Skip to main content
Annals of Surgery logoLink to Annals of Surgery
. 1976 May;183(5):517–532. doi: 10.1097/00000658-197605000-00009

The treatment of hemangiomas: with special reference to the role of steroid therapy.

M T Edgerton
PMCID: PMC1344338  PMID: 776106

Abstract

Hemangiomas are the most common of all human birth defects. The author has reviewed a 25-year personal experience with treatment of over 1000 patients with a variety of common and rare developmental vascular anomalies. Attention is given to a more useful clinical classification of these disorders. The classification is intended to be helpful in estimating prognosis of the lesions and as a guide to the choice of therapy. Many treatment modalities are evaluated--some successful and some quite disappointing. Surgical excision, irradiation, CO2 freezing, sclerosing agents, cauterization, steroid therapy and watchful waiting are among the treatment methods evaluated. High dose--short course Prednisone therapy has proved to be a major new addition to the treatment of massive juvenile capillary hemangiomas. Numerous misconceptions have appeared in the medical literature. These are noted and a philosophic basis for present day management is suggested for each type angioma. The roles of growth, resolution, histologic picture and sense of deformity are considered in viewing the surgeon's approach to these difficult and challenging problems. Some evidence and speculations are offered as to the etiology, neurogenic influences and physiological dynamics of the various hemangiomas.

Full text

PDF
530

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett J. E., Zook E. G. Treatment of arteriovenous fistulas in cavernous hemangiomas of face by muscle embolization. Case report. Plast Reconstr Surg. 1972 Jul;50(1):84–87. doi: 10.1097/00006534-197207000-00021. [DOI] [PubMed] [Google Scholar]
  2. Brown S. H., Jr, Neerhout R. C., Fonkalsrud E. W. Prednisone therapy in the management of large hemangiomas in infants and children. Surgery. 1972 Feb;71(2):168–173. [PubMed] [Google Scholar]
  3. Cunningham D. S., Paletta F. X. Control of arteriovenous fistulae in massive facial hemangioma by muscle emboli. Case report. Plast Reconstr Surg. 1970 Sep;46(3):305–308. doi: 10.1097/00006534-197009000-00020. [DOI] [PubMed] [Google Scholar]
  4. Fost N. C., Esterly N. B. Successful treatment of juvenile hemangiomas with prednisone. J Pediatr. 1968 Mar;72(3):351–357. doi: 10.1016/s0022-3476(68)80208-2. [DOI] [PubMed] [Google Scholar]
  5. Gray G. R., Freedman S. I., Kagan A. R. Fibrosarcoma: a complication of interstitial radiation therapy for a benign haemangioma occurring after 18 years. Br J Radiol. 1974 Jan;47(553):60–61. doi: 10.1259/0007-1285-47-553-60. [DOI] [PubMed] [Google Scholar]
  6. HEFLEY B. F., SMITH P., Jr, KITTLER F. J., JOHNSTON T. G., CAZORT A. G. THE USE OF TRIAMCINOLONE ACETONIDE INJECTIONS IN THE TREATMENT OF ALLERGIC PROBLEMS. Ann Allergy. 1964 May;22:244–251. [PubMed] [Google Scholar]
  7. LEWIS J. R., Jr The treatment of hemangiomas. Plast Reconstr Surg (1946) 1957 Mar;19(3):201–212. doi: 10.1097/00006534-195703000-00003. [DOI] [PubMed] [Google Scholar]
  8. Li F. P., Cassady J. R., Barnett E. Cancer mortality following irradiation in infancy for hemangioma. Radiology. 1974 Oct;113(1):177–178. doi: 10.1148/113.1.177. [DOI] [PubMed] [Google Scholar]
  9. Longacre J. J., Benton C., Unterthiner R. A. Treatment of facial hemangioma by intravascular embolization with silicone spheres. Case report. Plast Reconstr Surg. 1972 Dec;50(6):618–621. doi: 10.1097/00006534-197212000-00019. [DOI] [PubMed] [Google Scholar]
  10. Matthews D. N. Hemangiomata. Plast Reconstr Surg. 1968 Jun;41(6):528–535. doi: 10.1097/00006534-196806000-00003. [DOI] [PubMed] [Google Scholar]
  11. Morgan J. F., Schow C. E., Jr Use of sodium morrhuate in the management of hemangiomas. J Oral Surg. 1974 May;32(5):363–366. [PubMed] [Google Scholar]
  12. Overcash K. E., Putney F. J. Subglottic hemangioma of the larynx treated with steroid therapy. Laryngoscope. 1973 May;83(5):679–682. doi: 10.1288/00005537-197305000-00003. [DOI] [PubMed] [Google Scholar]
  13. Prensky A. L., Gado M. Angiographic resolution of a neonatal intracranial cavernous hemangioma coincident with steroid therapy. Case report. J Neurosurg. 1973 Jul;39(1):99–103. doi: 10.3171/jns.1973.39.1.0099. [DOI] [PubMed] [Google Scholar]
  14. WYMAN L. C., FULTON G. P., SHULMAN M. H. Direct observations on the circulation in the hamster cheek pouch in adrenal insufficiency and experimental hypercorticalism. Ann N Y Acad Sci. 1953 Jul 17;56(4):643–658. doi: 10.1111/j.1749-6632.1953.tb27386.x. [DOI] [PubMed] [Google Scholar]
  15. Weber G. Letter: The treatment of cavernous haemangioma with topical betamethasone 17 valerate. Br J Dermatol. 1973 Dec;89(6):649–651. doi: 10.1111/j.1365-2133.1973.tb07596.x. [DOI] [PubMed] [Google Scholar]
  16. ZWEIFACH B. W., SHORR E., BLACK M. M. The influence of the adrenal cortex on behavior of terminal vascular bed. Ann N Y Acad Sci. 1953 Jul 17;56(4):626–633. doi: 10.1111/j.1749-6632.1953.tb27383.x. [DOI] [PubMed] [Google Scholar]
  17. Zarem H. A., Edgerton M. T. Induced resolution of cavernous hemangiomas following prednisolone therapy. Plast Reconstr Surg. 1967 Jan;39(1):76–83. doi: 10.1097/00006534-196701000-00010. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES