Abstract
A method of analyzing permeability or diffusion temperature-flux data, for the case of two parallel, independent diffusion fluxes is presented. Separate activation energies and frequency factors corresponding to independent and concurrent Arrhenius mechanisms are obtained from this procedure when the fluxes are of comparable magnitude. The method is developed in terms of membrane permeability theory since spatially separate and distinct diffusion pathways are of frequent occurrence in biological membranes. It is illustrated in the specific case of water diffusion through a keratin membrane. The results implicate the presence of “bound” water as a crucial factor in passive diffusion of water and polar molecules through the membrane.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- DAVSON H. Growth of the concept of the paucimolecular membrane. Circulation. 1962 Nov;26:1022–1037. doi: 10.1161/01.cir.26.5.1022. [DOI] [PubMed] [Google Scholar]
- HAYS R. M., LEAF A. The state of water in the isolated toad bladder in the presence and absence of vasopressin. J Gen Physiol. 1962 May;45:933–948. doi: 10.1085/jgp.45.5.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KEDEM O., KATCHALSKY A. A physical interpretation of the phenomenological coefficients of membrane permeability. J Gen Physiol. 1961 Sep;45:143–179. doi: 10.1085/jgp.45.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Patlak C. S., Goldstein D. A., Hoffman J. F. The flow of solute and solvent across a two-membrane system. J Theor Biol. 1963 Nov;5(3):426–442. doi: 10.1016/0022-5193(63)90088-2. [DOI] [PubMed] [Google Scholar]