Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1960 May;151(2):312–331. doi: 10.1113/jphysiol.1960.sp006440

The acute effect of hydrocortisone, deoxycorticosterone and aldosterone upon the excretion of sodium, potassium and acid by the human kidney

J N Mills, S Thomas, K S Williamson
PMCID: PMC1363240  PMID: 14422655

Full text

PDF
315

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTTER F. C. The role of aldosterone in normal homeostasis and in certain disease states. Metabolism. 1956 Jul;5(4):369–383. [PubMed] [Google Scholar]
  2. BERLINER R. W., KENNEDY T. J., Jr, HILTON J. G. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1;162(2):348–367. doi: 10.1152/ajplegacy.1950.162.2.348. [DOI] [PubMed] [Google Scholar]
  3. BERLINER R. W., KENNEDY T. J., Jr, ORLOFF J. Relationship between acidification of the urine and potassium metabolism; effect of carbonic anhydrase inhibition on potassium excretion. Am J Med. 1951 Sep;11(3):274–282. doi: 10.1016/0002-9343(51)90165-9. [DOI] [PubMed] [Google Scholar]
  4. BERLINER R. W. Renal excretion of water, sodium, chloride, potassium, calcium and magnesium. Am J Med. 1950 Oct;9(4):541–559. doi: 10.1016/0002-9343(50)90205-1. [DOI] [PubMed] [Google Scholar]
  5. BLACK D. A., MILLS J. N. Nocturnal electrolyte excretion after oral administration of sodium and potassium chloride and bicarbonate. Clin Sci. 1954 May;13(2):211–219. [PubMed] [Google Scholar]
  6. COOPER G., JEFFERIES W. M., KELLY L. W., Jr, LEVY R. P., SYDNOR K. L. Metabolic effects of a single intravenous infusion of hydrocortisone related to plasma levels in a normal versus an adrenally insufficient subject. J Clin Endocrinol Metab. 1957 Feb;17(2):186–200. doi: 10.1210/jcem-17-2-186. [DOI] [PubMed] [Google Scholar]
  7. DINGMAN J. F., FINKENSTAEDT J. T., LAIDLAW J. C., RENOLD A. E., JENKINS D., MERRILL J. P., THORN G. W. Influence of intravenously administered adrenal steroids on sodium and water excretion in normal and Addisonian subjects. Metabolism. 1958 Sep;7(5):608–623. [PubMed] [Google Scholar]
  8. FOURMAN P., BARTTER F. C., ALBRIGHT F., DEMPSEY E., CARROLL E., ALEXANDER J. Effects of 17-hydroxycorticosterone ("compound F") in man. J Clin Invest. 1950 Nov;29(11):1462–1473. doi: 10.1172/JCI102386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FOURMAN P., REIFENSTEIN E. C., Jr, KEPLER E. J., DEMPSEY E., BARTTER F., ALBRIGHT F. Effect of desoxycorticosterone acetate on electrolyte metabolism in a normal man. Metabolism. 1952 May;1(3):242–253. [PubMed] [Google Scholar]
  10. FRAWLEY T. F. The role of the adrenal cortex in glucose and pyruvic acid metabolism in man including the use of intravenous hydrocortisone in acute hypoglycemia. Ann N Y Acad Sci. 1955 May 27;61(2):464–493. doi: 10.1111/j.1749-6632.1955.tb42498.x. [DOI] [PubMed] [Google Scholar]
  11. GREEN D. M., JOHNSON A. D., BRIDGES W. E., LEHMANN J. H., GRAY F. Mechanisms of desoxycorticosterone action: effects of the water-soluble glycoside on human circulatory and renal functions. Endocrinology. 1950 Aug;47(2):102–107. doi: 10.1210/endo-47-2-102. [DOI] [PubMed] [Google Scholar]
  12. HANLEY T., JOWETT G. H., KILPATRICK R., PLATTS M. M. The role of carbonic anhydrase in renal reabsorption of bicarbonate. J Physiol. 1959 Mar 3;145(2):277–288. doi: 10.1113/jphysiol.1959.sp006142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HUFFMAN E. R., WILSON G. M., Jr, CLARK G. M., SMYTH C. J. The acute renal effects of 9-alpha fluorohydrocortisone in human subjects with intact adrenals. J Lab Clin Med. 1956 May;47(5):747–751. [PubMed] [Google Scholar]
  14. KAGAWA C. M., CELLA J. A., VAN ARMAN C. G. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science. 1957 Nov 15;126(3281):1015–1016. doi: 10.1126/science.126.3281.1015. [DOI] [PubMed] [Google Scholar]
