Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1969 May;201(3):639–655. doi: 10.1113/jphysiol.1969.sp008777

The effects of changes in haematocrit on the intrarenal distribution of blood flow in the dog's kidney

F S Nashat, F R Scholefield, J W Tappin, C S Wilcox
PMCID: PMC1351415  PMID: 5767886

Abstract

1. The effect of changes in the haematocrit of blood perfusing the kidney on its intrarenal distribution was studied in dogs.

2. Two types of preparations were employed. (i) In the isolated perfused kidney evidence is presented that flow in the autoregulating preparation represents predominantly cortical flow while flow in the `low flow non-autoregulating' kidney reflects medullary flow. (ii) In the intact kidney renal blood flow rate and its intrarenal distribution was studied by the injection of 133Xe into the renal artery and measuring its clearance from the kidney by an external counter.

3. In both types of preparation cortical flow was found to be independent of changes in P.C.V. but medullary flow varied inversely with haematocrit.

4. A change in the haematocrit of the perfusing blood leads to alteration of its viscosity. It was argued that an increase in viscosity must lead to a reduction in the resistance of the cortical afferent arterioles but that medullary afferent arterioles were not able to respond in this manner.

5. These findings demonstrate that changes in total body haematocrit cause a redistribution of blood flow between renal cortex and medulla.

Full text

PDF
641

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUKLAND K., BERLINER R. W. RENAL MEDULLARY COUNTERCURRENT SYSTEM STUDIED WITH HYDROGEN GAS. Circ Res. 1964 Nov;15:430–442. doi: 10.1161/01.res.15.5.430. [DOI] [PubMed] [Google Scholar]
  2. Aperia A. C., Liebow A. A., Roberts L. E. Renal adaptation to anemia. Circ Res. 1968 Apr;22(4):489–500. doi: 10.1161/01.res.22.4.489. [DOI] [PubMed] [Google Scholar]
  3. DE WARDENER H. E., McSWINEY R. R., MILES B. E. Renal haemodynamics in primary polycythaemia. Lancet. 1951 Aug 4;2(6675):204–205. doi: 10.1016/s0140-6736(51)91442-0. [DOI] [PubMed] [Google Scholar]
  4. Dreizen P. RHEOLOGY OF HUMAN BLOOD. STUDIES ON THE FLOW OF FRESH VENOUS BLOOD AND OF CITRATED BLOOD THROUGH TUBING OF DIAMETERS BETWEEN 0.09 AND 0.20 CM. J Clin Invest. 1962 Nov;41(11):2036–2053. doi: 10.1172/JCI104662. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. EARLEY L. E., FRIEDLER R. M. CHANGES IN RENAL BLOOD FLOW AND POSSIBLY THE INTRARENAL DISTRIBUTION OF BLOOD DURING THE NATRIURESIS ACCOMPANYING SALINE LOADING IN THE DOG. J Clin Invest. 1965 Jun;44:929–941. doi: 10.1172/JCI105210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KRAMER K. [The role of the kidney in the systemic circulation]. Verh Dtsch Ges Inn Med. 1959;65:225–241. [PubMed] [Google Scholar]
  7. Ladefoged J. Measurements of the renal blood flow in man with the 133 xenon wash-out technique. A description of the method. Scand J Clin Lab Invest. 1966;18(3):299–315. doi: 10.3109/00365516609087200. [DOI] [PubMed] [Google Scholar]
  8. Ladefoged J., Pedersen F., Doutheil U., Deetjen P., Selkurt E. E. Renal blood flow measured with Xenon-133 wash-out technique and with an electromagnetic flowmeter. Pflugers Arch Gesamte Physiol Menschen Tiere. 1965 Jun 15;284(3):195–200. doi: 10.1007/BF00362441. [DOI] [PubMed] [Google Scholar]
  9. Lawrence J. H., Loomis W. F., Tobias C. A., Turpin F. H. Preliminary observations on the narcotic effect of xenon with a review of values for solubilities of gases in water and oils. J Physiol. 1946 Dec 6;105(3):197–204. [PMC free article] [PubMed] [Google Scholar]
  10. Nashat F. S., Portal R. W. The effects of changes in haematocrit on renal function. J Physiol. 1967 Dec;193(3):513–522. doi: 10.1113/jphysiol.1967.sp008375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nashat F. S., Scholefield F. R., Tappin J. W. The effect of viscosity on blood flow in the isolated perfused kidney of the dog. J Physiol. 1967 Jul;191(2):124P–125P. [PubMed] [Google Scholar]
  12. ROWN J. J., DAVIES D. L., LEVER A. F., PARKER R. A., ROBERTSON J. I. THE ASSAY OF RENIN IN SINGLE GLOMERULI IN THE NORMAL RABBIT AND THE APPEARANCE OF THE JUXTAGLOMERULAR APPARATUS. J Physiol. 1965 Feb;176:418–428. doi: 10.1113/jphysiol.1965.sp007559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SHARE L. Primary effects of acute oligocythemia on renal function. Am J Physiol. 1952 Oct;171(1):159–163. doi: 10.1152/ajplegacy.1952.171.1.159. [DOI] [PubMed] [Google Scholar]
  14. SPENCER M. P. Renal hemodynamics in experimental polycythemia. Am J Physiol. 1951 May;165(2):399–406. doi: 10.1152/ajplegacy.1951.165.2.399. [DOI] [PubMed] [Google Scholar]
  15. Schrier R. W., McDonald K. M., Marshall R. A., Lauler D. P. Absence of natriuretic response to acute hypotonic intravascular volume expansion in dogs. Clin Sci. 1968 Feb;34(1):57–72. [PubMed] [Google Scholar]
  16. THORBURN G. D., KOPALD H. H., HERD J. A., HOLLENBERG M., O'MORCHOE C. C., BARGER A. C. INTRARENAL DISTRIBUTION OF NUTRIENT BLOOD FLOW DETERMINED WITH KRYPTON 85 IN THE UNANESTHETIZED DOG. Circ Res. 1963 Oct;13:290–307. doi: 10.1161/01.res.13.4.290. [DOI] [PubMed] [Google Scholar]
  17. THURAU K., DEETJEN P., KRAMER K. [Hemodynamics of kidney medullary substance. Part II. Interrelationships between the vascular and tubular counter-flow system in arterial pressure increases, water diuresis and osmotic diuresis]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;270:270–285. [PubMed] [Google Scholar]
  18. THURAU K., KRAMER K. Weitere Untersuchungen zur myogenen Natur der Autoregulation des Nierenkreislaufes; Aufhebung der Autoregulation durch muskulotrope Substanzen und druckpassives Verhalten des Glomerulusfiltrates. Pflugers Arch. 1959;269(1):77–93. doi: 10.1007/BF00362973. [DOI] [PubMed] [Google Scholar]
  19. THURAU K. RENAL HEMODYNAMICS. Am J Med. 1964 May;36:698–719. doi: 10.1016/0002-9343(64)90181-0. [DOI] [PubMed] [Google Scholar]
  20. VIRGILIO R. W., LONG D. M., MUNDTH E. D., MCCLENATHAN J. E. THE EFFECT OF TEMPERATURE AND HEMATOCRIT ON THE VISCOSITY OF BLOOD. Surgery. 1964 Jun;55:825–830. [PubMed] [Google Scholar]
  21. Whittaker S. R., Winton F. R. The apparent viscosity of blood flowing in the isolated hindlimb of the dog, and its variation with corpuscular concentration. J Physiol. 1933 Jul 10;78(4):339–369. doi: 10.1113/jphysiol.1933.sp003009. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES