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. 1969 Sep;204(1):169–179. doi: 10.1113/jphysiol.1969.sp008906

Vascular responses of the spleen to rapid haemorrhage in the anaesthetized cat

C V Greenway, R D Stark
PMCID: PMC1351601  PMID: 4310939

Abstract

1. Splenic blood flow, splenic weight and arterial pressure were recorded in cats anaesthetized with sodium pentobarbitone. The mechanisms of the splenic contraction and vasoconstriction which followed rapid haemorrhage were investigated.

2. When splenic arterial pressure was decreased progressively by mechanical occlusion of the coeliac artery, the decrease in splenic blood flow was proportional to the decrease in pressure; splenic weight did not change.

3. After denervation of the spleen and adrenalectomy, haemorrhage resulted in a decrease in splenic flow which was similar to but slower than that in the innervated spleen; there was no splenic contraction. After splenic denervation, adrenalectomy and nephrectomy, haemorrhage caused a smaller decrease in flow but this response was still greater than that expected as a consequence of the reduced arterial pressure.

4. Infusions of small doses of angiotensin caused splenic vasoconstriction with little change in splenic weight. Larger doses reduced both flow and weight.

5. The splenic flow and weight responses to stimulation of the sympathetic nerves remained unimpaired when splenic blood flow was substantially reduced for 1-2 hr by haemorrhage.

6. It is concluded that after a rapid haemorrhage, the splenic contraction is due only to activity of the splenic nerves and the adrenal medullae. The decrease in splenic flow is due to the reduction in arterial pressure, activity of the splenic nerves and the adrenal medullae, and the actions of angiotensin and some unidentified vasoconstrictor substance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOATMAN D. L., BRODY M. J. ANALYSIS OF VASCULAR RESPONSES IN THE SPLEEN. Am J Physiol. 1964 Jul;207:155–161. doi: 10.1152/ajplegacy.1964.207.1.155. [DOI] [PubMed] [Google Scholar]
  2. Barcroft J., Harris H. A., Orahovats D., Weiss R. A contribution to the physiology of the spleen. J Physiol. 1925 Oct 31;60(5-6):443–456. doi: 10.1113/jphysiol.1925.sp002261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FOLKOW B., LANGSTON J. THE INTERRELATIONSHIP OF SOME FACTORS INFLUENCING RENAL BLOOD FLOW AUTOREGULATION. Acta Physiol Scand. 1964 May-Jun;61:165–176. doi: 10.1111/j.1748-1716.1964.tb02952.x. [DOI] [PubMed] [Google Scholar]
  4. FOLKOW B., LEWIS D. H., LUNDGREN O., MELLANDER S., WALLENTIN I. THE EFFECT OF GRADED VASOCONSTRICTOR FIBRE STIMULATION ON THE INTESTINAL RESISTANCE AND CAPACITANCE VESSELS. Acta Physiol Scand. 1964 Aug;61:445–457. [PubMed] [Google Scholar]
  5. FROHLICH E. D., GILLENWATER J. Y. Pressure-flow relationships in the perfused dog spleen. Am J Physiol. 1963 Apr;204:645–648. doi: 10.1152/ajplegacy.1963.204.4.645. [DOI] [PubMed] [Google Scholar]
  6. Greenway C. V., Lawson A. E., Mellander S. The effects of stimulation of the hepatic nerves, infusions of noradrenaline and occlusion of the carotid arteries on liver blood flow in the anaesthetized cat. J Physiol. 1967 Sep;192(1):21–41. doi: 10.1113/jphysiol.1967.sp008285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Greenway C. V., Lawson A. E., Stark R. D. Vascular responses of the spleen to nerve stimulation during normal and reduced blood flow. J Physiol. 1968 Feb;194(2):421–433. doi: 10.1113/jphysiol.1968.sp008416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Groom A. C., Rowlands S., Thomas H. W. Some circulatory responses to haemorrhage in the cat: a critical level of blood volume for the onset of hypotension. Q J Exp Physiol Cogn Med Sci. 1965 Oct;50(4):385–405. doi: 10.1113/expphysiol.1965.sp001805. [DOI] [PubMed] [Google Scholar]
  9. Hodge R. L., Lowe R. D., Vane J. R. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. J Physiol. 1966 Aug;185(3):613–626. doi: 10.1113/jphysiol.1966.sp008005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LUNDGREN O., LUNDWALL J., MELLANDER S. RANGE OF SYMPATHETIC DISCHARGE AND REFLEX VASCULAR ADJUSTMENTS IN SKELETAL MUSCLE DURING HEMORRHAGIC HYPOTENSION. Acta Physiol Scand. 1964 Dec;62:380–390. doi: 10.1111/j.1748-1716.1964.tb10436.x. [DOI] [PubMed] [Google Scholar]
  11. MELLANDER S., LEWIS D. H. EFFECT OF HEMORRHAGIC SHOCK ON THE REACTIVITY OF RESISTANCE AND CAPACITANCE VESSELS AND ON CAPILLARY FILTRATION TRANSFER IN CAT SKELETAL MUSCLE. Circ Res. 1963 Aug;13:105–118. doi: 10.1161/01.res.13.2.105. [DOI] [PubMed] [Google Scholar]
  12. Pinardi G. Effects of denervation on the hemodynamics of the spleen during irreversible shock. Acta Physiol Lat Am. 1968;18(3):248–252. [PubMed] [Google Scholar]
  13. ROTHE C. F., SCHWENDENMANN F. C., SELKURT E. E. Neurogenic control of skeletal muscle vascular resistance in hemorrhagic shock. Am J Physiol. 1963 May;204:925–932. doi: 10.1152/ajplegacy.1963.204.5.925. [DOI] [PubMed] [Google Scholar]
  14. Regoli D., Vane J. R. The continuous estimation of angiotensin formed in the circulation of the dog. J Physiol. 1966 Apr;183(3):513–531. doi: 10.1113/jphysiol.1966.sp007881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. ZETTERSTROM B. E., PALMERIO C., FINE J. PROTECTION OF FUNCTIONAL AND VASCULAR INTEGRITY OF THE SPLEEN IN TRAUMATIC SHOCK BY DENERVATION. Proc Soc Exp Biol Med. 1964 Nov;117:373–376. doi: 10.3181/00379727-117-29584. [DOI] [PubMed] [Google Scholar]

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