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. 1966 Jan;182(1):150–163. doi: 10.1113/jphysiol.1966.sp007815

Transfer of propionate by rat small intestine in vitro

R J C Barry, M J Jackson, D H Smyth
PMCID: PMC1357462  PMID: 5937409

Abstract

1. The transfer of propionate by sacs of rat everted intestine has been investigated in relation to a number of physico-chemical factors which affect movement of weak electrolytes.

2. Neither the observed movement nor the distribution of propionate can be accounted for by the theory of non-ionic diffusion or by modifications of it, such as the microclimate hypothesis or partial permeability to ions.

3. It is not possible to account for the observed propionate movement by the electrical potential across the gut or by solvent drag.

4. The most satisfactory explanation for the observations is a transfer process in the gut for volatile fatty acids, and some features of this are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRY B. A., MATTHEWS J., SMYTH D. H. Transfer of glucose and fluid by different parts of the small intestine of the rat. J Physiol. 1961 Jul;157:279–288. doi: 10.1113/jphysiol.1961.sp006721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRY R. J., DIKSTEIN S., MATTHEWS J., SMYTH D. H., WRIGHT E. M. ELECTRICAL POTENTIALS ASSOCIATED WITH INTESTINAL SUGAR TRANSFER. J Physiol. 1964 Jun;171:316–338. doi: 10.1113/jphysiol.1964.sp007379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BARRY R. J., SMYTH D. H. Transfer of short-chain fatty acids by the intestine. J Physiol. 1960 Jun;152:48–66. doi: 10.1113/jphysiol.1960.sp006468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FISHER R. B. The absorption of water and of some non-electrolytes from the surviving small intestine of the rat. J Physiol. 1954 May 28;124(2):21–2P. [PubMed] [Google Scholar]
  5. HAKIM A. A., LIFSON N. UREA TRANSPORT ACROSS DOG INTESTINAL MUCOSA IN VITRO. Am J Physiol. 1964 Jun;206:1315–1320. doi: 10.1152/ajplegacy.1964.206.6.1315. [DOI] [PubMed] [Google Scholar]
  6. HOGBEN C. A., TOCCO D. J., BRODIE B. B., SCHANKER L. S. On the mechanism of intestinal absorption of drugs. J Pharmacol Exp Ther. 1959 Apr;125(4):275–282. [PubMed] [Google Scholar]
  7. HOGBEN C. A. The alimentary tract. Annu Rev Physiol. 1960;22:381–406. doi: 10.1146/annurev.ph.22.030160.002121. [DOI] [PubMed] [Google Scholar]
  8. NEWEY H., SANFORD P. A., SMYTH D. H. URANYL IONS AND INTESTINAL HEXOSE TRANSFER. Nature. 1965 Jan 23;205:389–390. doi: 10.1038/205389a0. [DOI] [PubMed] [Google Scholar]
  9. NEWEY H., SMYTH D. H. Cellular mechanisms in intestinal transfer of amino acids. J Physiol. 1962 Dec;164:527–551. doi: 10.1113/jphysiol.1962.sp007035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. NEWEY H., SMYTH D. H. EFFECTS OF SUGARS ON INTESTINAL TRANSFER OF AMINO-ACIDS. Nature. 1964 Apr 25;202:400–401. doi: 10.1038/202400b0. [DOI] [PubMed] [Google Scholar]
  11. PARSONS B. J., SMYTH D. H., TAYLOR C. B. The action of phlorrhizin on the intestinal transfer of glucose and water in vitro. J Physiol. 1958 Dec 30;144(3):387–402. doi: 10.1113/jphysiol.1958.sp006109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCHANKER L. S. Passage of drugs across body membranes. Pharmacol Rev. 1962 Dec;14:501–530. [PubMed] [Google Scholar]
  13. SHORE P. A., BRODIE B. B., HOGBEN C. A. The gastric secretion of drugs: a pH partition hypothesis. J Pharmacol Exp Ther. 1957 Mar;119(3):361–369. [PubMed] [Google Scholar]
  14. SMYTH D. H., TAYLOR C. B. Intestinal transfer of short-chain fatty acids in vitro. J Physiol. 1958 Apr 3;141(1):73–80. doi: 10.1113/jphysiol.1958.sp005955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SMYTH D. H., TAYLOR C. B. Transport of water and other substances through the intestinal wall. J Physiol. 1954 Nov 29;126(2):42P–42P. [PubMed] [Google Scholar]
  16. WILSON T. H. Concentration gradients of lactate, hydrogen and some other ions across the intestine in vitro. Biochem J. 1954 Mar;56(3):521–527. doi: 10.1042/bj0560521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WILSON T. H., WISEMAN G. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J Physiol. 1954 Jan;123(1):116–125. doi: 10.1113/jphysiol.1954.sp005036. [DOI] [PMC free article] [PubMed] [Google Scholar]

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