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. 1973 Dec;235(2):535–550. doi: 10.1113/jphysiol.1973.sp010402

Activation of descending control of the spinocervical tract by impulses ascending the dorsal columns and relaying through the dorsal column nuclei

A G Brown, H F Martin III
PMCID: PMC1350761  PMID: 4357940

Abstract

1. Micro-electrode recordings were made from axons of the spinocervical tract in unanaesthetized decerebrate cats.

2. Orthodromic activation of the dorsal columns and dorsal column nuclei was used to condition responses evoked in spinocervical tract neurones from cutaneous nerves. Such conditioning produced inhibition of transmission through the tract. The inhibition had a time course of 200 msec or more with maximal action at 30-70 msec and was most effective against polysynaptic responses.

3. After removal of the cerebellum or section of the cerebellar peduncles the degree of inhibition was reduced but inhibition could still be evoked by activation of the dorsal columns and dorsal column nuclei.

4. Transection of the brain stem just rostral to the dorsal column nuclei removed the inhibitory effects although segmental inhibition was not affected.

5. It is concluded that impulses ascending the dorsal columns and relaying through the dorsal column nuclei can lead to activation of descending control of the spinocervical tract. Parts of the pathways involved include the cerebellum and the brain stem. It is unlikely that the cells in the dorsal column nuclei which have descending axons are concerned with the control of transmission through the spinocervical tract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown A. G. Effects of descending impulses on transmission through the spinocervical tract. J Physiol. 1971 Dec;219(1):103–125. doi: 10.1113/jphysiol.1971.sp009652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown A. G., Franz D. N. Responses of spinocervical tract neurones to natural stimulation of identified cutaneous receptors. Exp Brain Res. 1969;7(3):231–249. doi: 10.1007/BF00239031. [DOI] [PubMed] [Google Scholar]
  3. Brown A. G., Kirk E. J., Martin H. F., 3rd Descending and segmental inhibition of transmission through the spinocervical tract. J Physiol. 1973 May;230(3):689–705. doi: 10.1113/jphysiol.1973.sp010212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dart A. M. Cells of the dorsal column nuclei projecting down into the spinal cord. J Physiol. 1971 Dec;219(2):29P–30P. [PubMed] [Google Scholar]
  5. Fetz E. E. Pyramidal tract effects on interneurons in the cat lumbar dorsal horn. J Neurophysiol. 1968 Jan;31(1):69–80. doi: 10.1152/jn.1968.31.1.69. [DOI] [PubMed] [Google Scholar]
  6. GORDON G., JUKES M. G. DUAL ORGANIZATION OF THE EXTEROCEPTIVE COMPONENTS OF THE CAT'S GRACILE NUCLEUS. J Physiol. 1964 Sep;173:263–290. doi: 10.1113/jphysiol.1964.sp007456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GORDON G., SEED W. A. An investigation of nucleus gracilis of the cat by antidromic stimulation. J Physiol. 1961 Mar;155:589–601. doi: 10.1113/jphysiol.1961.sp006649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOLMQVIST B., OSCARSSON O., ROSEN I. Functional organization of the cuneocrebellar tract in the cat. Acta Physiol Scand. 1963 Jun-Jul;58:216–235. doi: 10.1111/j.1748-1716.1963.tb02643.x. [DOI] [PubMed] [Google Scholar]
  9. KUYPERS H. G., TUERK J. D. THE DISTRIBUTION OF THE CORTICAL FIBRES WITHIN THE NUCLEI CUNEATUS AND GRACILIS IN THE CAT. J Anat. 1964 Apr;98:143–162. [PMC free article] [PubMed] [Google Scholar]
  10. Larson B., Miller S., Oscarsson O. Termination and functional organization of the dorsolateral spino-olivocerebellar path. J Physiol. 1969 Aug;203(3):611–640. doi: 10.1113/jphysiol.1969.sp008882. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. TAUB A. LOCAL, SEGMENTAL AND SUPRASPINAL INTERACTION WITH A DORSOLATERAL SPINAL CUTANEOUS AFFERENT SYSTEM. Exp Neurol. 1964 Oct;10:357–374. doi: 10.1016/0014-4886(64)90006-8. [DOI] [PubMed] [Google Scholar]
  12. Wall P. D. The laminar organization of dorsal horn and effects of descending impulses. J Physiol. 1967 Feb;188(3):403–423. doi: 10.1113/jphysiol.1967.sp008146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wall P. D. The sensory and motor role of impulses travelling in the dorsal columns towards cerebral cortex. Brain. 1970;93(3):505–524. doi: 10.1093/brain/93.3.505. [DOI] [PubMed] [Google Scholar]

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