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. 1967 Jul;191(1):167–176. doi: 10.1113/jphysiol.1967.sp008243

Further studies of the metabolism of thyroxine and 3,5,3′-triiodothyronine in the guinea-pig

K Brown-Grant
PMCID: PMC1365445  PMID: 6050612

Abstract

1. Thyroxine labelled with 125I and triiodothyronine labelled with 131I have been administered simultaneously to guinea-pigs and their metabolism studied by whole body counting and measurement of radioactivity in urine, faeces, and blood.

2. The half-life of triiodothyronine in the body is about 19 hr, significantly less than that of thyroxine (41 hr).

3. After triiodothyronine administration, an unidentified iodinated compound appears in the blood which complicates the estimation of the half-life of this hormone by measurement of the radioactivity in peripheral blood.

4. A previous report, based on measurements of blood radioactivity, that the half-lives of the two hormones are similar in the guinea-pig was not confirmed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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