Skip to main content
PMC home page
Biophysical Journal logoLink to Biophysical Journal
. 1969 Jul;9(7):970–990. doi: 10.1016/S0006-3495(69)86431-3

A Structural Analysis of Nerve Myelin

C R Worthington, A E Blaurock
PMCID: PMC1367492  PMID: 5797381

Abstract

A structure analysis of the low-angle X-ray diffraction data from nerve myelin is described. The low-angle X-ray data are interpreted in terms of an electron density strip model which has five parameters, these refer to the dimensions of the membrane pair and their component electron densities. Three sets of low-angle X-ray data from peripheral nerve swollen in media of different electron densities are analyzed and membrane pair dimensions and component electron densities on an absolute scale are assigned. Membrane pair dimensions are given for a variety of peripheral nerve myelins and central nervous system myelins.

Full text

PDF
971

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEN GEREN B. The formation from the Schwann cell surface of myelin in the peripheral nerves of chick embryos. Exp Cell Res. 1954 Nov;7(2):558–562. doi: 10.1016/s0014-4827(54)80098-x. [DOI] [PubMed] [Google Scholar]
  2. Blaurock A. E., Worthington C. R. Low-angle x-ray diffraction patterns from a variety of myelinated nerves. Biochim Biophys Acta. 1969 Apr;173(3):419–426. doi: 10.1016/0005-2736(69)90006-6. [DOI] [PubMed] [Google Scholar]
  3. Blaurock A. E., Worthington C. R. Treatment of low angle x-ray data from planar and concentric multilayered structures. Biophys J. 1966 May;6(3):305–312. doi: 10.1016/S0006-3495(66)86658-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FINEAN J. B., BURGE R. E. THE DETERMINATION OF THE FOURIER TRANSFORM OF THE MYELIN LAYER FROM A STUDY OF SWELLING PHENOMENA. J Mol Biol. 1963 Dec;7:672–682. doi: 10.1016/s0022-2836(63)80115-1. [DOI] [PubMed] [Google Scholar]
  5. FINEAN J. B., MILLINGTON P. F. Effects of ionic strength of immersion medium on the structure of peripheral nerve myelin. J Biophys Biochem Cytol. 1957 Jan 25;3(1):89–94. doi: 10.1083/jcb.3.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FINEAN J. B. Phospholipid-cholesterol complex in the structure of myelin. Experientia. 1953 Jan 15;9(1):17–19. doi: 10.1007/BF02147697. [DOI] [PubMed] [Google Scholar]
  7. MOODY M. F. X-RAY DIFFRACTION PATTERN OF NERVE MYELIN: A METHOD FOR DETERMINING THE PHASES. Science. 1963 Nov 29;142(3596):1173–1174. doi: 10.1126/science.142.3596.1173. [DOI] [PubMed] [Google Scholar]
  8. Worthington C. R., Blaurock A. E. A low-angle x-ray diffraction study of the swelling behavior of peripheral nerve myelin. Biochim Biophys Acta. 1969 Apr;173(3):427–435. doi: 10.1016/0005-2736(69)90007-8. [DOI] [PubMed] [Google Scholar]
  9. Worthington C. R., Blaurock A. E. Electron density model for nerve myelin. Nature. 1968 Apr 6;218(5136):87–88. doi: 10.1038/218087a0. [DOI] [PubMed] [Google Scholar]
  10. Worthington C. R. The interpretation of low-angle X-ray data from planar and concentric multilayered structures. The use of one-dimensional electron density strip models. Biophys J. 1969 Feb;9(2):222–234. doi: 10.1016/S0006-3495(69)86381-2. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES