Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1968 Sep;198(1):81–90. doi: 10.1113/jphysiol.1968.sp008594

A study of the end-plate potential in sodium-deficient solution

M Kordaš
PMCID: PMC1365310  PMID: 5677033

Abstract

1. The effect of anticholinesterases in lengthening the end-plate potential is much more pronounced in a low-sodium solution than in an ordinary Ringer-curare solution.

2. To investigate this difference, intracellular recordings of end-plate potentials and of end-plate currents in voltage-clamped muscle fibres were used.

3. It was found that the very large lengthening of the end-plate potential in a low-sodium solution was due to a combination of three factors: (i) lengthening of the underlying end-plate current, (ii) an increased membrane resistance and (iii) marked inward-going (anomalous) rectification of the muscle membrane.

Full text

PDF
81

Images in this article

83Fig. 1
on p.83
84Fig. 2
on p.84
85Fig. 3
on p.85

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian R. H., Freygang W. H. The potassium and chloride conductance of frog muscle membrane. J Physiol. 1962 Aug;163(1):61–103. doi: 10.1113/jphysiol.1962.sp006959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beránek R., Vyskocil F. The effect of atropine on the frog sartorius neuromuscular junction. J Physiol. 1968 Mar;195(2):493–503. doi: 10.1113/jphysiol.1968.sp008470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boyle P. J., Conway E. J. Potassium accumulation in muscle and associated changes. J Physiol. 1941 Aug 11;100(1):1–63. doi: 10.1113/jphysiol.1941.sp003922. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown G. L., Dale H. H., Feldberg W. Reactions of the normal mammalian muscle to acetylcholine and to eserine. J Physiol. 1936 Sep 8;87(4):394–424. doi: 10.1113/jphysiol.1936.sp003414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DEL CASTILLO J., KATZ B. Local activity at a depolarized nerve-muscle junction. J Physiol. 1955 May 27;128(2):396–411. doi: 10.1113/jphysiol.1955.sp005315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DEL CASTILLO J., KATZ B. Quantal components of the end-plate potential. J Physiol. 1954 Jun 28;124(3):560–573. doi: 10.1113/jphysiol.1954.sp005129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DEL CASTILLO J., KATZ B. Statistical factors involved in neuromuscular facilitation and depression. J Physiol. 1954 Jun 28;124(3):574–585. doi: 10.1113/jphysiol.1954.sp005130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FATT P., KATZ B. An analysis of the end-plate potential recorded with an intracellular electrode. J Physiol. 1951 Nov 28;115(3):320–370. doi: 10.1113/jphysiol.1951.sp004675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FURUKAWA T., SASAOKA T., HOSOYA Y. Effects of tetrodotoxin on the neuromuscular junction. Jpn J Physiol. 1959 Jun 25;9(2):143–152. doi: 10.2170/jjphysiol.9.143. [DOI] [PubMed] [Google Scholar]
  10. HODGKIN A. L., HOROWICZ P. The effect of sudden changes in ionic concentrations on the membrane potential of single muscle fibres. J Physiol. 1960 Sep;153:370–385. doi: 10.1113/jphysiol.1960.sp006540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HODGKIN A. L., HOROWICZ P. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J Physiol. 1959 Oct;148:127–160. doi: 10.1113/jphysiol.1959.sp006278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HUTTER O. F., NOBLE D. The chloride conductance of frog skeletal muscle. J Physiol. 1960 Apr;151:89–102. [PMC free article] [PubMed] [Google Scholar]
  13. HUTTER O. F., PADSHA S. M. Effect of nitrate and other anions on the membrane resistance of frog skeletal muscle. J Physiol. 1959 Apr 23;146(1):117–132. doi: 10.1113/jphysiol.1959.sp006182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HUTTER O. F. Post-tetanic restoration of neuromuscular transmission blocked by D-tubocurarine. J Physiol. 1952 Oct;118(2):216–227. doi: 10.1113/jphysiol.1952.sp004788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KATZ B., MILEDI R. PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS. Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:453–482. doi: 10.1098/rspb.1965.0015. [DOI] [PubMed] [Google Scholar]
  16. KATZ B., MILEDI R. THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS. Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496–503. doi: 10.1098/rspb.1965.0017. [DOI] [PubMed] [Google Scholar]
  17. KELLY J. S. ANTAGONISM BETWEEN NA+ AND CA2+ AT THE NEUROMUSCULAR JUNCTION. Nature. 1965 Jan 16;205:296–297. doi: 10.1038/205296a0. [DOI] [PubMed] [Google Scholar]
  18. Katz B., Miledi R. Tetrodotoxin and neuromuscular transmission. Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8–22. doi: 10.1098/rspb.1967.0010. [DOI] [PubMed] [Google Scholar]
  19. MILEDI R. Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres. J Physiol. 1960 Apr;151:24–30. [PMC free article] [PubMed] [Google Scholar]
  20. NARAHASHI T., DEGUCHI T., URAKAWA N., OHKUBO Y. Stabilization and rectification of muscle fiber membrane by tetrodotoxin. Am J Physiol. 1960 May;198:934–938. doi: 10.1152/ajplegacy.1960.198.5.934. [DOI] [PubMed] [Google Scholar]
  21. Rahamimoff R., Colomo F. Inhibitory action of sodium ions on transmitter release at the motor end-plate. Nature. 1967 Sep 9;215(5106):1174–1176. doi: 10.1038/2151174a0. [DOI] [PubMed] [Google Scholar]
  22. TAKEUCHI A., TAKEUCHI N. Active phase of frog's end-plate potential. J Neurophysiol. 1959 Jul;22(4):395–411. doi: 10.1152/jn.1959.22.4.395. [DOI] [PubMed] [Google Scholar]
  23. TAKEUCHI N. Some properties of conductance changes at the end-plate membrane during the action of acetylcholine. J Physiol. 1963 Jun;167:128–140. doi: 10.1113/jphysiol.1963.sp007136. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES