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. 1997 Nov;92(3):317–320. doi: 10.1046/j.1365-2567.1997.00361.x

Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes.

E Aceituno 1, S Castañón 1, C Jiménez 1, D Subirá 1, M De Górgolas 1, M Fernández-Guerrero 1, F Ortíz 1, R García 1
PMCID: PMC1363790  PMID: 9486102

Abstract

Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus-1-positive (HIV-1+) patients (CIC-HIV+), composed of anti-HIV-HIV-Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)-activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4+ lymphocytes as demonstrated by double binding of CIC-HIV+ and anti-CD4 on apoptosis cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC-HIV+ apoptosis inducers belong mainly to asymptomatic HIV-infected patients, indicating that immune complexes from these patients can destroy CD4+ lymphocytes.

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Selected References

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