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. 1970 Jun;10(6):519–538. doi: 10.1016/S0006-3495(70)86317-2

Studies on Ion Distribution in Living Cells

II. Cooperative Interaction between Intracellular Potassium and Sodium Ions

Gilbert N Ling, Grace Bohr
PMCID: PMC1367795  PMID: 5452352

Abstract

New steady levels of K+ and Na+ ion in frog sartorius muscle were reached in 72 hr at 25°C in environments containing 100-mM Na+-ion and K+-ion concentrations varying from near zero to 10 mM. These steady levels follow a pattern predicted by a cooperative adsorption isotherm presented in 1964. From a total of 13 sets of experiments carried out over a five year period, the average concentration of adsorption sites is 109 μmoles/g of fresh cells. The average intrinsic equilibrium constant for the Na → K exchange is 135, and the average free energy of nearest neighbor interaction is 0.54 kcal/mole. These values are in good agreement with those obtained by Jones and Karreman from studies on canine carotid arteries.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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