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. 1980 Mar;191(3):276–281. doi: 10.1097/00000658-198003000-00004

Antral gastrin cell hyperplasia in patients with peptic ulcer.

F Keuppens, G Willems, J De Graef, M C Woussen-Colle
PMCID: PMC1344696  PMID: 7362294

Abstract

The total number of gastrin (G) cells in the stomach was determined by using a histologic counting method and planimetry in ulcerous and nonulcerous patients. The preoperative basal and postprandial serum gastrin values and the gastrin cell mass in the gastrectomy specimen could be compared in 16 surgical patients. There was a significant correlation between the integrated gastrin response to feeding and the total gastrin cell number in the stomach. No correlation was found between the basal serum gastrin level and the total gastrin cell count. A total gastrin cell number higher than 50 million was found in the stomach of three duodenal ulcer patients with preoperative postprandial hypergastrinemia as well as in one patient with normal serum gastrin values. Gastrin cell counts between 6 and 42 million were found in control stomachs and in patients with gastric ulcer. Preoperative feeding tests could be useful to select patients with an elevated antral G cell number.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avrameas S., Bouteille M. Ultrastructural localization of antibody by antigen label with peroxidase. Exp Cell Res. 1968 Oct;53(1):166–176. doi: 10.1016/0014-4827(68)90364-9. [DOI] [PubMed] [Google Scholar]
  2. CARD W. I., MARKS I. N. The relationship between the acid output of the stomach following "maximal" histamine stimulation and the parietal cell mass. Clin Sci. 1960 Feb;19:147–163. [PubMed] [Google Scholar]
  3. Cowley D. J., Ganguli P. C., Polak J. M., Elder J. B., Pearse A. G. The G cell population of the pyloric antrum of the cat. Digestion. 1975;12(1):25–31. doi: 10.1159/000197650. [DOI] [PubMed] [Google Scholar]
  4. Delaney J. P., Michel H. M., Eisenberg M. M., Bonsack M. Quantitation of antral gastrin cell populations in the dog. Gastroenterology. 1978 Apr;74(4):708–712. [PubMed] [Google Scholar]
  5. Delince P., Willems G., de Graef J. Antral gastrin cell proliferation after vagotomy in rats. Digestion. 1978;18(1-2):27–34. doi: 10.1159/000198181. [DOI] [PubMed] [Google Scholar]
  6. Ganguli P. C., Polak J. M., Pearse A. G., Elder J. B., Hegarty M. Antral-gastrin-cell hyperplasia in peptic-ulcer disease. Lancet. 1974 Apr 6;1(7858):583–586. doi: 10.1016/s0140-6736(74)92647-6. [DOI] [PubMed] [Google Scholar]
  7. Keuppens F., Bremen J., Woussen-Colle M. C., De Graef J. Failure to pentagastrin administration to restore postprandial acid secretion from Heidenhain pouches after antrectomy in dogs. Surgery. 1976 Nov;80(5):586–590. [PubMed] [Google Scholar]
  8. Keuppens F., Willems G., Vansteenkiste Y., Woussen-Colle M. C. Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. Surg Gynecol Obstet. 1978 Mar;146(3):400–406. [PubMed] [Google Scholar]
  9. McGuigan J. E., Trudeau W. L. Serum gastrin levels before and after vagotomy and pyloroplasty or vagotomy and antrectomy. N Engl J Med. 1972 Jan 27;286(4):184–188. doi: 10.1056/NEJM197201272860404. [DOI] [PubMed] [Google Scholar]
  10. Polak J. M., Stagg B., Pearse A. G. Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut. 1972 Jul;13(7):501–512. doi: 10.1136/gut.13.7.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Royston C. M., Polak J., Bloom S. R., Cooke W. M., Russell R. C., Pearse A. G., Spencer J., Welbourn R. B., Baron J. H. G cell population of the gastric antrum, plasma gastrin, and gastric acid secretion in patients with and without duodenal ulcer. Gut. 1978 Aug;19(8):689–698. doi: 10.1136/gut.19.8.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stave R., Brandtzaeg P., Nygaard K., Fausa O. The transitional body-antrum zone in resected human stomachs. Anatomical outline and parietal-cell and gastrin-cell characteristics in peptic ulcer disease. Scand J Gastroenterol. 1978;13(6):685–691. doi: 10.3109/00365527809181782. [DOI] [PubMed] [Google Scholar]
  13. Stern D. H., Walsh J. H. Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin. Gastroenterology. 1973 Mar;64(3):363–369. [PubMed] [Google Scholar]
  14. Willems G., Nyst M., Delincé P., De Graef J. Direct method for estimating the total gastrin cell number in the stomach of rats. Gastroenterology. 1976 Sep;71(3):533–536. [PubMed] [Google Scholar]
  15. Woussen-Colle M. C., Willems G., Graef G. D. Relationship of the gastrin response to the amount of food ingested in normal subjects. Digestion. 1977;15(4):322–328. doi: 10.1159/000198018. [DOI] [PubMed] [Google Scholar]

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