Abstract
1. Using a sensitive method for detecting and monitoring sweat secretion, a study has been made of the effects of adrenaline and noradrenaline on the cat's pad sweat gland activity in the anaesthetized cat.
2. Intravenous or intra-arterial injections of adrenaline or noradrenaline only very occasionally caused these glands to secrete.
3. The predominant effect of these drugs on glands which are already secreting in response to plantar nerve stimulation is inhibitory.
4. The catecholamine inhibition could be reduced or blocked by phentolamine, but not by propranolol, dibenamine or phenoxybenzamine.
5. It is concluded that these glands can be directly activated by intravascular injections of adrenaline or noradrenaline, but that the inhibitory effect of concomitant vasoconstriction usually prevents a response being detected at the skin surface.
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Selected References
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- BLACK J. W., CROWTHER A. F., SHANKS R. G., SMITH L. H., DORNHORST A. C. A NEW ADRENERGIC BETARECEPTOR ANTAGONIST. Lancet. 1964 May 16;1(7342):1080–1081. doi: 10.1016/s0140-6736(64)91275-9. [DOI] [PubMed] [Google Scholar]
- Burn J. H. The secretion of sweat and vaso-dilatation produced by pilocarpine. J Physiol. 1925 Oct 31;60(5-6):365–378. doi: 10.1113/jphysiol.1925.sp002255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COLLINS K. J., SARGENT F., WEINER J. S. Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-beta-methylcholine and adrenaline. J Physiol. 1959 Oct;148:592–614. doi: 10.1113/jphysiol.1959.sp006309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FELLOWS E. J., McLEAN R. A., MACKO E., KERWIN J. F., HALL G. C., MILNES F. J., WITT I. H., ULLYOT G. E. Oral and intravenous adrenolytic activity of a number of N-benzyl-N-phenoxyethyl and N-benzyl-N-Phenoxyisopropyl-2-chlorethylamines. J Pharmacol Exp Ther. 1954 Apr;110(4):463–469. [PubMed] [Google Scholar]
- Foster K. G. Composition of the secretion from the eccrine sweat glands of the cat's foot pad. J Physiol. 1966 May;184(1):106–119. doi: 10.1113/jphysiol.1966.sp007905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LLOYD D. P. Response of cholinergically innervated sweat glands to adrenaline and noradrenaline. Nature. 1959 Jul 25;184(Suppl 5):277–278. doi: 10.1038/184277a0. [DOI] [PubMed] [Google Scholar]
- Langley J. N. The secretion of sweat: Part I. Supposed inhibitory nerve fibres on the posterior nerve roots. Secretion after denervation. J Physiol. 1922 Feb 14;56(1-2):110–119. doi: 10.1113/jphysiol.1922.sp001995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Langley J. N., Uyeno K. The secretion of sweat: Part II. The effect of vaso-constriction and of adrenaline. J Physiol. 1922 May 16;56(3-4):206–226. doi: 10.1113/jphysiol.1922.sp002003. [DOI] [PMC free article] [PubMed] [Google Scholar]