooks F. P. Kinetics of gastrin release and degradation in response to electrical vagal stimulation in the dog. Proc Soc Exp Biol Med. 1973 Mar;142(3):740–743. doi: 10.3181/00379727-142-37106. [DOI] [PubMed] [Google Scholar]
  10. Lomský R., Langer F., Vortel V. Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans. Nature. 1969 Aug 9;223(5206):618–619. doi: 10.1038/223618a0. [DOI] [PubMed] [Google Scholar]
  11. Middleton M. D., Kelly K. A., Nyhus L. M., Harkins H. N. Selective vagal effects on the intestinal phase of gastric secretion. Gut. 1965 Jun;6(3):296–300. doi: 10.1136/gut.6.3.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reeder D. D., Jackson B. M., Brandt E. N., Jr, Thompson J. C. Rate and pattern of disappearance of exogenous gastrin in dogs. Am J Physiol. 1972 Jun;222(6):1571–1574. doi: 10.1152/ajplegacy.1972.222.6.1571. [DOI] [PubMed] [Google Scholar]
  13. Stern D. H., Walsh J. H. Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin. Gastroenterology. 1973 Mar;64(3):363–369. [PubMed] [Google Scholar]
  14. Tepperman B. L., Walsh J. H., Preshaw R. M. Effect of antral denervation on gastrin release by sham feeding and insulin hypoglycemia in dogs. Gastroenterology. 1972 Dec;63(6):973–980. [PubMed] [Google Scholar]
  15. Thompson J. C., Reeder D. D., Bunchman H. H., Becker H. D., Brandt E. N., Jr Effect of secretin on circulating gastrin. Ann Surg. 1972 Sep;176(3):384–393. doi: 10.1097/00000658-197209000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walsh J. H., Csendes A., Grossman M. I. Effect of truncal vagotomy on gastrin release and Heidenhain pouch acid secretion in response to feeding in dogs. Gastroenterology. 1972 Oct;63(4):593–600. [PubMed] [Google Scholar]
  17. Watson L. C., Reeder D. D., Becker H. D., LaGrone L., Thompson J. C. Gastrin concentrations in upper gastrointestinal mucosa in dogs. Surgery. 1974 Sep;76(3):419–422. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES