Abstract
1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2·5% body weight of water by mouth.
2. Infusion of 300 ml. of saline (0·73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow.
3. Infusion of 100 ml. of saline (0·73g NaCl/100 ml.) to sodium-depleted dogs restores their ability to respond to a water-load of 2·5% of body weight by diuresis.
4. The results are discussed and a tentative explanation put forward.
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Selected References
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