Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1967 Jul;191(1):167–176. doi: 10.1113/jphysiol.1967.sp008243

Further studies of the metabolism of thyroxine and 3,5,3′-triiodothyronine in the guinea-pig

K Brown-Grant
PMCID: PMC1365445  PMID: 6050612

Abstract

1. Thyroxine labelled with 125I and triiodothyronine labelled with 131I have been administered simultaneously to guinea-pigs and their metabolism studied by whole body counting and measurement of radioactivity in urine, faeces, and blood.

2. The half-life of triiodothyronine in the body is about 19 hr, significantly less than that of thyroxine (41 hr).

3. After triiodothyronine administration, an unidentified iodinated compound appears in the blood which complicates the estimation of the half-life of this hormone by measurement of the radioactivity in peripheral blood.

4. A previous report, based on measurements of blood radioactivity, that the half-lives of the two hormones are similar in the guinea-pig was not confirmed.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN-GRANT K. THYROID HORMONE METABOLISM IN GUINEA-PIGS, MICE AND RATS. J Physiol. 1963 Oct;168:599–612. doi: 10.1113/jphysiol.1963.sp007210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BROWN-GRANT K. Variation in throid gland activity during the oestrous cycle in guinea-pigs. J Endocrinol. 1962 Dec;25:405–406. doi: 10.1677/joe.0.0250405. [DOI] [PubMed] [Google Scholar]
  3. FARER L. S., ROBBINS J., BLUMBERG B. S., RALL J. E. Thyroxine-serum protein complexes in various animals. Endocrinology. 1962 May;70:686–696. doi: 10.1210/endo-70-5-686. [DOI] [PubMed] [Google Scholar]
  4. FORD D. H., COREY K. R., GROSS J. The localization of thyroid hormones in the organs and tissues of the guinea pig: an autoradiographic and chromatographic study. Endocrinology. 1957 Oct;61(4):426–447. doi: 10.1210/endo-61-4-426. [DOI] [PubMed] [Google Scholar]
  5. RAY A. K., PREMACHANDRA B. M. PERIPHERAL METABOLISM OF THYROXINE AND TRIIODOTHYRONINE IN THE GUINEA PIG. Endocrinology. 1964 May;74:800–802. doi: 10.1210/endo-74-5-800. [DOI] [PubMed] [Google Scholar]
  6. TATA J. R. The effect of self- and external radiations on 131I-labelled L-thyroxine and 3,5,3'-triiodo-L-thyronine in solution. Clin Chim Acta. 1959 May;4(3):427–437. doi: 10.1016/0009-8981(59)90115-9. [DOI] [PubMed] [Google Scholar]
  7. TATA J. R. The partial purification and properties of thyroxine dehalogenase. Biochem J. 1960 Nov;77:214–226. doi: 10.1042/bj0770214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. TATA J. R. Transiodination of proteins during enzymic de-iodination of thyroxine. Nature. 1960 Sep 17;187:1025–1026. doi: 10.1038/1871025a0. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES