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. 1991 Mar;213(3):227–229. doi: 10.1097/00000658-199103000-00008

Human liver regeneration after major hepatectomy. A study of liver volume by computed tomography.

M F Chen 1, T L Hwang 1, C F Hung 1
PMCID: PMC1358332  PMID: 1998403

Abstract

Regeneration of the remnant liver after major hepatectomy in humans was studied by computed axial tomography (CT) in 12 noncirrhotic and five cirrhotic patients. Liver volumes were measured by abdominal CT 3 days, 10 days, 3 months, 6 months, 1 year, and 1.5 years after resection. Of the 17 patients, liver remnant volume was increased in 21.2% +/- 6.7% and 30.6% +/- 12.7% at 3 months and 6 months after resection, respectively. Noncirrhotic livers were 28.4% +/- 9.5% and 48.4% +/- 17.8% larger at 3 and 6 months. For cirrhotic livers, the increase was 8.5% +/- 3.6% and 12.9% +/- 4.5%. In five patients with right hepatectomy (65% resection), the liver remnant volumes were increased 38.4% +/- 11.7%, 48.0% +/- 16.2% and 95.1% +/- 4.5% at 3 months, 6 months, and 1 year after resection, respectively. In seven patients with right partial hepatectomy (30% to 35% resection), the percentages were 7.4% +/- 3.2%, 21.8% +/- 8.4%, and 63.9% +/- 18.3% and in five patients with left lateral segmentectomy (15% resection), they were 15.6% +/- 8.2%, 27.8% +/- 12.2%, and 33.0% +/- 14.5% 3 months, 6 months, and 1 year after resections, respectively. Noncirrhotic livers showed better regeneration than cirrhotic livers. Complete regeneration took about 1 year. The noncirrhotic liver that underwent right lobectomy also needed 1 year to double its postresection volume.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bucher N. L. Experimental aspects of hepatic regeneration. N Engl J Med. 1967 Sep 28;277(13):686–contd. doi: 10.1056/NEJM196709282771306. [DOI] [PubMed] [Google Scholar]
  2. Chen M. F., Hwang T. L., Jeng L. B., Jan Y. Y., Wang C. S., Chou F. F. Hepatic resection in 120 patients with hepatocellular carcinoma. Arch Surg. 1989 Sep;124(9):1025–1028. doi: 10.1001/archsurg.1989.01410090031006. [DOI] [PubMed] [Google Scholar]
  3. Fisher B., Szuch P., Fisher E. R. Evaluation of a humoral factor in liver regeneration utilizing liver transplants. Cancer Res. 1971 Mar;31(3):322–331. [PubMed] [Google Scholar]
  4. Heymsfield S. B., Fulenwider T., Nordlinger B., Barlow R., Sones P., Kutner M. Accurate measurement of liver, kidney, and spleen volume and mass by computerized axial tomography. Ann Intern Med. 1979 Feb;90(2):185–187. doi: 10.7326/0003-4819-90-2-185. [DOI] [PubMed] [Google Scholar]
  5. Lee S., Broelsch C. E., Flamant Y. M., Chandler J. G., Charters A. C., 3rd, Orloff M. J. Liver regeneration after portacaval transportation in rats. Surgery. 1975 Jan;77(1):144–149. [PubMed] [Google Scholar]
  6. Lee S., Edgington T. S., Orloff M. J. The role of afferent blood supply in regeneration of liver isografts in rats. Surg Forum. 1968;19:360–362. [PubMed] [Google Scholar]
  7. Lee S., Keiter J. E., Rosen H., Williams R., Chandler J. G., Orloff M. J. Influence of blood supply on regeneration of liver transplants. Surg Forum. 1969;20:369–371. [PubMed] [Google Scholar]
  8. Lin T. Y., Lee C. S., Chen C. C., Liau K. Y., Lin W. S. Regeneration of human liver after hepatic lobectomy studied by repeated liver scanning and repeated needle biopsy. Ann Surg. 1979 Jul;190(1):48–53. doi: 10.1097/00000658-197907000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Moolten F. L., Bucher N. L. Regeneration of rat liver: transfer of humoral agent by cross circulation. Science. 1967 Oct 13;158(3798):272–274. doi: 10.1126/science.158.3798.272. [DOI] [PubMed] [Google Scholar]
  10. PACK G. T., ISLAMI A. H., HUBBARD J. C., BRASFIELD R. D. Regeneration of human liver after major hepatectomy. Surgery. 1962 Oct;52:617–623. [PubMed] [Google Scholar]
  11. Sgro J. C., Charters C., Chandler J. G., Grambort D. E., Orloff M. J. Site of origin of the hepatotrophic portal blood factor involved in liver regeneration. Surg Forum. 1973;24:377–379. [PubMed] [Google Scholar]
  12. Starzl T. E., Putnam C. W., Groth C. G., Corman J. L., Taubman J. Alopecia, ascites, and incomplete regeneration after 85 to 90 per cent liver resection. Am J Surg. 1975 May;129(5):587–590. doi: 10.1016/0002-9610(75)90323-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stone H. H., Long W. D., Smith R. B., 3rd, Haynes C. D. Physiologic considerations in major hepatic resections. Am J Surg. 1969 Jan;117(1):78–84. doi: 10.1016/0002-9610(69)90288-8. [DOI] [PubMed] [Google Scholar]

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