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. 1975 Dec;253(2):493–504. doi: 10.1113/jphysiol.1975.sp011202

The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats.

E L Blair, E R Grund, J D Reed, D J Sanders, G Sanger, B Shaw
PMCID: PMC1348518  PMID: 1214222

Abstract

Chloralose anaesthetized cats were prepared with fundic and antral pouches. Fundic mucosal blood flow was measured by the amidopyrine technique and serum gastrin was measured by radioimmunoassay. 2. Meat extract suspension in the pyloric antrum produced a highly significant sixfold increase in arterial serum gastrin concentration (P less than 0-001). 3. The mean ratio of the fundic mucosal blood flow to acid secretory responses (deltaMBF/deltaH+ ratio) of 0-142 +/- 0-026 (25) ml./muequiv H+, is very similar to the values previously published for exogenous gastrin stimulation. 4. Splanchnic nerve stimulation, during responses to meat extract stimulation, produced significant reductions in gastric acid secretion (P less than 0-025), fundic mucosal blood flow (P less than 0-02), Arterial serum gastrin concentration (P less than 0-01) And gastrin delivered to the mucosa (P less than 0-001). 5. In the 30 min period following the end of splanchnic nerve stimulation only arterial serum gastrin concentration remained significantly reduced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CELANDER O. The range of control exercised by the sympathico-adrenal system; a quantitative study on blood vessels and other smooth muscle effectors in the cat. Acta Physiol Scand Suppl. 1954;32(116):1–132. [PubMed] [Google Scholar]
  2. CUMMING J. D., HAIGH A. L., HARRIES E. H., NUTT M. E. A STUDY OF GASTRIC SECRETION AND BLOOD FLOW IN THE ANAESTHETIZED DOG. J Physiol. 1963 Aug;168:219–233. doi: 10.1113/jphysiol.1963.sp007188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FOLKOW B., LEWIS D. H., LUNDGREN O., MELLANDER S., WALLENTIN I. THE EFFECT OF GRADED VASOCONSTRICTOR FIBRE STIMULATION ON THE INTESTINAL RESISTANCE AND CAPACITANCE VESSELS. Acta Physiol Scand. 1964 Aug;61:445–457. [PubMed] [Google Scholar]
  4. GOODFRIEND T. L., LEVINE L., FASMAN G. D. ANTIBODIES TO BRADYKININ AND ANGIOTENSIN: A USE OF CARBODIIMIDES IN IMMUNOLOGY. Science. 1964 Jun 12;144(3624):1344–1346. doi: 10.1126/science.144.3624.1344. [DOI] [PubMed] [Google Scholar]
  5. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  7. Harper A. A., Reed J. D., Smy J. R. Gastric blood flow in anaesthetized cats. J Physiol. 1968 Feb;194(3):795–807. doi: 10.1113/jphysiol.1968.sp008435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hayes J. R., Kennedy T. L., Ardill J., Shanks R. G., Buchanan K. D. Stimulation of gastrin release by catecholamines. Lancet. 1972 Apr 15;1(7755):819–821. doi: 10.1016/s0140-6736(72)90802-1. [DOI] [PubMed] [Google Scholar]
  9. Herbert V., Lau K. S., Gottlieb C. W., Bleicher S. J. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab. 1965 Oct;25(10):1375–1384. doi: 10.1210/jcem-25-10-1375. [DOI] [PubMed] [Google Scholar]
  10. Jackson B. M., Reeder D. D., Thompson J. C. Dynamic characteristics of gastrin release. Am J Surg. 1972 Feb;123(2):137–142. doi: 10.1016/0002-9610(72)90323-6. [DOI] [PubMed] [Google Scholar]
  11. Jaffe B. M., McGuigan J. E., Newton W. T. Immunochemical measurement of the vagal release of gastrin. Surgery. 1970 Jul;68(1):196–201. [PubMed] [Google Scholar]
  12. McGuigan J. E. Immunochemical studies with synthetic human gastrin. Gastroenterology. 1968 Jun;54(6):1005–1011. [PubMed] [Google Scholar]
  13. Midgley A. R. Radioimmunoassay for human follicle-stimulating hormone. J Clin Endocrinol Metab. 1967 Feb;27(2):295–299. doi: 10.1210/jcem-27-2-295. [DOI] [PubMed] [Google Scholar]
  14. Reed J. D., Sanders D. J. Pepsin secretion, gastric motility and mucosal blood flow in the anaesthetized cat. J Physiol. 1971 Jul;216(1):159–170. doi: 10.1113/jphysiol.1971.sp009515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reed J. D., Sanders D. J., Thorpe V. The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat. J Physiol. 1971 Apr;214(1):1–13. doi: 10.1113/jphysiol.1971.sp009415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reed J. D., Smy J. R. Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation. J Physiol. 1971 Dec;219(3):571–585. doi: 10.1113/jphysiol.1971.sp009678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SHAFER P. W., KITTLE C. F. The relation of the autonomic nervous system to gastric secretion with particular reference to the sympathetic nerves. Surgery. 1951 Jan;29(1):1–10. [PubMed] [Google Scholar]
  18. Stadil F., Rehfeld J. F. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol. 1973;8(2):101–112. [PubMed] [Google Scholar]
  19. Stadil F., Rehfeld J. F. Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis. Scand J Clin Lab Invest. 1972 Dec;30(4):361–368. doi: 10.3109/00365517209080271. [DOI] [PubMed] [Google Scholar]
  20. Stadil F., Rehfeld J. F. Release of gastrin by epinephrine in man. Gastroenterology. 1973 Aug;65(2):210–215. [PubMed] [Google Scholar]
  21. THOMPSON J. E., VANE J. R. Gastric secretion induced by histamine and its relationship to the rate of blood flow. J Physiol. 1953 Sep;121(3):433–444. doi: 10.1113/jphysiol.1953.sp004956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Temperley J. M., Wyllie J. H., Stagg B. H. Inactivation of gastric and pentagastrin in the portal circulation. Gut. 1970 Dec;11(12):1060–1061. [PubMed] [Google Scholar]
  23. Trudeau W. L., McGuigan J. E. Relations between serum gastrin levels and rates of gastric hydrochloric acid secretion. N Engl J Med. 1971 Feb 25;284(8):408–412. doi: 10.1056/NEJM197102252840803. [DOI] [PubMed] [Google Scholar]

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