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. 1961 May;1(5):389–400. doi: 10.1016/s0006-3495(61)86897-5

Damage by Visible Light to the Acridine Orange-DNA Complex

David Freifelder, Peter F Davison, E Peter Geiduschek
PMCID: PMC1366317  PMID: 13701685

Abstract

Salmon DNA has been irradiated with visible light in the presence of acridine orange. If the dye is bound to the DNA, there results: (a) a decrease in sedimentation coefficient, (b) a lowering of viscosity, and (c) a decrease in the thermal denaturation temperature. CsCl banding experiments show that the first two effects reflect depolymerization of the DNA. Depolymerization apparently occurs by single-strand scission although some double-strand scission is not excluded. The destabilization of secondary structure results probably from chemical attack on the components of the individual strands.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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