  15. KNIGHT R. P., Jr, KORNFELD D. S., GLASER G. H., BONDY P. K. Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176–181. doi: 10.1210/jcem-15-2-176. [DOI] [PubMed] [Google Scholar]
  16. LIDDLE G. W. Aldosterone antagonists. AMA Arch Intern Med. 1958 Dec;102(6):998–1004. doi: 10.1001/archinte.1958.00260230144018. [DOI] [PubMed] [Google Scholar]
  17. LIDDLE G. W. Sodium diuresis induced by steroidal antagonists of aldosterone. Science. 1957 Nov 15;126(3281):1016–1018. doi: 10.1126/science.126.3281.1016. [DOI] [PubMed] [Google Scholar]
  18. LONGSON D., MILLS J. N., THOMAS S., YATES P. A. Handling of phosphate by the human kidney at high plasma concentrations. J Physiol. 1956 Mar 28;131(3):555–571. doi: 10.1113/jphysiol.1956.sp005482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. LONGSON D., MILLS J. N. The failure of the kidney to respond to respiratory acidosis. J Physiol. 1953 Oct;122(1):81–92. doi: 10.1113/jphysiol.1953.sp004980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MILLS J. N., THOMAS S. The acute effect of adrenal hormones and carbohydrate metabolism upon plasma phosphate and potassium concentrations in man. J Endocrinol. 1957 Dec;16(2):164–179. doi: 10.1677/joe.0.0160164. [DOI] [PubMed] [Google Scholar]
  21. MILLS J. N., THOMAS S. The acute effects of cortisone and cortisol upon renal function in man. J Endocrinol. 1958 May;17(1):41–53. doi: 10.1677/joe.0.0170041. [DOI] [PubMed] [Google Scholar]
  22. MILLS J. N., THOMAS S. The influence of adrenal corticoids on phosphate and glucose exchange in muscle and liver in man. J Physiol. 1959 Oct;148:227–239. doi: 10.1113/jphysiol.1959.sp006284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. PERLMUTT J. H., OLEWINE D. A. Alteration of renal response to carbonic anhydrase inhibitor by synthetic adrenal steroids. Am J Physiol. 1958 Oct;195(1):142–146. doi: 10.1152/ajplegacy.1958.195.1.142. [DOI] [PubMed] [Google Scholar]
  24. RAISZ L. G., MCNEELY W. F., SAXON L., ROSENBAUM J. D. The effects of cortisone and hydrocortisone on water diuresis and renal function in man. J Clin Invest. 1957 Jun;36(6 Pt 1):767–779. doi: 10.1172/JCI103481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. ROSS E. J., BETHUNE J. E. Antagonism between the effect of aldosterone and a synthetic steroid lactone on the renal excretion of sodium and potassium in man. Lancet. 1959 Jan 17;1(7064):127–129. doi: 10.1016/s0140-6736(59)90006-6. [DOI] [PubMed] [Google Scholar]
  26. Schiess W. A., Ayer J. L., Lotspeich W. D., Pitts R. F., Miner P. THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. II. FACTORS AFFECTING THE EXCRETION OF TITRATABLE ACID BY THE NORMAL HUMAN SUBJECT. J Clin Invest. 1948 Jan;27(1):57–64. doi: 10.1172/JCI101924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. THORN G. W., SHEPPARD R. H., MORSE W. I., REDDY W. J., BEIGELMAN P. M., RENOLD A. E. Comparative action of aldosterone and 9-alpha-fluorohydrocortisone in man. Ann N Y Acad Sci. 1955 May 27;61(2):609–619. doi: 10.1111/j.1749-6632.1955.tb42514.x. [DOI] [PubMed] [Google Scholar]
  28. VANDER A. J., MALVIN R. L., WILDE W. S., McMURRAY V. M., LAPIDES J., SULLIVAN L. P. Effects of adrenalectomy and aldosterone on proximal and distal tubular sodium reabsorption. Proc Soc Exp Biol Med. 1958 Nov;99(2):323–325. doi: 10.3181/00379727-99-24338. [DOI] [PubMed] [Google Scholar]
  29. WIGGINS R. A., HUTCHIN M. E., CARBONE J. V., DOOLAN P. D. Effect of spirolactone SC 8109 on renal function in normal human subjects. Proc Soc Exp Biol Med. 1959 Mar;100(3):625–627. doi: 10.3181/00379727-100-24721. [DOI] [PubMed] [Google Scholar]
  30. WRONG O., DAVIES H. E. The excretion of acid in renal disease. Q J Med. 1959 Apr;28(110):259–313. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES