Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1969 Sep;204(1):51–61. doi: 10.1113/jphysiol.1969.sp008897

The effects of alloxan and histamine on the permeability of the pulmonary alveolocapillary barrier to albumin

Boyd W Goetzman, Maurice B Visscher
PMCID: PMC1351592  PMID: 5352071

Abstract

1. [131I]albumin transport from alveolus to perfusion fluid was evaluated in an isolated dog lung lobe preparation perfused at constant pressure with homologous plasma. The alveoli were filled with a 1:1 mixture of Ringer—Tyrode solution and plasma.

2. For twenty-three lung lobes, an average control permeability coefficient of the alveolocapillary membrane for albumin was found to be 1·9 × 10-9 cm/sec with a range of (0·3-5·5) × 10-9 cm/sec.

3. Alloxan in concentrations of 0·22-2·50 mg/ml. perfusate was observed to increase the alveolocapillary membrane permeability to [131I]albumin with a positive correlation between dose and effect. The larger doses of alloxan increased the permeability by a factor of ten or more.

4. Glutathione (GSH), administered intravascularly 2 min before alloxan in an 8:1 molar ratio of GSH:alloxan, delayed the onset of the permeability increase due to alloxan by 40-60 min but did not influence the maximum increase in permeability.

5. Histamine administered intravascularly in concentrations from 0·02 to 0·50 μg/ml. perfusate had no significant effect on the alveolocapillary membrane permeability to [131I]albumin.

Full text

PDF
60

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AVIADO D. M., Jr, SCHMIDT C. F. Pathogenesis of pulmonary edema by alloxan. Circ Res. 1957 Mar;5(2):180–186. doi: 10.1161/01.res.5.2.180. [DOI] [PubMed] [Google Scholar]
  2. AVIADO D. M. The pharmacology of the pulmonary circulation. Pharmacol Rev. 1960 Jun;12:159–239. [PubMed] [Google Scholar]
  3. EISEMAN B., BRYANT L., WALTUCH T. METABOLISM OF VASOMOTOR AGENTS BY THE ISOLATED PERFUSED LUNG. J Thorac Cardiovasc Surg. 1964 Nov;48:798–806. [PubMed] [Google Scholar]
  4. GILBERT R. P., HINSHAW L. B., KUIDA H., VISSCHER M. B. Effects of histamine, 5 hydroxytryptamine and epinephrine on pulmonary hemodynamics with particular reference to arterial and venous segment resistances. Am J Physiol. 1958 Jul;194(1):165–170. doi: 10.1152/ajplegacy.1958.194.1.165. [DOI] [PubMed] [Google Scholar]
  5. GUYTON A. C., LINDSEY A. W. Effect of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circ Res. 1959 Jul;7(4):649–657. doi: 10.1161/01.res.7.4.649. [DOI] [PubMed] [Google Scholar]
  6. Gaddum J. H., Holtz P. The localization of the action of drugs on the pulmonary vessels of dogs and cats. J Physiol. 1933 Jan 16;77(2):139–158. doi: 10.1113/jphysiol.1933.sp002958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HADDY F. J. Effect of histamine on small and large vessel pressures in the dog foreleg. Am J Physiol. 1960 Jan;198:161–168. doi: 10.1152/ajplegacy.1960.198.1.161. [DOI] [PubMed] [Google Scholar]
  8. HADDY F. J., STEPHENS G., VISSCHER M. B. The physiology and pharmacology of lung edema. Pharmacol Rev. 1956 Sep;8(3):389–434. [PubMed] [Google Scholar]
  9. JOCELYN P. C. Glutathione metabolism in animals. Biochem Soc Symp. 1959;17:43–65. [PubMed] [Google Scholar]
  10. ROWLEY D. A. VENOUS CONSTRICTION AS THE CAUSE OF INCREASED VASCULAR PERMEABILITY PRODUCED BY 5-HYDROXYTRYPTAMINE, HISTAMINE, BRADYKININ AND 48/80 IN THE RAT. Br J Exp Pathol. 1964 Feb;45:56–67. [PMC free article] [PubMed] [Google Scholar]
  11. SOLOMON A. K. The kinetics of biological processes; special problems connected with the use of tracers. Adv Biol Med Phys. 1953;3:65–97. doi: 10.1016/b978-1-4831-9926-9.50006-9. [DOI] [PubMed] [Google Scholar]
  12. SPECTOR W. G. Substances which affect capillary permeability. Pharmacol Rev. 1958 Dec;10(4):475–505. [PubMed] [Google Scholar]
  13. Staub N. C., Nagano H., Pearce M. L. Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs. J Appl Physiol. 1967 Feb;22(2):227–240. doi: 10.1152/jappl.1967.22.2.227. [DOI] [PubMed] [Google Scholar]
  14. TAYLOR A. E., GUYTON A. C., BISHOP V. S. PERMEABILITY OF THE ALVEOLAR MEMBRANE TO SOLUTES. Circ Res. 1965 Apr;16:353–362. doi: 10.1161/01.res.16.4.353. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES